Anti muellerian hormone serum levels in women with endometriosis: A case–control study

Shebl, Omar; Ebner, Thomas; Sommergruber, Michael; Sir, Andreas; Tews, G

doi:10.3109/09513590903159615

Cited by 71 publications

(31 citation statements)

References 20 publications

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“…The mean serum AMH level of the 141 patients with endometrioma (group 2) was significantly lower compared to the 1,323 patients without endometrioma (control group) (Figures 1, 2, Table 2). Shebl et al reported that AMH levels were significantly lower in patients with severe endometriosis than in the control group [22]. In agreement with Shebl's reports, we also found that patients with ovarian endometriomas had significantly lower serum AMH levels compared with patients without endometriomas.…”

Section: Discussionsupporting

confidence: 92%

The impact of endometrioma and laparoscopic cystectomy on serum anti-Müllerian hormone levels

Hwu

et al. 2011

Reprod Biol Endocrinol

113

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BackgroundSerum anti-Müllerian hormone (AMH) had been proposed as a marker of ovarian reserve. The aim of this study was to evaluate the impact of endometrioma and laparoscopic cystectomy on ovarian reserve as measured by serum AMH levels.MethodsA total of 1,642 patients were recruited in this retrospective analysis. Control group (group 1) included 1,323 infertility patients without endometrioma. Endometrioma group (group 2) included 141 patients with ovarian endometrioma. Previous cystectomy group (group 3) included 147 patients who underwent unilateral or bilateral laparoscopic cystectomy due to ovarian endometrioma more than 6 months before enrollment. Current cystectomy group (group 4) included 31 patients who underwent cystectomy during study period. Serum anti-müllerian hormone (AMH) levels were measured upon enrollment with all patients. For patients in group 4, AMH levels were measured before and 3 months after cystectomy.ResultsMean AMH level of patients in control group was significantly higher than that of endometrioma group or previous cystectomy group in each age subgroup, while the mean serum AMH level of the endometrioma group was also significantly higher than that of the previous cystectomy group in each age subgroup. The mean AMH level was significantly lower in patients with previous bilateral cystectomy compared to that of patients with unilateral cystectomy. The mean serum AMH level was also significantly lower in patients with bilateral endometrioma compared to that of patients with unilateral endometrioma. In group 4, mean AMH level significantly decreased from 3.95 +/- 0.42 preoperation to 2.01 +/- 0.21 ng/ml at 3-month postoperation.ConclusionsBoth ovarian endometrioma and cystectomy are associated with a significant reduction on ovarian reserve. Bilateral endometrioma exerts a more profound negative impact on ovarian reserve than unilateral endometrioma, regardless of either conservative or surgical intervention.

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Section: Discussionsupporting

confidence: 92%

The impact of endometrioma and laparoscopic cystectomy on serum anti-Müllerian hormone levels

Hwu

et al. 2011

Reprod Biol Endocrinol

113

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“…Nevertheless, contradictory results also exist 26,27. The majority of previous studies regarding AMH value in endometriosis patients have focused on infertile patients participating in IVF 8,28. However, to explain the risk of reduced fecundity in endometriosis patients, ovarian reserve should be evaluated among the general population, regardless of existence of infertility.…”

Section: Discussionmentioning

confidence: 99%

“…Previous study noted that infertile patients with endometriosis exhibit decreased serum anti-mullerian hormone (AMH) levels compared to male factor infertility, and advocated that measuring AMH may be beneficial in optimizing the dose needed for gonadotropin treatment prior to ovarian stimulation 8. Moreover, further research suggested similarities in ovarian reserve in infertility patients with minimal/mild endometriosis compared to patients with tubal obstruction 9.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Serum Anti-Mullerian Hormone Level in Women with Ovarian Endometrioma and Mature Cystic Teratoma

