Herbs and derived medicines are traditionally practiced in many regions worldwide. The components present in the plant are known as secondary metabolites that have many effective properties against several diseases. Herbal medicines are the complex of the components of the herbs that are prepared and used in alleviating infections in the diseases. Leukemia is a type of blood cancer that develops in the blood-forming tissues such as bone marrow and is found to be in forms such as lymphocytic leukemia and myeloid leukemia. This blood-related disorder develops in the blood-forming tissues by the accumulation of improperly differentiated cells and may spread to other related areas in treatment delay. The conventional treatment for this disease is effective but at a cost. So herbal medicines can be one of the effective treatments for leukemia. Therefore, the following chapter is going to be about the herbs and herbal medicine and its usage for leukemia. It will also focus on the medicinal properties such as apoptotic, anti-inflammation, and others, and their future perspectives.