Anti-Leishmania titers and positive skin tests in patients cured of kala-azar

Viana, Graça Maria C.; Nascimento, Maria do Desterro Soares Brandão; Neto, João Arnaud Diniz; Rabelo, Érica Milena Fernandes; Júnior, José Roberto Binda; Júnior, Onildo Martins Santos; Santos, Alessandro Carvalho dos; Galvão, Clarissa; Guimarães, Rafael Lima

doi:10.1590/s0100-879x2010007500134

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…The LST is often used as a measure of the protective immunity and shows a variable duration. 98% (42/43) of subjects were still LST positive 10 years post-cure from L. infantum in Maranhão, Brazil (Viana et al, 2011).…”

Section: Natural History Of Vl Diseasementioning

confidence: 99%

Progress in the Mathematical Modelling of Visceral Leishmaniasis

Rock¹,

Quinnell²,

Medley³

et al. 2016

Advances in Parasitology

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The leishmaniases comprise a complex of diseases characterised by clinical outcomes that range from self-limiting to chronic, disfiguring and stigmatising, to life-threatening. Diagnostic methods, treatments, and vector and reservoir control options exist, but deciding the most effective interventions requires a quantitative understanding of the population level infection and disease dynamics. The effectiveness of any set of interventions has to be determined within the context of operational conditions, including economic and political commitment. Mathematical models are the best available tools for studying quantitative systems crossing disciplinary spheres (biology, medicine, economics) within environmental and societal constraints.In 2005, the World Health Assembly and government health ministers of India, Nepal, and Bangladesh signed a Memorandum of Understanding to eliminate the life threatening form of leishmaniasis, visceral leishmaniasis (VL), on the Indian subcontinent by 2015 through a combination of early case detection, improved treatments, and vector control. The elimination target is <1/10,000 population at the district or subdistrict level compared to the current 20/10,000 in the regions of highest transmission.Towards this goal, this chapter focuses on mathematical models of VL, and the biology driving those models, to enable realistic predictions of the * Corresponding author Email address: orin.courtenay@warwick.ac.uk (Orin Courtenay)Preprint submitted to Advances in Parasitology July 18, 2016 best combination of interventions. Several key issues will be discussed which have affected previous modelling of VL and the direction future modelling may take. Current understanding of the natural history of disease, immunity (and loss of immunity), as well as stages of infection and their durations are considered particularly for humans, but also for dogs. Asymptomatic and clinical infection are discussed in the context of their relative roles in Leishmania transmission, as well as key components of the parasite-sandfly-vector interaction and intervention strategies including diagnosis, treatment and vector control. Gaps in current biological knowledge and potential avenues to improve model structures and mathematical predictions are identified. Underpinning the marriage between biology and mathematical modelling, the content of this chapter represents the first step towards developing the next generation of models for VL.

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Section: Natural History Of Vl Diseasementioning

confidence: 99%

Progress in the Mathematical Modelling of Visceral Leishmaniasis

Rock¹,

Quinnell²,

Medley³

et al. 2016

Advances in Parasitology

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“…It has been shown that antibody titers decline sharply over time, with or without VL treatment. 25 Therefore, it is possible that some children in our study had been exposed to leishmania infections.…”

Section: Discussionmentioning

confidence: 98%

The concurrent occurrence of Leishmania chagasi infection and childhood acute leukemia in Brazil

