Anti-leukemic effects of the quercetin on human leukemia U937 cells mediated by down-regulation of Mcl-1, survivin, and XIAP

Rahbaran, Mohaddeseh; Razeghian, Ehsan

doi:10.4993/acrt.29.55

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…Up to now, various factors involved in the pathogenesis of the disease were identified, however, the main cause of the disease has not been identified. Recent studies showed that inflammation caused by immune cells, especially macrophages, plays an important role in the development and progression of the disease (Nokhostin et al, 2020; Mohaddeseh Rahbaran & Ehsan Razeghian, 2021; Tanaka & Miyajima, 2016). Polarizing macrophages towards M1 and M2 plays an important role in developing and controlling liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Liver fibrosis is an inflammatory disease that manifests in the late stages of liver disorders. The progression of fibrosis leads to liver failure, hepatocarcinoma, and eventually death (Mohaddeseh Rahbaran & Ehsan Razeghian, 2021, Tacke & Zimmermann, 2014). The activation of immune cells, especially macrophages, plays an important role in the pathogenesis of this disease (Mosser & Edwards, 2008; Tacke & Zimmermann, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…In humans, M1 phenotypes are identified by the expression of CD14, CD16, and CCR2 markers. While M2 macrophages are characterized by CD14 and CD16 expression and lack of CCR2 expression (Martinez & Gordon, 2014). In contrast, there are macrophages M1 and M2 in mice, which are distinguished by the expression of CCR2 and Ly6C.…”

mentioning

confidence: 99%

“…development and progression of the disease(Nokhostin et al, 2020;Mohaddeseh Rahbaran & Ehsan Razeghian, 2021;Tanaka & Miyajima, 2016). Polarizing macrophages towards M1 and M2 plays an important role in developing and controlling liver fibrosis.…”

mentioning

confidence: 99%

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The effect of mesenchymal stem cells and imatinib on macrophage polarization in rat model of liver fibrosis

Malmir

Farivar

Rezaei

et al. 2022

Cell Biology International

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Liver fibrosis is a disorder in which inflammatory reactions play an important role, and central to the progression and pathogenesis of this disease are the immunespecific cells known as macrophages. Macrophage types are distinguished from each other by the expression of a series of surface markers. STAT6 and Arg1 play an important role in the polarization of macrophages, so these two factors are downstream of interleukin 4 (IL-4) and IL-13 cytokines and cause to differentiate M2. Therefore, this study aimed to compare the independent effects of imatinib and mesenchymal cell treatment on the polarization of macrophages in rat models of liver fibrosis. The liver fibrosis was induced by the injection of CCL4 for 6 weeks in Sprague-Dawley rats. Then, rats were divided into four different groups, and the effects of imatinib and mesenchymal cells on the expression of Arg1, Ly6c, and STAT6 were evaluated. Histopathology experiments considered the amelioration effect of treatments. Our results showed that Arg1 expression was significantly increased in the groups treated with mesenchymal cells and imatinib compared to the control group. On the other hand, expression of STAT6 was significantly increased in the imatinib-treated mice compared to mesenchymal and control groups. Moreover, the expression of LY6C significantly decreased in imatinib and mesenchymal treated groups compared to the control group. Therefore, our data showed that mesenchymal stem cells and imatinib significantly modulate the fibrotic process in rat models of fibrosis, probably by polarizing macrophages towards an anti-inflammatory profile and increasing the frequency of these cells in liver tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The effect of mesenchymal stem cells and imatinib on macrophage polarization in rat model of liver fibrosis

Malmir

Farivar

Rezaei

et al. 2022

Cell Biology International

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“…The conversion of LC3-I cells to LC3-II cells and the presence of autophagy markers such as P13K, Beclin-1, Atg5-Atg12 and Atg7 have been observed [32]. The ability of quercetin to induce cell cycle arrest [45], ERK signalling activation [52], Akt-mTOR phosphorylation [32] and the downregulation of Mcl-1, survivin and XIAP genes contribute to its potential in treating haematological malignancies [53].…”

Section: Quercetinmentioning

confidence: 99%

Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review

Iweala

Oluwapelumi

Dania

et al. 2023

Life

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Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues which represents approximately 10% of all cancers. It has been reported that approximately 60% of all blood cancers are incurable. Despite substantial improvement in access to detection/diagnosis, chemotherapy and bone marrow transplantation, there is still high recurrence and unpredictable but clearly defined relapses indicating that effective therapies are still lacking. Over the past two decades, medicinal plants and their biologically active compounds are being used as potential remedies and alternative therapies for the treatment of cancer. This is due to their anti-oxidant, anti-inflammatory, anti-mutagenic, anti-angiogenic, anti-cancer activities and negligible side effects. These bioactive compounds have the capacity to reduce proliferation of haematological cancers via various mechanisms such as promoting apoptosis, transcription regulation, inhibition of signalling pathways, downregulating receptors and blocking cell cycle. This review study highlights the mechanistic and beneficial effects of nine bioactive compounds (quercetin, ursolic acid, fisetin, resveratrol, epigallocatechin gallate, curcumin, gambogic acid, butein and celastrol) as potential remedies for chemoprevention of haematological cancers. The study provides useful insights on the effectiveness of the use of bioactive compounds from plants for chemoprevention of haematological cancers.

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Electrospun nanocarriers for delivering natural products for cancer therapy

Mohammadinejad

Madamsetty

Kumar

et al. 2021

Trends in Food Science & Technology

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Anti-leukemic effects of the quercetin on human leukemia U937 cells mediated by down-regulation of Mcl-1, survivin, and XIAP

Cited by 4 publications

References 27 publications

The effect of mesenchymal stem cells and imatinib on macrophage polarization in rat model of liver fibrosis

The effect of mesenchymal stem cells and imatinib on macrophage polarization in rat model of liver fibrosis

Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review

Electrospun nanocarriers for delivering natural products for cancer therapy

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