Anti-M Antibody in Pregnancy

Thompson, Dana; Stults, Debra Z.; Daniel, Sara Jo

doi:10.1097/00006254-198909000-00001

Cited by 17 publications

(20 citation statements)

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“…Importantly, in our case DAT analyses were negative in the newborn and/or fetus both in the second and third pregnancy. It has previously been reported that the DAT might be negative in anti‐M‐mediated hemolysis 12 . One hypothesis is that it is because of very rapid intravascular hemolysis.…”

Section: Discussionmentioning

confidence: 99%

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Fetal hemolytic anemia and intrauterine death caused by anti‐M immunization

et al. 2007

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Section: Discussionmentioning

confidence: 99%

“…It has previously been reported that the DAT might be negative in anti-M-mediated hemolysis. 12 One hypothesis is that it is because of very rapid intravascular hemolysis. Another hypothesis might be that the mechanism is similar to anti-K and anti-Ge HDFN, where erythroid progenitor cells possess Kell and Gerbich antigens.…”

Section: Discussionmentioning

confidence: 99%

Fetal hemolytic anemia and intrauterine death caused by anti‐M immunization

et al. 2007

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“…Other similar cases of clinically significant anti-M and anti-N have been reported in the literature. [9101112131415161718] Most of the authors confer that whenever M or N antibodies active at 37°C are encountered, antigen-negative or red cells compatible by an IAT should be provided. [19] In the specifications[20] outlining Red Cell Imunohematology (RCI) clinical policy for the supply of blood for transfusion to National Health Service-Blood and Transplant (NHSBT) they recommend that for anti-M reacting at 37°C, M antigen negative blood be provided, whereas for anti-N of similar nature, provision of red cells compatible by IAT at 37°C suffices.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of antibody specificities to M, N and Lewis blood group system

Makroo

Arora

Bhatia

et al. 2014

Asian J Transfus Sci

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Context:The clinically significant antibodies are those active at 37°C and/or by the indirect antiglobulin test. Most of the published literature refers to antibodies of Lewis blood group system to be insignificant, whereas antibodies to M and N blood groups are associated with variable clinical significance.Aims:The aim of this study is to find the frequency and clinical significance of antibodies to M, N and Lewis blood group systems.Settings and Design:The study was carried out retrospectively from January 2009 to December 2012.Materials and Methods:Antibody screening was performed by solid phase red cell adherence (SPRCA) technique using four cell screening panel on a fully automated platform GALILEO (Immucor Inc. USA). In case of a positive antibody screen, antibody identification was performed using SPRCA (GALILEO, Immucor Inc. USA).Results:A total of 49,077 red cell antibody screens were performed and a total of 427 identifications of red cell antibodies were carried out. A total of 304 specific antibodies were detected: 8.22% of antibodies were of anti-M specificity and 2.96% were of anti-N specificity. Majority (84%) of anti-M and 77.78% of anti-N were of Immunoglobulin G (IgG) class reacting at 37°C. 1.31% of the antibodies were directed against Lewis system antigens of which 0.65% were anti-Lea and 0.65% were anti-Leb. Half of the Lewis system antibodies, i.e., 1 each of anti-Lea and anti-Leb were of IgG class.Conclusion:Our study highlights the importance of detecting the thermal amplitude of antibodies with variable clinical significance especially if both IgG and IgM types of antibodies are associated with it so as to establish their clinical significance.

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“…It is a weak complete cold agglutinin with no reaction at 37°C 4 . Actually, 22–30% of the population lack the M antigen on their red blood cells (NN), and, therefore, are capable of producing anti‐M when exposed to the antigen 5 . However, the incidence of severe hemolytic disease of newborn due to anti‐M is extremely rare 1,4,6 .…”

Section: Discussionmentioning

confidence: 99%