Anti-M–Induced Delayed Hemolytic Transfusion Reaction

Fadeyi, Emmanuel A.; Naal, Tawfeq; Green, Mary; Simmons, Julie H; Jones, Mary Rose; Pomper, Gregory J.

doi:10.1093/labmed/lmz078

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…In human transfusion medicine, DHTRs are commonly associated with a secondary immune response and the majority of the DHTR publications revolve around sickle cell disease. There are case reports of DHTRs associated with naturally occurring alloantibodies in humans 94–97 …”

Section: Hemolytic Transfusion Reactionsmentioning

confidence: 99%

Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS). Part 1: Definitions and clinical signs

Davidow

Blois

Goy‐Thollot

et al. 2021

J Vet Emergen Crit Care

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Objective To use a systematic, evidence‐based consensus process to develop definitions for transfusion reactions in dogs and cats. Design Evidence evaluation of the literature was carried out for identified transfusion reaction types in dogs and cats. Reaction definitions were generated based on synthesis of human and veterinary literature. Consensus on the definitions was achieved through Delphi‐style surveys. Draft recommendations were made available through industry specialty listservs and comments were incorporated. Results Definitions with imputability criteria were developed for 14 types of transfusion reactions. Conclusions The evidence review and consensus process resulted in definitions that can be used to facilitate future veterinary transfusion reaction research.

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Section: Hemolytic Transfusion Reactionsmentioning

confidence: 99%

Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS). Part 1: Definitions and clinical signs

Davidow

Blois

Goy‐Thollot

et al. 2021

J Vet Emergen Crit Care

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“…In the past, the presence of non‐reactive anti‐M antibodies at 37°C was considered of little significance 16 . However, some recent case reports have highlighted acute and delayed hemolytic reactions caused by anti‐M antibodies 17,18 . While the rate of detection for anti‐M antibodies varies across different populations, it has been reported severally that they can be detected in approximately 0.02%–0.04% of blood donors 19,20 .…”

Section: Discussionmentioning

confidence: 99%

A single‐center, retrospective analysis of 17 cases of hemolytic disease of the fetus and newborn caused by anti‐M antibodies

Gao

et al. 2023

Transfusion

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Objective We aimed to summarize the laboratory findings and clinical features of hemolytic disease of the fetus and newborn (HDFN). Methods We retrospectively analyzed the data for 17 infants with anti‐M‐induced HDFN (anti‐M‐HDFN) diagnosed between June 2013 and May 2019. Their maternal history, neonatal diagnosis on admission, and laboratory test results were compared with those of 15 infants with HDFN involving the ABO blood group system, 15 infants with HDFN involving the Rh system, and 15 premature infants. Results In the anti‐M‐HDFN group, 94.12% (16/17), 35.29% (6/17), and 17.65% (3/17) had free antibodies in plasma, a positive direct antiglobulin test, and a positive elution test, respectively. In 12 infants, free antibody reactions were stronger at 4°C than at 37°C, and the antibody titer at 4°C ranged from 1 to 512. All 17 infants with anti‐M‐HDFN developed anemia: 14 were treated with blood transfusion and 1 with neonatal exchange transfusion. Sixteen infants improved, and one died. Anti‐M‐HDFN had a higher rate of maternal stillbirth, lower gestational age, lower birthweight, and higher incidence of respiratory distress than other HDFN types. Conclusion Anti‐M may cause HDFN. It may present with varying degrees of anemia, low regenerative anemia, and low bilirubin levels. In addition, infants with anti‐M‐HDFN may have a negative elution test and direct antiglobulin test. These tests are helpful in examining antibody responses at a low temperature of 4°C.

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“…A study has found that the incidence of anti-M-induced severe HDFN is extremely low ( 18 ). Anti-M antibodies in humans are divided into natural antibodies and immune antibodies, including the more common IgM properties, IgM + IgG properties, or IgG properties alone, however IgG antibodies are relatively rare ( 19 ). In this study, 93 cases of anti-M antibody positive patients had a history of pregnancy, which was the highest detection rate group, accounting for 62.4%.…”

Section: Discussionmentioning

confidence: 99%

Analysis of anti-M antibody status and blood transfusion strategy in Hunan, China

Wang¹,

Wang²,

Mo³

et al. 2022

Ann Transl Med

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Background: By analyzing the detection rate of anti-M antibody in patients with the MNS blood group system in the Hunan area, we aimed to explore its clinical significance and blood transfusion strategy. Methods:We retrospectively analyzed the clinical data of patients who had been confirmed to contain anti-M antibodies through serological methods such as the saline tube method and cassette anti-human globulin method.Results: Irregular antibody screening tests had been applied to 94,452 patients, from which 652 results were positive. Among those positive patients, 93 cases were positive for anti-M antibodies, accounting for 14.26% of the positive rate of irregular antibodies; 11 cases had a blood transfusion history, accounting for 11.8%; 59 cases had a pregnancy history, accounting for 63.4%; and 2 cases had a transplant history, accounting for 2.2%. The patients with anti-M antibodies included 23 pregnant woman, accounting for 24.7%, and 19 tumor patients, accounting for 20.4%. A total of 66 cases were immunoglobulin M (IgM) + immunoglobulin G (IgG) class, accounting for 71.0%, 26 cases were IgM class, accounting for 28.0%, and 1 case was IgG class, accounting for 1.0%. Conclusions:The detection rates of anti-M antibody in the Hunan area and unexpected antibodies in literature reports are mainly related to a pregnancy history, and the type of antibody is predominantly IgM + IgG class. The clinical significance of anti-M antibody cannot be ignored, and three media should be used for cross-matching of blood wherever possible to ensure the safety of blood transfusion.

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Anti-M–Induced Delayed Hemolytic Transfusion Reaction

Cited by 5 publications

References 9 publications

Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS). Part 1: Definitions and clinical signs

Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS). Part 1: Definitions and clinical signs

A single‐center, retrospective analysis of 17 cases of hemolytic disease of the fetus and newborn caused by anti‐M antibodies

Analysis of anti-M antibody status and blood transfusion strategy in Hunan, China

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