et al. 2013

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PurposeTo investigate whether preoperative serum anti-mullerian hormone (AMH) levels are lower in women with ovarian endometrioma and in women with mature cystic teratoma of the ovaries.Materials and MethodsIn a tertiary university hospital, a retrospective case-control study was performed. Serum AMH levels between an advanced (stage III and IV) endometrioma group (n=102) and an age- and body mass index (BMI)-matched control group were compared. Serum AMH levels between an ovarian mature cystic teratoma group (n=48) and age- and BMI-matched controls were also compared.ResultsAbsolute serum AMH and multiples of the median for AMH (AMH-MoM) relevant to Korean standards were lower in the endometrioma group than controls, but this was not statistically significant (mean±SEM, 2.9±0.3 ng/mL vs. 3.3±0.3 ng/mL, p=0.28 and 1.3±0.1 vs. 1.6±0.1, p=0.29, respectively). Specifically, the stage IV endometriosis group (n=51) exhibited significantly lower serum AMH and AMH-MoM (2.1±0.3 vs. 3.1±0.4 ng/mL, p=0.02 and 1.1±0.1 vs. 1.7±0.2, p=0.03, respectively). Serum AMH and AMH-MoM levels were similar between stage III endometriosis and controls (3.7±0.5 vs. 3.4±0.5 ng/mL and 1.6±0.2 vs. 1.5±0.2, respectively), as well as between the mature cystic teratoma group and controls (4.0±0.5 ng/mL vs. 4.0±0.5 ng/mL and 1.6±0.2 vs. 1.6±0.3, respectively). Interestingly, AMH-MoM level was negatively correlated with endometriosis score with statistical significance (r2=0.13, p<0.01).ConclusionIn women with advanced ovarian endometrioma, preoperative serum AMH values tended to be lower than those for age and BMI-matched controls. Notably, stage IV endometrioma appeared to be closely associated with decreased ovarian reserve, even before operation. Clinicians should keep this information in mind before undertaking surgery of ovarian endometrioma.

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“…Recently, it was demonstrated that infertile patients with minimal and mild endometriosis had lower serum MIS levels compared to a cohort of infertility patients with tubal occlusion but no endometriosis [29]. However, serum MIS levels do not show a significant fluctuation during a spontaneous menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

Mullerian Inhibiting Substance Suppresses Proliferation and Induces Apoptosis and Autophagy in Endometriosis Cells In Vitro

Borahay

Lü

Özpolat

et al. 2013

ISRN Obstetrics and Gynecology

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Objective. To determine the effects of Mullerian inhibiting substance (MIS) treatment on endometriosis cells through study of apoptosis and autophagy. Design. Experimental in vitro study. Setting. University research laboratory. Cell Line. CRL-7566 endometriosis cell line. This line was established from a benign ovarian cyst taken from a patient with endometriosis. Interventions. In vitro treatment with MIS. Main Outcome Measures. The main outcome measures were cellular viability, proliferation, cell-cycle arrest, and induction of apoptosis and autophagy in endometriotic cells. Results. MIS treatment inhibited proliferation of endometriosis cells and induced apoptosis, as indicated by Annexin V staining, and induced caspase-9 cleavage and cell-cycle arrest, as evidenced by increased expression of p27 CDK-inhibitor. MIS treatment also induced autophagy in endometriosis cells as demonstrated by a significant increase in LC3-II induction, a hallmark of autophagy. Conclusions. MIS inhibits cell growth and induces autophagy, as well as apoptosis, in ectopic endometrial cell lines. Our results suggest that MIS may have a potential as a novel approach for medical treatment of endometriosis. Further studies may be needed to test the efficacy of MIS treatment in animal models and to develop MIS treatment specifically targeted to the endometriosis.

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Anti muellerian hormone serum levels in women with endometriosis: A case–control study

Cited by 71 publications

References 20 publications

The impact of endometrioma and laparoscopic cystectomy on serum anti-Müllerian hormone levels

The impact of endometrioma and laparoscopic cystectomy on serum anti-Müllerian hormone levels

Preoperative Serum Anti-Mullerian Hormone Level in Women with Ovarian Endometrioma and Mature Cystic Teratoma

Mullerian Inhibiting Substance Suppresses Proliferation and Induces Apoptosis and Autophagy in Endometriosis Cells In Vitro

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