Anti-Müllerian hormone concentration in sheep and its dependence of age and independence of BMP15 genotype: An endocrine predictor to select the best donors for embryo biotechnologies

Crespo, Belén Lahoz; Alabart, J. L.; Cocero, M.J.; Monniaux, Danielle; Echegoyen, E.; Sánchez, Pilar Fernández; Folch, J.

doi:10.1016/j.theriogenology.2013.09.033

Cited by 51 publications

(47 citation statements)

References 36 publications

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“…Likewise, it has been shown that is a marked increase in AMH between 1 and 3 months of age in cattle also (Monniaux et al 2013). In prepubertal Rasa aragonesa ewe lambs the maximum plasma AMH concentration has been seen at different ages (3, 4.5, or 6 months of age) in different ewe lambs (Lahoz et al 2014). This finding may suggest the possibility of an increase in AMH concentrations later in life in the animals from the low AFC group.…”

Section: Discussionmentioning

confidence: 85%

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Torres-Rovira¹,

Succu²,

Pasciu³

et al. 2016

Reproduction

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The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage of the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days of age, we designed this study to determine whether differences found in ovarian status during the early prepubertal period are due to different patterns of postnatal pituitary activation, and to assess whether these differences have long lasting effects on subsequent reproductive performance. Results showed that ewe lambs with high antral follicle count (AFC) at 50 days of age had significantly lower plasma FSH concentrations and higher anti-Mullerian hormone (AMH) concentrations during the first 9 weeks of age compared with low AFC ewe lambs (P!0.0001). With a longitudinal experiment we showed that a high AFC in the early prepubertal period is associated with consistently higher AMH concentrations and numbers of antral follicles up to the postpubertal period, and with higher pregnancy rates in the first breeding season. In addition, the effect of age in decreasing AMH concentrations was more marked in the low AFC group. Results of the present study demonstrate that ewe lambs undergo different patterns of postnatal pituitary activation. A high AFC at 50 days of age indicates an advanced phase of ovarian maturation, which was accompanied by constantly higher AMH concentrations up to the postpubertal period, a greater ovarian response to FSH stimulation and by higher pregnancy rates at first mating, as compared with the low AFC group.

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Section: Discussionmentioning

confidence: 85%

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Torres-Rovira¹,

Succu²,

Pasciu³

et al. 2016

Reproduction

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“…In contrast to cattle, the limited number of studies conducted in sheep indicate that AMH concentrations before puberty are not correlated with AMH in adulthood (Lahoz et al 2014) but are positively associated with fertility at first mating. In this and other farm species, the potential association between AMH and reproductive performance remains largely unexplored.…”

Section: Discussionmentioning

confidence: 89%

“…In addition, AMH reached its peak at different times among animals, and prepubertal AMH was not correlated to AMH concentrations in adulthood (Lahoz et al 2014). In Sarda ewe lambs (bred for milk production), AMH was not detectable in individuals with a low AFC; and, in those with a high AFC, AMH concentrations increased from 2 to 5 weeks and declined from 6 weeks of age (Torres-Rovira et al 2016).…”

Section: Alterations In Circulating Amh Concentrations From Birth To mentioning

confidence: 90%

“…In prepubertal Rasa Aragonesa lambs (mainly bred for meat and wool production), AMH concentrations tended to increase from 3 to 4.5 months and to decline at 6 months of age, but the within-animal repeatability was low (Lahoz et al 2014). In addition, AMH reached its peak at different times among animals, and prepubertal AMH was not correlated to AMH concentrations in adulthood (Lahoz et al 2014).…”

Section: Alterations In Circulating Amh Concentrations From Birth To mentioning

confidence: 96%

“…In addition, AMH concentrations before treatment were predictive of the response to superovulation in sheep (Lahoz et al 2014), goats (Monniaux et al 2011) and mares (Claes & Ball 2016). These findings confirm the positive association between the response to superovulation and the ovarian reserve and support the use of AMH assessment to select donors for embryo production.…”

Section: Superovulationmentioning

confidence: 99%

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Anti-Müllerian Hormone (AMH) and fertility management in agricultural species

Mossa¹,

Jimenez-Krassel²,

Scheetz³

et al. 2017

Reproduction

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A reliable, easy to assess marker for fertility in agricultural species would be highly desirable and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes recent findings concerning AMH and its role in fertility management, mainly in cattle. It focuses on (1) alterations in circulating AMH concentrations from birth to puberty and during estrous cycles; (2) correlation of circulating AMH concentrations with ovarian follicle numbers and ovarian reserve; (3) factors that impact circulating AMH concentrations; (4) use of AMH as a predictor of fertility. Circulating AMH concentrations can be easily and reliably measured with a single blood sample in adult cattle because AMH varies minimally during the estrous cycle and is repeatable across multiple cycles. Circulating AMH concentrations are positively associated with several measures of fertility. Dairy heifers with low compared with higher AMH concentrations subsequently had lower pregnancy rates, higher probability of being culled after birth of their first calf and shorter herd longevity. Also, AMH is predictive of response to superovulation in cattle and sheep. Several factors contribute to the variability in AMH concentrations among individuals; for example, beef cattle have higher AMH than dairy cattle. Nutritional imbalances, disease and endocrine disruptors during fetal life may negatively program the size of the ovarian reserve and consequently serum AMH concentrations and potential fertility in adulthood. We conclude that AMH may be a predictor of fertility and herd longevity in cattle, whereas in sheep and other farm species, the potential association between AMH and reproductive performance remains largely unexplored. Free Italian abstract: An Italian translation of this abstract is freely available at http://www.reproduction-online.org/content/154/1/ R1/suppl/DC1. Reproduction (2017) 154 R1-R11

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ET-Technologien bei kleinen Wiederkäuern

Ledda,

Gonzalez-Bulnes

2023

Biotechnologie Bei Nutztieren 1

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Anti-Müllerian hormone concentration in sheep and its dependence of age and independence of BMP15 genotype: An endocrine predictor to select the best donors for embryo biotechnologies

Cited by 51 publications

References 36 publications

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Anti-Müllerian Hormone (AMH) and fertility management in agricultural species

ET-Technologien bei kleinen Wiederkäuern

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