“…4-Amino-2-aryl-6,9-dichlorobenzo[g]pteridines 237 (Figure 24) synthesized from 5,8-dichloro-2,3-dicyanoquinoxaline, have been reported as micromolar inhibitors of TNF-α and interleukin-6 (IL-6) 127 and to have anti-leukemic activity against HL60 and K562 cell lines. 262 Pteridine 2,4diamine derivatives act as antioxidants via radical scavenging and lipoxygenase inhibition, down to 100 nM. The analogues with the best profile (339 and 340) exhibited some efficacy in preventing tissue damage in a rat model of colitis and one analogue exhibited greater efficacy than indomethacin in a paw edema model.…”