Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink

Zong, Aizhen; Zhao, Ting; Zhang, Yan; Song, Xinlei; Shi, Yikang; Cao, Hongzhi; Liu, Chunhui; Cheng, Ye; Qu, Xian‐Jun; Cao, Jun; Wang, Fengshan

doi:10.1016/j.carbpol.2012.08.050

Cited by 51 publications

(25 citation statements)

References 37 publications

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“…The apoptosis inducing activity can be another mechanism of action of SIP-S to inhibit tumor growth. Since SIP-S has been demonstrated to have significant anti-metastatic activity in vivo (Zong et al, 2013), it is believed that SIP-S can be a candidate of anti-tumor drugs that affect tumor growth and metastasis, and deserves further research.…”

Section: Resultsmentioning

confidence: 99%

“…We then prepared the sulfated SIP (SIP-S) by using chlorosulfonic acid (Geresh, Manontov, & Weinstein, 2002). Studies have shown that SIP-S has significant anti-metastatic and anti-angiogenic activities, and can also obviously inhibit metastatic tumor growth, which suggests that SIP-S may be an ideal candidate for cancer therapy (Zong et al, 2013 In the present study, we carried out experiments to investigate the anti-tumor effects of SIP-S alone and its combination with cyclophosphamide(CTX) on Sarcoma 180 (S180)-tumor bearing mice. Meanwhile the immunomodulatory activity of SIP-S was evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect

Zong

Liu

Zhang

et al. 2015

Carbohydrate Polymers

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect

Zong

Liu

Zhang

et al. 2015

Carbohydrate Polymers

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“…These signals promote tumor angiogenesis and therefore have been topic of interest (21). In addition, the blockade strategies of tumor vessel proliferation that may decrease the metastasis process have been considered for elaborating ectopic angiogenesis during tumor invasiveness (22).…”

Section: Discussionmentioning

confidence: 99%

Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9

Baharara

Amini

Musavi

2017

Iran. J. Biotechnol.

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Background: Bioactive compounds such as terpenoids, chondroitin sulfate, and polysaccharides with added value can be found in prestine marine creatures. These compounds often do have highly valuable therapeutic applications such as being antioxidant, antitumorogenic, anti-infl ammatory and anti-angiogenic. For the latter, varieties of angiogenesis factors can suppress this issue within the bodily tissues. Objectives: The anti-angiogenic and anti-metastatic capacity of a polysaccharide derived from brittle star was investigated. Material and Methods:The anti-proliferative eff ect of derived polysaccharide on umbilical vein endothelial cells (HUVEC) was measured using MTT (dimethyl thiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. The anti-angiogenic eff ect of the isolated polysaccharide was examined by Chorioallantoic membrane (CAM) assay. The transcriptional expression of VEGF (Vascular Endothelial Growth Factor) was evaluated by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). The anti-metastatic activity was investigated via scratch-wound healing assay. The levels of Paxillin and Matrix Metalloproteinase-9 (MMP-9) expression were analyzed by RT-PCR. Statistical analysis and mean comparisons (p< 0.05) were carried out by SPSS 16. Results: Our results elucidated that the brittle star isolated polysaccharide exerted a dose dependent cytotoxic eff ect on the HUVEC endothelial cells. The CAM assay exhibited potent anti-angiogenic activity in vivo. The RT-PCR analysis showed that the extracted polysaccharide (40, 60 μg.mL ) was administrated via down-regulation of paxillin and MMP-9 mRNA expression. Conclusions: Taken together, these results indicated that the polysaccharide extracted from brittle star was able to decrease the viability of the HUVEC cells, to suppress angiogenesis, and possibly act as a natural anti-angiogenic and anti-metastatic marine organic compound against angiogenesis related pathologies.

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“…It has been confirmed that trace elements are essential nutrients for tissue repair, immune, digestive function and other aspects of the role 4 . Researchers have founded that sepia ink has anti-radiation activity, antitumor activity, immunomodulatory activity, procoagulant function, etc 5 .…”

Section: Introductionmentioning

confidence: 94%

Effects of chitin and sepia ink hybrid sponge on the healing of burning wound rats and its impact on macrophages in vitro

et al. 2016

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PURPOSE:To detect whether chitin and sepia ink sponge (CS) can promote wound healing and elevate impact of CS on phagocytosis ability of macrophages. METHODS:Forty-eight rats were assigned to four groups: Normal group (Normal), negative control group (Con), chitin and sepia ink RESULTS:Comparing to Con and SG, scabs in CS group fell off and basically healed on 21 day. TGF-β 1 , IL-6, MMP-1 and Hyp were significantly increased by CS and SG comparing to Con (p < 0.05), CS had more apparently adjustment on TGF-β 1 and MMP-1 compared to SG; results in vitro indicated CS significantly promoted phagocytosis ability of macrophages reflected in TNF-α (p < 0.05).CONCLUSION: CS improved wound healing through exerting significant influences on secretion of kinds of cytokines and activating macrophages.

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Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink

Cited by 51 publications

References 37 publications

Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect

Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect

Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9

Effects of chitin and sepia ink hybrid sponge on the healing of burning wound rats and its impact on macrophages in vitro

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