Anti-mitochondrial M2 Antibodies and Myopathy

Anti-mitochondrial M2 Antibodies and Myopathy: Author's Reply

“…Although we have discussed a possible mechanism of AMA-M2-asociated myocardial involvement and supraventricular arrhythmias, it does not go beyond speculation at the present time. Based on their interest and kind response to our investigation ( 1 ), we hope that the present study will arouse the interest of many physicians, leading them to maintain continuous observation and to accumulate cases of AMA-M2-positive patients in routine clinical practice. This helps to clarify the mechanism of myocardial involvement and supraventricular arrhythmias.…”

“…The Authors Reply We would like to thank Drs. Finsterer and Zarrouk-Mahjoub ( 1 ) for their interest in our recent publication in Internal Medicine regarding the enhanced risk of supraventricular arrhythmia in patients who are positive for anti-mitochondrial M2 (AMA-M2) antibodies ( 2 ). A key statement in their letter reads, “Overall, this interesting study could be more meaningful if a prospective design would have been applied, if more clinical data would have been collected, and if patients would have been more extensively investigated for cardiac disease”.…”