Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-d-glucan

Jin, Yifei; Cai, Liqin; Yang, Qian; 羅, 志偉; Li, Liang; Liang, Yuxing; Wu, Balu; Ding, Liang; Zhang, Dongdong; Xu, Xiaojuan; Zhang, Lina; Zhou, Fuling

doi:10.1016/j.carbpol.2020.116329

Cited by 46 publications

(32 citation statements)

References 51 publications

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“…62 The plant-based SeNPs because of their non-toxic nature, excellent biocompatibility and unique bioactive properties can be one of the alternative strategies to control these devastating diseases. 5,17,41,72 In recent literature, the plant-based SeNPs have been explored to control the larva of mosquitoes. In another study, it was revealed that Dillenia indica leaf extract mediated SeNPs are effective against mosquito vectors such as Aedes aegypti and Culex quinquefasciatus.…”

Section: Dovepressmentioning

confidence: 99%

“…3,4 Selenium also plays a significant role in the iodine and peroxides metabolism in the body, regulates the level of iodine and free radicals, and can enhance disease resistance. 5,6 The deficiency of selenium disturbs the cellular equilibrium between oxidants and antioxidants, which can exacerbate the oxidation-associated risks, especially when the body is challenged by severe oxidative stresses. 3,4 Many hepatic degenerative diseases caused by the deposition of toxic elements, heavy metals, alcohol consumption, and administration of chemotherapeutic drugs can be attenuated by the consumption of selenium supplements.…”

Section: Introductionmentioning

confidence: 99%

“…It was demonstrated that the biosynthesized SeNPs significantly inhibit the proliferation of the acute myeloid leukemia cells (AML) by increasing the antioxidant potential of AML cells and delimit the expression of c-Jun activation domain-binding protein 1 and thioredoxin 1. 5 Another mechanism responsible for the anti-leukemia potential of SeNPs involves the effective removal of the free radicals by selenium nanoparticles, thus inhibit the lipid peroxidation induced by free radicals ( Figure 5). 15 Unfortunately, only a few studies have reported the anticancer potential of the plant-based SeNPs on human AML cells.…”

mentioning

confidence: 99%

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Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

Ikram¹,

Javed²,

Raja³

et al. 2021

IJN

154

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Section: Dovepressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

Ikram¹,

Javed²,

Raja³

et al. 2021

IJN

154

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“…Some clinical trials showed selenium and vitamin C supplementation could decrease the incidence and mortality of gastric and lung cancer [ 52 , 53 ]. One study demonstrated selenium exerted antileukemia effect by increasing antioxidant capacity [ 54 ]. A previous study showed that AZA exhibited antitumor effects against melanoma by inhibiting ROS generation and reducing oxidative tissue injury [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway

Zhang

羅

Jin

et al. 2020

Oxidative Medicine and Cellular Longevity

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Acute myeloid leukemia (AML) is a hematological malignancy with a poor prognosis attributed to elevated reactive oxygen species (ROS) levels. Thus, agents that inhibit ROS generation in AML should be exploited. Azelaic acid (AZA), a small molecular compound, can scavenge ROS and other free radicals, exerting antitumor effects on various tumor cells. Herein, this study evaluated the antileukemic activity of AZA against AML via regulation of the ROS signaling pathway. We found that AZA reduced intracellular ROS levels and increased total antioxidant capacity in AML cell lines and AML patient cells. AZA suppressed the proliferation of AML cell lines and AML patient cells, expending minimal cytotoxicity on healthy cells. Laser confocal microscopy showed that AZA-treated AML cells surged and ruptured gradually on microfluidic chips. Additionally, AZA promoted AML cell apoptosis and arrested the cell cycle at the G1 phase. Further analysis demonstrated that peroxiredoxin (Prdx) 2 and Prdx3 were upregulated in AZA-treated AML cells. In vivo, AZA prolonged survival and attenuated AML by decreasing CD33+ immunophenotyping in the bone marrow of a patient-derived xenograft AML model. Furthermore, mice in the AZA-treated group had an increased antioxidant capacity and Prdx2/Prdx3 upregulation. The findings indicate that AZA may be a potential agent against AML by regulating the Prdxs/ROS signaling pathway.

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“…For instance, Jin et al prepared SeNPs embedded and homogeneously dispersed in black fungus-extracted BFP nanotubes (triple helix β-(1,3)-D-glucan) that possess hydrophilic hydroxyl groups. These nanocomposites showed interesting cytotoxic and antitumor properties [188].…”

Section: Using Fungimentioning

confidence: 99%

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Zambonino

Quizhpe

Jaramillo

et al. 2021

IJMS

107

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The synthesis and assembly of nanoparticles using green technology has been an excellent option in nanotechnology because they are easy to implement, cost-efficient, eco-friendly, risk-free, and amenable to scaling up. They also do not require sophisticated equipment nor well-trained professionals. Bionanotechnology involves various biological systems as suitable nanofactories, including biomolecules, bacteria, fungi, yeasts, and plants. Biologically inspired nanomaterial fabrication approaches have shown great potential to interconnect microbial or plant extract biotechnology and nanotechnology. The present article extensively reviews the eco-friendly production of metalloid nanoparticles, namely made of selenium (SeNPs) and tellurium (TeNPs), using various microorganisms, such as bacteria and fungi, and plants’ extracts. It also discusses the methodologies followed by materials scientists and highlights the impact of the experimental sets on the outcomes and shed light on the underlying mechanisms. Moreover, it features the unique properties displayed by these biogenic nanoparticles for a large range of emerging applications in medicine, agriculture, bioengineering, and bioremediation.

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Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-d-glucan

Cited by 46 publications

References 51 publications

Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

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