Anti-Müllerian hormone-based prediction model for a live birth in assisted reproduction

Marca, Antonio La; Nelson, Scott M.; Sighinolfi, Giovanna; Manno, Massimo; Baraldi, Enrica; Roli, L.; Xella, Susanna; Marsella, Tiziana; Tagliasacchi, Daniela; D’Amico, Roberto; Volpe, Annibale

doi:10.1016/j.rbmo.2010.11.005

Cited by 133 publications

(102 citation statements)

References 45 publications

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“…The two markers are strongly related to the quantitative aspect of ovarian reserve; hence a low AMH and/or AFC are highly indicative of possible low number of growing follicles and oocyte following ovarian stimulation. Moreover, both low AMH and AFC have been associated to reduced pregnancy and live birth following IVF independent of age [35][36][37][38][39][40][41]. This may indicate some relationship between quantity and quality of oocytes, with a The present study because of its retrospective design has relevant limitations, including a biased selection of women recruited for the study.…”

Section: Discussionmentioning

confidence: 86%

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Marca

Grisendi

Giulini

et al. 2015

J Assist Reprod Genet

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Purpose to compare the baseline characteristics and chance of live birth in the different categories of poor responders identified by the combinations of the Bologna criteria and establish whether these groups comprise a homogenous population. Methods database containing clinical and laboratory information on IVF treatment cycles carried out at the Mother-Infant Department of the University Hospital of Modena between year 2007 and 2011 was analysed. This data was collected prospectively and recorded in the registered database of the fertility centre. Eight hundred and thirty women fulfilled the inclusion/ exclusion criteria of the study and 210 women fulfilled the Bologna criteria definition for poor ovarian response (POR). Five categories of poor responders were identified by different combinations of the Bologna criteria. Results There were no significant differences in female age, AFC, AMH, cycle cancellation rate and number of retrieved oocytes between the five groups. The live birth rate ranged between 5.5 and 7.4 % and was not statistically different in the five different categories of women defined as poor responders according to the Bologna criteria. Conclusion The study demonstrates that the different groups of poor responders based on the Bologna criteria have similar IVF outcomes. This information validates the Bologna criteria definition as women having a uniform poor prognosis and also demonstrates that the Bologna criteria poor responders in the various subgroups represent a homogenous population with similar pre-clinical and clinical outcomes.

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Section: Discussionmentioning

confidence: 86%

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Marca

Grisendi

Giulini

et al. 2015

J Assist Reprod Genet

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“…The introduction of AMH in reproductive endocrinology can be considered a revolution in the prediction of the ovarian reserve and response , resulting in the individualization of treatment strategies and counseling of couples regarding the likelihood of the success of IVF treatment [10,11]. There is a trend toward using AMH to individualize treatment strategies and optimize the overall efficacy of IVF treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In their study, the rate of decline in mean AMH values was 0.2 ng/ml/year through age 40, with AMH values diminishing to 0.1 ng/ml/year thereafter. In a longitudinal observational study, de Vet et al [11] investigated whether serum concentrations of AMH had the potential to be used as a marker for ovarian aging. In the interval between two visits, which ranged from 1.1 to 7.3 years (mean, 2.6 ± 1.7 years), the concentrations of AMH decreased significantly over time (median value, 2.1 g/l at visit 1 vs. 1.3 g/l at visit 2), whereas the number of antral follicles and levels of FSH and inhibin B did not change.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Distribution of Basal Anti-Mullerian Hormone Levels in a Population of Infertile Women

