Anti-Lithiatic Effect of Lycopene in Chemically Induced Nephrolithiasis in Rats

Patel, Pritash; Patel, Saumya; Patel, Veena

doi:10.22159/ajpcr.2022.v15i7.44969

Cited by 5 publications

(7 citation statements)

References 26 publications

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“…Esses casos crônicos apresentavam perfil que incluía ambiente ocupacional, sexo masculino, idade mais avançada e hábito de fumar (atual ou passado). Além disso, a maioria deles apresentou padrão obstrutivo sustentado na espirometria (89,7%), provavelmente refletindo as características patológicas relatadas nos casos de SDRA, que abarcam destruição epitelial das vias aéreas, infiltrado inflamatório linfocitário, espessamento da membrana basal e fibrose subepitelial da parede das vias aéreas 24,26,43 . Entretanto, esse achado também pode estar relacionado ao hábito de fumar, seja pelo seu efeito aditivo, que reduz os parâmetros de função das vias aéreas, seja como fator de confusão no diagnóstico de doença pulmonar relacionada ao tabagismo 13,33,44,45 .…”

Section: Discussionunclassified

“…A medição da PaO2 é utilizada para avaliar doenças respiratórias. Níveis menores desse parâmetro têm sido associados a sintomas crônicos após exposição a substâncias tóxicas inaladas, fato que provavelmente reflete danos mais extensos às vias aéreas e às estruturas alvéolo-capilares 25,43 . Em nossa revisão, apenas dois estudos mediram a PaO2 inicialmente e os resultados foram normais em ambos, apresentando maiores níveis de PaO2 e melhor evolução (resolução completa) 32,41 .…”

Section: Discussionunclassified

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Exposição ao gás cloro e padrões evolutivos da síndrome da disfunção reativa das vias aéreas: uma revisão sistemática

Vianna,

Bhering,

Silva

et al. 2023

Rev. bras. saúde ocup.

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Resumo Introdução: o cloro é o gás irritante a que as pessoas estão comumente expostas no cotidiano. Um dos seus efeitos tóxicos é a síndrome da disfunção reativa das vias aéreas (SDRA). Objetivo: resumir as principais evidências dos padrões evolutivos da SDRA. Métodos: Revisão sistemática da literatura de artigos publicados entre setembro de 1985 e julho de 2021 no repositório da Universidade de São Paulo (USP) e nas bases BVS/LILACS, PubMed/Medline e SciELO. Foram utilizados os descritores “cloro” e “asma ocupacional” associados à “síndrome da disfunção reativa das vias aéreas” ou “asma induzida por irritantes”. Dois revisores independentes selecionaram e avaliaram a qualidade dos estudos, com apoio do checklist do Instituto Joanna Briggs. Resultados: selecionaram-se 22 estudos: 11 séries de casos, oito relatos de caso e três estudos transversais. Os estudos selecionados abrangeram 1.335 participantes de 11 países, e apenas 170 tiveram diagnóstico de SDRA com evolução documentada. Destes, 115 (65%) foram devido à exposição ocupacional. Os padrões evolutivos mais frequentes foram persistência prolongada dos sintomas, alterações espirométricas e/ou hiper-responsividade brônquica, principalmente no ambiente ocupacional. Observou-se falta de padronização no relato de informações adequadas. Conclusões: a cronicidade foi o padrão evolutivo da SDRA mais frequente. Houve falta de informação apropriada que impediu uma análise adequada dos resultados.

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Section: Discussionunclassified

Exposição ao gás cloro e padrões evolutivos da síndrome da disfunção reativa das vias aéreas: uma revisão sistemática

Vianna,

Bhering,

Silva

et al. 2023

Rev. bras. saúde ocup.

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“…Physicochemical parameters suc as loss on drying, Total Ash value, acid insoluble ash value, water soluble ash value and foaming index were determined using standard procedures [11][12].…”

Section: Physicochemical Parametersmentioning

confidence: 99%

Pharmacognostical, Phytochemical and Pharmacological Evaluation for the Abortifacient Potential of the Seeds of Nigella Sativa L.

