Anti-Mullerian-Hormone – an indicator for the severity of polycystic ovarian syndrome?

Köninger, Angela; Schmidt, B; Koch, Lisa Langdon; Edimiris, Philippos; Enekwe, A; Kasimir‐Bauer, Sabine; Strowitzki, Thomas

doi:10.1055/s-0034-1388008

Cited by 9 publications

(19 citation statements)

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“…Next to sonographic parameters and androgens, which were used in the streaming of PCOS patients, patients with severe PCOS also showed higher levels of AMH and LH and higher LH/FSH ratios than did patients with mild PCOS and controls. AMH appears one of the single best and useful parameters to determine different degrees of PCOS at the group level [12,13,18,19]. Similar results were found in our study: the AMH levels of the PCOS group was higher than those of the control group; this was statistically significant (p < 0.001).…”

Section: Discussionsupporting

confidence: 89%

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The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome

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Akduman

et al. 2017

The European Research Journal

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Objectives. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting up to 10% of reproductive-age women. Anti-Mullerian hormone (AMH) is a member of the transforming growth factor β family and has an inhibitory effect on primordial follicle recruitment in the ovary. The study aimed to investigate the importance of serum AMH levels in the different phenotypes of PCOS and find the optimal cut-off level of AMH in PCOS patients. Methods. This was a prospective clinical trial in which diagnoses of 50 PCOS patients based on Rotterdam revised criteria were compared to 50 normo-ovulatory cases. Additionally, the PCOS group was divided into 2 subgroups based on 2 or 3 Rotterdam criteria and compared to 50 normo-ovulatory cases. Results. When compared with the control group, the AMH levels of the PCOS group were significantly higher than those of the control group (6.81 ± 2.8 ng/ml vs. 3.22 ± 2.2 ng/ml, p < 0.001). In the subgroup analysis, the AMH levels of Group 1 and Group 2 were significantly higher than those of the control group (p < 0.001). The AMH cut-off value of 4.1 ng/ml was found to distinguish healthy women from PCOS patients, with 84% sensitivity and 80% specificity. Conclusions. Subgroup analyses showed higher levels of AMH in the severe PCOS group, but the difference was not statistically significant. More studies are suggested for researching the different PCOS subgroups to detect optimal AMH thresholds.

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Section: Discussionsupporting

confidence: 89%

“…Additionally, AMH shows different PCOS phenotypes of varied severity [12,13,17,18]. Koninger et al [19] compared the diagnostic potency of AMH with sonographic views of ovaries, ovarian volume, testosterone, androstenedione, luteinizing hormone (LH), and the LH/FSH ratio for the purpose of establishing the age-dependency of AMH.…”

Section: Introductionmentioning

confidence: 99%

The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome

Okçu

Nazık

Akduman

et al. 2017

The European Research Journal

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show abstract

“…In addition, AMH is an objective, easily doable, noninvasive test, sensitive and specific in diagnosis of PCOS and gives an estimate of the ovarian reserve. [24][25][26][27][28][29][30][31][32][33] The limitations of our study are in its retrospective nature and small sample size. Future prospectively designed studies with larger populations in persistent acne patients will help in assessing the use of AMH as a tool to diagnose PCOS in acne population.…”

Section: Discussionmentioning

confidence: 93%

“…4.23.24 AMH is a simple blood test to confirm PCOS and has been studied extensively in nondermatological literature. 4,[24][25][26][27][28][29][30][31][32] Serum AMH levels are significantly higher in women with PCOS as compared to women with normal ovaries and 27 correlate with antral follicle count, ovarian volume, and severity of PCOS. Importantly, it is not affected by the adiposity, time of the cycle and has consistent age-dependent values.…”

Section: Discussionmentioning

confidence: 99%

“…26,31 Eilertsen et al 31 concluded that AMH could successfully replace PCOM for the diagnosis of PCOS and that substitution of AMH with PCOM was equally effective for diagnosis in both the AES (Androgen Excess Society) and Rotterdam criteria an opinion that was supported by Sahmay S et al 26 Thus, in the hormonal workup of persistent acne in females, AMH may be used as a parameter to diagnose PCOM and is superior to testing for androgens and gonadotropins (K€ oninger A et al). 32 Associations between plasma AMH levels and other hormonal parameters in women with PCOS have been reported. 27 In the present study, we found a positive correlation between AMH and LH levels, in agreement with a previous study.…”

Section: Discussionmentioning

confidence: 99%

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