Anti-Mullerian Hormone: an indicator for the severity of polycystic ovarian syndrome

Köninger, Angela; Koch, Lisa Langdon; Edimiris, Philippos; Enekwe, A; Nagarajah, James; Kasimir‐Bauer, Sabine; Strowitzki, T.; Schmidt, B

doi:10.1007/s00404-014-3317-2

Cited by 40 publications

(24 citation statements)

References 25 publications

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“…The association of AMH level with HA observed in our study was consistent with the finding of previous studies that AMH level was positively correlated with symptom severity in PCOS [19,20]. AMH concentration was previously shown to be positively correlated with testosterone level in normogonadotropic anovulatory infertile women [21].…”

Section: Discussionsupporting

confidence: 93%

Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value

Song

Lee

et al. 2017

Korean J Intern Med

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Background/AimsAlthough increased serum anti-Müllerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic value has not been determined. We aimed to observe the relationship between the AMH level and PCOS phenotypes and to determine the optimal cutoff value of AMH for the diagnosis of PCOS in young Korean women.MethodsWe recruited 207 women with PCOS (120 with PCOM and 87 without PCOM) and 220 regular cycling women with normoandrogenemia (100 with PCOM and 120 without PCOM). Subjects underwent testing at a single outpatient visit. Serum AMH level was measured.ResultsWomen with PCOS had higher serum AMH levels than did regular cycling women with normoandrogenemia (p < 0.05). Women with PCOM had higher serum AMH levels than women without PCOM, regardless of PCOS status (p < 0.05). The optimal AMH cutoff value for the diagnosis of PCOS was 10.0 ng/mL (71% sensitivity, 93% specificity). Serum AMH was an independent determinant of total testosterone after adjustment for age, body mass index, and the number of menses/year (β = 0.31, p < 0.01). An association between AMH and hyperandrogenism was only observed in women with PCOS, and it was independent of the presence of PCOM.ConclusionThe serum AMH level can be useful for the diagnosis of PCOS at any age less than 40 years, and the optimal cutoff value for the diagnosis of PCOS identified in this study of young Korean women was 10.0 ng/mL.

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Section: Discussionsupporting

confidence: 93%

Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value

Song

Lee

et al. 2017

Korean J Intern Med

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“…It may also have the potential to screen for polycystic ovarian syndrome as women with this condition are likely to have higher follicle counts, which is well correlated with AMH levels as our study has shown. [17] Our study strongly supports the addition of AMH assessment to evaluate woman before making decisions pertaining to infertility intervention.…”

Section: Discussionsupporting

confidence: 69%

Assessment of ovarian reserve: Anti-Mullerian hormone versus follicle stimulating hormone

et al. 2016

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Background:This study aimed to evaluate the strength of anti-Mullerian hormone (AMH) and follicle stimulating hormone (FSH) in reflecting the antral follicle count (AFC) in infertile females.Materials and Methods:This cross-sectional study was conducted on 160 females, visiting infertility clinic for assisted reproduction. Serum samples collected on the 3rd day of the cycle were assayed for FSH, luteinizing hormone, and AMH while AFC was assessed via transvaginal ultrasound. The study cohort was segregated into three groups based on AFC.Results:Chronological age and FSH was significantly high in females with very low AFC (P < 0.01 and 0.009, respectively), yet they failed to discriminate patients with normal and higher follicle count (P = 0.65 and 0.84). Conversely, AMH reported highly significant difference between very low AFC and with those having either normal AFC (P = 0.002) or higher AFC (P = 0.001). Moreover, a significant difference in AMH was observed between normal and higher AFC group (P = 0.04).Conclusion:Compared to female’s age and FSH, AMH is superior in clustering study cohort on the bases of antral follicular pool, especially in setups with nonavailability of technological expertise to assess AFC. Incorporation of AMH along with other biomarkers improves estimation of baseline ovarian reserve, required to standardize dose for optimum response; avoiding the risk of failure to retrieve oocyte or inappropriate stimulation leading to ovarian hyperstimulation syndrome. Further prospective studies are required to ascertain its role in predicting the outcomes of ART in such patients.

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“…Thus, there is a need for a blood test that reliably correlates with PCOM/PCOS, which is the antimullerian hormone (AMH). 4.23.24 AMH is a simple blood test to confirm PCOS and has been studied extensively in nondermatological literature . Serum AMH levels are significantly higher in women with PCOS as compared to women with normal ovaries and correlate with antral follicle count, ovarian volume, and severity of PCOS.…”

Section: Discussionmentioning

confidence: 99%

The role of antimullerian hormone in the hormonal workup of women with persistent acne

Sardana

Singh

Narang

et al. 2016

J of Cosmetic Dermatology

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Anti-Mullerian Hormone: an indicator for the severity of polycystic ovarian syndrome

Cited by 40 publications

References 25 publications

Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value

Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value

Assessment of ovarian reserve: Anti-Mullerian hormone versus follicle stimulating hormone

The role of antimullerian hormone in the hormonal workup of women with persistent acne

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