Anti‐leukemic and anti‐angiogenic effects of <scp>d</scp>‐Limonene on K562‐implanted C57<scp>BL</scp>/6 mice and the chick chorioallantoic membrane model

Shah, Bhavini; Baksi, Ruma; Chaudagar, Kiranj; Nivsarkar, Manish; Mehta, Abhishek

doi:10.1002/ame2.12039

Cited by 17 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…D-limonene metabolites have been detected in adipose tissue and mammary glands in a high concentration, although it has low toxicity [101]. This compound shows different pharmacological properties, which include anti-inflammatory, gastro-protective, anti-nociceptive, anti-tumor, and neuroprotective [102][103][104]. A recent study has demonstrated D-limonene anti-tumor activity (i.e., tumor cells decreased in proliferation and growth) in an animal model of chronic myeloid leukemia [102].…”

Section: D-limonenementioning

confidence: 99%

“…This compound shows different pharmacological properties, which include anti-inflammatory, gastro-protective, anti-nociceptive, anti-tumor, and neuroprotective [102][103][104]. A recent study has demonstrated D-limonene anti-tumor activity (i.e., tumor cells decreased in proliferation and growth) in an animal model of chronic myeloid leukemia [102]. Moreover, D-limonene also showed anti-inflammatory activity by inhibiting pro-inflammatory mediators, leukocyte migration, and vascular permeability [105].…”

Section: D-limonenementioning

confidence: 99%

See 1 more Smart Citation

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

View full text Add to dashboard Cite

Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9-tetrahydrocannabinol (Δ9-THC)—as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from Cannabis sativa. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.

show abstract

Section: D-limonenementioning

confidence: 99%

Section: D-limonenementioning

confidence: 99%

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Several experiments have been carried out for demonstrating the anticancer property of limonene. Limonene has shown anti-leukemic and anti-angiogenic property against chronic myeloid leukemia (CML) (Shah et al, 2018). CML causes rapid increase in the counts of white blood cell (WBC), lymphocytes (LY) and neutrophils (NE) whereas reduces the hemoglobin (Hb) content and number of red blood cells (RBC) (Shah et al, 2018).…”

Section: Anti-cancer Activitymentioning

confidence: 99%

“…Limonene has shown anti-leukemic and anti-angiogenic property against chronic myeloid leukemia (CML) (Shah et al, 2018). CML causes rapid increase in the counts of white blood cell (WBC), lymphocytes (LY) and neutrophils (NE) whereas reduces the hemoglobin (Hb) content and number of red blood cells (RBC) (Shah et al, 2018). Treatment of murine models of CML with d-limonenedecreased the counts WBC, LY and NE and increased the Hb content and RBC counts.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Response of Orchid Cut Flowers as Affected by Floral Preservatives on the Postharvest Quality

Muraleedharan¹,

Sha²,

Kumar³

et al. 2021

PLANT ARCHIVES

View full text Add to dashboard Cite

Citrus rinds contain a tremendous amount of essential oils. The peels contain majority of the essential oils that are continuously wasted. One of the major constituents of the essential oils in the zest of different citrus fruits like orange, tangerine, lemon and grapefruit is limonene. The review aims at discussing various conventional and novel extraction methods of limonene from citrus fruits. The review also discusses various therapeutic properties of limonene and the mechanism behind these properties. Limitations in the use of limonene such as toxicity and side-effects will be delineated. Limonene is present in the range of 26.9-97.83% in the citrus essential oils. The percentage of limonene in the essential oil depends on the Citrus species and extraction methodology. There are different extraction methods such as hydrodistillation, steam distillation, cold pressing, microwave-assisted extraction, ultrasound sound assisted extraction and supercritical fluid extraction. Various therapeutic potential of limonene has been reported. Limonene is usually non-toxic but its epoxides can be toxic at the very high dose. This up to date and comprehensive review aims to provide a valuable overview of limonene and its therapeutic potential.

show abstract

“…[ 2 ] Previous studies have reported that D-Limonene is cytotoxic to cancer cells but not to hepatocytes. [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Identification of active compounds in ethyl acetate, chloroform, and N-hexane extracts from peels of Citrus aurantifolia from Maribaya, West Java, Indonesia

Asmah

Suniarti

Margono

et al. 2020

J Adv Pharm Technol Res

View full text Add to dashboard Cite

Lime peel contains essential oils are used as anti-oxidants or anti-cancer compounds. As a traditional medicine, lime has been widely used as a substitute for antibiotics. This study aimed to identify active compounds in peel extracts from Citrus aurantifolia that grows in Indonesia. Extraction was carried out by maceration using three different solvents: ethyl acetate, chloroform, and n-hexane. The extracts were analyzed using gas chromatography-mass spectrometry. The results showed that lime peel contained many important compounds and that 28, 27, and 24 different chemical compounds, both minor and major constituents, were extracted by ethyl acetate, chloroform, and n-hexane, respectively. Four compounds were found in all three solvent extracts, namely, D-limonene, phytol, α-tocopherol, and 5, 7-dimethoxycoumarin. Forty-seven compounds were uniquely present in one solvent, including 17 in ethyl acetate, 17 in chloroform, and 13 in n-hexane. Among the active compounds extracted, several are of biological importance, for example, stigmasterol, D-limonene, Vitamin E, and α-tocopherol. It can be concluded that a variety of distinct compounds are extracted from the same lime peel sample when different solvents are used and that some of these are bioactive compounds with anti-oxidant, anti-microbial, or anti-cancer properties.

show abstract

Anti‐leukemic and anti‐angiogenic effects of d‐Limonene on K562‐implanted C57BL/6 mice and the chick chorioallantoic membrane model

Cited by 17 publications

References 25 publications

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

Response of Orchid Cut Flowers as Affected by Floral Preservatives on the Postharvest Quality

Identification of active compounds in ethyl acetate, chloroform, and N-hexane extracts from peels of Citrus aurantifolia from Maribaya, West Java, Indonesia

Contact Info

Product

Resources

About