Özcan¹,

Fıçıcıoğlu²,

Yeşiladalı³

et al. 2016

Ann Clin Anal Med

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ÖzetAmaç: Mevcut araştırmada kadınlarda serum Anti-Müllerian Hormon (AMH) ölçümlerinin yaşa özgü referans değerlerini belirlemek, yaşa özgü beklenen değerlerle ilgili bir referans değeri oluşturmak ve çocuk sahibi olmak amacıy-la infertilite polikliniğine başvuran doğurgan yaştaki Türk kadınlarının bazal serum AMH seviyelerinin dağılımını analiz etmeyi amaçladık. Gereç ve Yön-tem: Türkiye' deki tek bir infertilite merkezine 12 aylık period içinde başvuran 409 kadının siklusun 2-3. gününde prospektif olarak toplanan AMH ölçümleri-nin retrospektif analizi yapılmıştır. Bulgular: Serum AMH konsantrasyonu yaş-la birlikte azalma göstermiştir. Yaş ortalaması 34.04±5.39, serum AMH konsantrasyon ortalaması 1.77±1.82 idi. AMH seviyeleri 20-24, 25-29, 30-34, 35-39, ve >40 yaş gruplarına göre incelendi. Ortanca AMH değerleri belirtilen yaşlara göre sırası ile 2.16 ng/ml, 2.15 ng/ml, 1.71 ng/ml, 0.80 ng/ml ve 0.47 ng/ml'dir. Tartışma: Çalışmada sunulan mevcut veriler Türk infertile kadınlar-da serum AMH konsantrasyonu için bir çerçeve oluşturacaktır. Anahtar KelimelerAnti-Müllerian Hormon; Reprodüktif Yaş; Yaşa Özgü Değerler Concentrations of serum AMH were shown to decrease with advancing age of the female partner. The mean age of the women was 34.04±5.39 years and the mean AMH level of the women was 1.77±1.82. The AMH levels were grouped according to age as follows: 20-24, 25-29, 30-34,35-39, and >40 years. The median AMH values were 2.16 ng/ml, 2.15 ng/ml, 1.71 ng/ml, 0.80 ng/ml, and 0.47 ng/ml, respectively according to the age groups. Discussion:The present data provide a framework for age-specific serum AMH levels in a Turkish population of infertile women.

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“…Other studies in more selected IVF populations reported that the greater the proportion of women with diminished ovarian response, the greater the utility of screening them with serum AMH [11,14,25,26]. Because maternal age remains the strongest prognostic factor in IVF, the models based on age and serum AMH appear to be more informative than each marker alone [15,19]. The cutoffs identified in this study for serum AMH should not be extrapolated to other settings.…”

Section: Discussionmentioning

confidence: 76%

“…However, the practical utility of this marker to predict pregnancy is currently uncertain, and probably limited by the lack of association of AMH with embryo quality [12]. Only recently, studies have evaluated the ability of day 3 AMH to predict the likelihood of a live birth, and the balanced conclusion would be that the women at the extremes of basal AMH have different live birth rates (8); however, no single AMH cutoff has achieved a satisfactory combination of sensitivity, specificity, and predictive power for this outcome [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Serum antimüllerian hormone measurements with second generation assay at two distinct menstrual cycle phases for prediction of cycle cancellation, pregnancy and live birth after in vitro fertilization

Rezende

Rocha

Cruz

et al. 2014

J Assist Reprod Genet

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Purpose This study investigated the usefulness of serum antimüllerian hormone (AMH) measurements at two distinct menstrual cycle phases to predict in vitro fertilization (IVF) outcomes. Methods This was a prospective observational study enrolling 135 consecutive patients referred for conventional IVF or ICSI in a university hospital. Blood samples were obtained for serum AMH measurements on days 3 and 18-20, while transvaginal ultrasound was performed for antral follicle count (AFC) at day 3 of the menstrual cycle immediately before treatment. AMH was measured with the new Beckman Coulter Generation II (GenII) assay. The main outcome measures were cycle cancellation due to poor ovarian response, clinical pregnancy, and live birth. Results There was a strong correlation between AMH levels measured at day 3 and day 18-20 of the menstrual cycle (r= 0.837; P<0.0001). Day 18-20 serum AMH was comparable to day 3 serum AMH and AFC for the prediction of cycle cancellation (areas under the ROC curve were 0.84 for day 3 AMH, 0.89 for day 18-20 AMH, and 0.80 for AFC). Day 18-20 AMH had a modest predictive value for pregnancy or live birth (area under ROC curve 0.71 for both), which was comparable to that of day 3 AMH; however, AFC had no predictive value for these outcomes. Conclusions Day 18-20 AMH was comparable to day 3 AMH for the prediction of cycle cancellation, clinical pregnancy, and live birth after IVF. Both AMH measurements were accurate for the prediction of cancellation but were significantly less useful for the prediction of pregnancy or live birth.

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Anti-Müllerian hormone-based prediction model for a live birth in assisted reproduction

Cited by 133 publications

References 45 publications

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Age-Related Distribution of Basal Anti-Mullerian Hormone Levels in a Population of Infertile Women

Serum antimüllerian hormone measurements with second generation assay at two distinct menstrual cycle phases for prediction of cycle cancellation, pregnancy and live birth after in vitro fertilization

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