Anti‐microbial resistance of <i>Salmonella</i> isolates from raw meat‐based dog food in Japan

Yukawa, Shoichiro; Uchida, Ikuo; Takemitsu, Hiroshi; Okamoto, Akira; Yukawa, Motomi; Ohshima, Seinosuke; Tsutsumi, Yutaka

doi:10.1002/vms3.739

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…Currently, non-typhoidal salmonella invasive disease most commonly occurs in infants and young children, older individuals, or immunocompromised or malnourished individuals, usually in sub-Saharan Africa, where the incidence of non-typhoidal salmonella invasive disease often exceeds 100 illnesses per 100,000 individuals per year [ 6 , 7 ]. In addition, multidrug resistant Salmonella isolates have been frequently identified from breeding farms, meat processing, and clinical trials in many countries [ 8 , 9 , 10 , 11 , 12 ], resulting in antibiotic treatment failure increasingly encountered for the emergence of pandrug-resistant isolates [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

Liang

Huang

Cui

et al. 2022

IJMS

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Effective phage cocktails consisting of multiple virus types are essential for successful phage therapy against pandrug-resistant pathogens, including Salmonella enterica serovar (S.) Typhimurium. Here we show that a Salmonella phage, F118P13, with non-productive infection and a lytic phage, PLL1, combined to inhibit pandrug-resistant S. Typhimurium growth and significantly limited resistance to phages in vitro. Further, intraperitoneal injection with this unique phage combination completely protected mice from Salmonella-induced death and inhibited bacterial proliferation rapidly in various organs. Furthermore, the phage combination treatment significantly attenuated the inflammatory response, restored the generation of CD4+ T cells repressed by Salmonella, and allowed macrophages and granulocytes to participate in immunophage synergy to promote bacterial clearance. Crucially, the non-productive phage F118P13 is less likely to be cleared by the immune system in vivo, thus providing an alternative to phage cocktail against bacterial infections.

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Section: Introductionmentioning

confidence: 99%

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

Liang

Huang

Cui

et al. 2022

IJMS

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“…enterica ser. Infantis are detected in RMBDs regularly [ 21 , 22 , 26 , 32 ]. Reports of the detection of S .…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have investigated the microbiological characteristics of RMBDs, on the one hand to assess the hygienic conditions of the feedstuff [ 4 , 5 , 9 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], and on the other hand concerning the occurrence of (food-borne) biological hazards (in particular Salmonella , Listeria monocytogenes , Campylobacter , and pathogenic E. coli ) [ 9 , 10 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ] or parasites [ 3 , 18 ], and finally also in relation to the presence and possible transmission of antibiotic resistance [ 10 , 16 , 19 , 20 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 ]. In essence, these studies highlighted that a RMBD will likely contain pathogenic bacteria, and that these bacteria or commensals can carry antibiotic resistance genes.…”

Section: Introductionmentioning

confidence: 99%

Microflora, Contents of Polyamines, Biogenic Amines, and TVB-N in Bovine Offal and Game Meat for the Raw-Feeding of Adult Dogs