Thakur¹

2022

JASR

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Nigella sativa L (Ranunculaceae family) or commonly known as black cumin has long been used as a phytomedicine for antidiarrhea, appetite enhancer, diuretic, antibacterial, analgesic, anthelmintic, various skin diseases, anti-inflammatory, back pain, hemiplegia (paralysis of the hands or feet) and rheumatism. The objective of this study was to investigate pharmacognostical, phytochemical features, antioxidant activity and abortifacient effects of ethanol and aqueous extracts of Nigella sativa seed by using DPPH assay method and pregnancy maintenance model respectively. The different pharmacognostical parameters were evaluated as per standard protocols with some modifications. The preliminary phytochemical studies were performed with various reagents and chemicals on seed extracts in order to determine the various secondary metabolites. The ethanol and aqueous extracts of Nigella sativa seeds were screened for in-vitro antioxidant activity by oxygen radical scavenging such as 1, 1-diphenyl-2- picrylhydrazyl (DPPH) method. Abortifacient activity was studied in rats at 400 mg/kg doses administered orally from 8thto 20thdayof pregnancy. Rats were laparotomised on 21st day. Weight of fetus, percentage of abortion and thelive and dead fetuses were observed in both horns of the uterus. Pharmacognostical studies reveal the macroscopical characters of Nigella sativa seeds. Phytochemical screening of the ethanol and aqueous extracts of Nigella sativa seeds revealed the presence of secondary metabolites like alkaloids, carbohydrates, proteins and amino acids, tannins, saponins, glycosidesand flavonoids. The ethanol and aqueous extracts showed good dose dependent free radical scavenging property. IC50 values for aqueous and ethanol extracts were calculated by DPPH method. Aqueous extract have shown more free radical scavenging power as compared to ethanol extract. Ascorbic acid was used as standard. In this experiment, abortion is induced by using pregnancy maintenance model. In contrast, no live foetus was recorded in the animals treated with mifepristone as well as the 400 mg/kg, p.o. body weight of the ethanolic and aqueous extract having live foetus. Whereas ethanolic and aqueous extract having dead foetus and there was no dead foetus in the mifepristone treated animals. The ethanolic and aqueous extract of Nigella sativa at doses of 400 mg/kg has abortifacient effects, supporting its uses in traditional medicine. Further studies on the isolation of bioactive phytoconstituents of Nigella sativaseeds and their mechanism of action are strongly recommended before its application to humans.

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“…The decoction was poured in test tube, and then shaken in a lengthwise motion for 15 seconds. They were allowed stand for 15 minutes and the height of foam was measured to determine the foaming index [19,20].…”

Section: Foaming Indexmentioning

confidence: 99%

Pharmacognostical, Phytochemical and Antioxidant Potential of Hydroalcoholic Extract of Hordeum Vulgare Linn Seed

Kossar¹,

Khan²,

Khare³

et al. 2022

JASR

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Plants have served human beings as a natural source for treatments and therapies from ancient times, amongst them medicinal herbs have gain attention because of its wide use and less side effects. In the recent years plant research has increased throughout the world and a huge amount of evidences have been collected to show immense potential of medicinal plants used in various traditional systems. Hordeum vulgare Linn seeds (H. vulgare, Commonly known as barley, Family: Poaceae), is an erect annual herb, 50 to 100 cm high, cultivated in the plains as well as in the hilly region of Himalaya, up to an altitude of 4000 m, in Indo- Gangetic area and Madhya Pradesh. It is locally called Jav and its seed used by traditional medical practitioners in the treatment of many diseases including liver diseases. Seeds are useful in vitiated conditions of kapha and pitta, asthma, fever, bronchiotitis, urocystitis, urethritis, gastric disorders, ulcers and anemia etc. The objective of this study was to investigate pharmacognostical, phytochemical features and antioxidant activity of hydroalcoholic extracts of H. vulgare seed by using DPPH assay method. The different pharmacognostical parameters were evaluated as per standard protocols with some modifications. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenol and flavonoids were determined by the well-known test protocol available in the literature. Quantitative analysis of phenolic and flavonoids was carried out by Folins Ciocalteau reagent method and aluminium chloride method respectively. The in vitro antioxidant activity of hydroalcoholic extract of the seed was assessed against DPPH method using standard protocols. Phytochemical analysis revealed the presence of alkaloids, glycosides, flavonoids, steroids, saponins and carbohydrate. The total phenolic and flavonoids content of H. vulgare seed of hydroalcoholic extract was 0.693 and 0.497mg/100mg respectively. The activities of hydroalcoholic leaves extract against DPPH assay method were concentration dependent with IC 50 values of ascorbic acid and extracts 27.82 and 76.92μg/ml respectively. These studies provided information for correct identification of this plant material. The diverse array of phytochemicals present in the plant thus suggests its therapeutic potentials which may be explored in drug manufacturing industry as well as in traditional medicine.

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Anti-Lithiatic Effect of Lycopene in Chemically Induced Nephrolithiasis in Rats

Cited by 5 publications

References 26 publications

Exposição ao gás cloro e padrões evolutivos da síndrome da disfunção reativa das vias aéreas: uma revisão sistemática

Exposição ao gás cloro e padrões evolutivos da síndrome da disfunção reativa das vias aéreas: uma revisão sistemática

Pharmacognostical, Phytochemical and Pharmacological Evaluation for the Abortifacient Potential of the Seeds of Nigella Sativa L.

Pharmacognostical, Phytochemical and Antioxidant Potential of Hydroalcoholic Extract of Hordeum Vulgare Linn Seed

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