Lindinger

Bauer

Dičáková

et al. 2023

Animals

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Microflora and contents of biogenic amines/polyamines and total volatile basic nitrogen (TVB-N) in 99 samples of bovine offal (red offal, n = 41 and other offal and mixes, n = 45) and wild game meat (n = 13) for raw meat-based diets (RMBD) for dogs were analyzed. Samples were bought in 11 local pet food shops and in one game-handling establishment in Austria (Lower Austria, Styria, and Vienna) in September and October 2022. Median contents (first and third quartiles in brackets) of cadaverine, histamine, tyramine, spermidine, and spermine were 20.7 [16.7; 28.6]; 25.4 [17.1; 47.2]; 18.9 [13.6; 38.9]; 15.2 [11.2; 21.2]; and 41.9 [<limit of detection; 64.5] mg/kg wet weight, respectively. The sum of putrescine + cadaverine + histamine + tyramine was >50 mg/kg in 85.9% of samples, indicating the use of low-quality ingredients or inappropriate storage conditions. However, only 10.1% of samples were determined to be not compliant with a maximum amine content proposed for pet food. Median contents of the total aerobic bacteria counts (TACs), Pseudomonas, and Enterobacteriaceae were 7.4 [6.4; 8.0]; 6.5 [5.5; 7.7]; and 4.8 [3.9; 5.6] log CFU/g, respectively, with significantly lower counts in red offal RMBD (p < 0.05). TVB-N exceeded 150 mg/kg in 87.9% of samples. The TACs and Enterobacteriaceae numbers in red offal RMBD were comparable to those in food-grade red offal after 6 days of aerobic storage at 7 °C, i.e., temperatures higher than required for food-grade offal, but acceptable for animal by-products intended for RMBD production. In 80.8% of samples, numbers of Enterobacteriaceae exceeded the EU legal limit. From 12 of these samples, Salmonellae was able to be isolated, with counts from 0.03 MPN/g to 110 MPN/g. Salmonella enterica ser. Montevideo (n = 3), and S. enterica ser. Give and S. enterica ssp. Diarizonae (n = 2 each) were the most frequently isolated, while Listeria monocytogenes was rarely recovered (2%). Whilst exposure of humans handling such pet food can be reduced by hygiene precautions, the risk remains that dogs can acquire a feed-borne salmonellosis and shed the pathogen.

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“…Ainda hoje, a prescrição do pâncreas suíno cru como forma de suplementação de enzimas digestivas para cães com IPE é uma prática empregada, porém, esta não é mais recomendada em medicina veterinária tendo em vista os malefícios que a oferta de vísceras ou carnes cruas, de qualquer fonte, pode ocasionar para os cães, como por exemplo a possibilidade de contaminação por salmonela (FINLEY; RAID-SMITH; WEESE, 2006;FREEMAN et al, 2013;DAVIES;LAWES;WALES, 2019;YUKAWA et al, 2022).…”

Section: )unclassified

>b<Perfil do alimento e variáveis nutricionais e intestinais de cães com insuficiência pancreática exócrina>/b<

Oliveira¹

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Agradeço aos Deuses e todas as forças do Universo por me guiarem até aqui da melhor forma possível, mesmo em meio as dificuldades.Aos meus pais Leni e José, por sempre apoiarem qualquer decisão, servindo de base para que eu alcance todos os meus sonhos. Aos meus irmãos Nicholas e Leonardo que sei que independente de qualquer coisa, estarão ao meu lado sempre que eu precisar. À minha avó Maria, que nunca mediu esforços para minha formação acadêmica e, a todos os integrantes da minha família. Eu amo vocês.Ao meu companheiro, melhor amigo e noivo Bruno Duarte, que nunca soltou minha mão mesmo nos piores momentos, sendo o abraço seguro nos momentos mais difíceis da minha vida, agradeço a paciência esses anos. Um abraço especial ao Eli (in memorian), com sua pergunta clássica: "Como vai o mestrado?" -Olha Eli, eu terminei!!!! Ao meu orientador Prof. Dr. Marcio Brunetto, que abriu uma porta em 2017 para um imenso mundo de possibilidades, obrigado pela confiança, paciência e amizade durante todos esses anos. E principalmente, pelos ensinamentos e orientação.Ao meu amigo Fabio Alves Teixeira, que acreditou em mim em momentos que nem eu mesmo acreditei, obrigado pelos conselhos, ensinamentos e conversas em momentos compartilhados no HOVET das 8h00 às 23h00.

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Anti‐microbial resistance of Salmonella isolates from raw meat‐based dog food in Japan

Cited by 7 publications

References 66 publications

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

Microflora, Contents of Polyamines, Biogenic Amines, and TVB-N in Bovine Offal and Game Meat for the Raw-Feeding of Adult Dogs

>b<Perfil do alimento e variáveis nutricionais e intestinais de cães com insuficiência pancreática exócrina>/b<

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