Vasconcelos

Azevedo-Silva

Thuler

et al. 2014

Revista Brasileira de Hematologia e Hemoterapia

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ObjectiveThis study investigated the co-existence of Leishmania chagasi infection and childhood leukemia in patients naïve to treatment; this has serious clinical and epidemiological implications.MethodsThe seroprevalence of L. chagasi antibodies prior to any treatment was investigated in children with clinical features of acute leukemia. Serological tests were performed in 470 samples drawn from under 14-year-old children from different regions of Brazil with clinical suspicion of acute leukemia. Acute leukemia subtypes were characterized by immunophenotyping using flow cytometry. Morphological analyses of bone marrow aspirates were systematically performed to visualize blast cells and/or the formation of L. chagasi amastigotes. Data analysis used a standard univariate procedure and the Pearson's chi-square test.ResultsThe plasma of 437 children (93%) displayed antibodies against L. chagasi by indirect immunofluorescence assay and enzyme-linked immunosorbent assay tests. Of the 437 patients diagnosed from 2002 to 2006, 254 had acute lymphoblastic leukemia, 92 had acute myeloid leukemia, and 91 did not have acute leukemia. The seroprevalence of L. chagasi antibodies according to the indirect immunofluorescence assay test (22.5%) was similar in children with or without acute leukemia (p-value = 0.76). The co-existence of visceral leishmanasis and acute leukemia was confirmed in 24 children. The overall survival of these children was poor with a high death rate during the first year of leukemia treatment.ConclusionIn the differential diagnosis of childhood leukemia, visceral leishmanasis should be considered as a potential concurrent disease in regions where L. chagasi is endemic.

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“…São vistos como imunocompetentes acusando a fase ativa da doença. 32,237 Bearman et al 287 mostraram a grande variabilidade entre os observadores existentes quando o tuberculínico é lido diretamente no braço do paciente, por palpação. Com os estudos de Bearmam, Sokal 239 propôs a metodologia de demarcação da área endurada com uma caneta esferográfica, sugerindo assim a facilidade do teste por qualquer profissional treinado, reduzindo a variabilidade entre os observadores.…”

Section: Teste Intradérmico De Montenegro (Idrm) E Suas Aplicaçõesunclassified

Análise epidemiológica da Leishmaniose visceral humana no Brasil: contribuição as políticas de controle

Lane¹

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serem o alicerce necessário e aplausos em minhas conquistas.vi "Por vezes sentimos que aquilo que fazemos não é senão uma gota de água no mar. Mas o mar seria menor se lhe faltasse uma gota" (Madre Teresa de Calcutá)vii AGRADECIMENTOSAgradeço a todos que de alguma maneira contribuíram para elaboração deste trabalho:Ao meu orientador, Prof. Dr. Vitor Laerte Pinto Júnior, pelos valiosos ensinamentos, paciência e dedicação no decorrer da elaboração da tese. A ele, minha admiração, por ser um exemplo de profissionalismo.À Diretoria de Atenção Primária-DIRAPS do Hospital Regional de Sobradinho, em especial ao Dr. Cleiton e a Enfermeira Iris Silva, por oportunizar a execução de parte deste trabalho.Às equipes da estratégia Saúde da Família-ESF, da região administrativa da Fercal -DF: comunidades do Engenho Velho,Queima Lençol e Rua do Mato, pelo apoio técnico no trabalho de campo.À Drª Isabele Barbieri Santos, pelas discussões e incentivo na elaboração deste trabalho.Ao Prof. Dr. Cesar Carranza-Tamayo, pelas discussões e apoio ao trabalho.À Drª Denise Furlanetto, pelo apoio e incentivo na reta final deste trabalho. À CAPES, pelo financiamento, com a concessão de bolsa de estudos.Aos membros da banca, pela cordialidade, de terem aceitado participar da discussão da minha tese.Às minhas amigas, Norma Paes Santos e Cristiane Citadin, pela amizade verdadeira de sempre.Aos meus pais, pelo apoio incondicional e por sempre ter valorizado a minha formação.Aos meus irmãos, Pedro José de Moura Júnior e Alexandre Fragoso de Moura pelo apoio necessário.Ao meu esposo, Marcus Vinícius Lane de Abreu, pelo companheirismo. Amo-te! Ao meu filho e príncipe, Arthur Fragoso de Abreu, que apesar de pequeno, é luz em muitos momentos e de uma compreensão admirável.Por fim, a Deus pela oportunidade de executar este trabalho, vencer obstáculos e superar os desafios.

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Anti-Leishmania titers and positive skin tests in patients cured of kala-azar

Cited by 9 publications

References 8 publications

Progress in the Mathematical Modelling of Visceral Leishmaniasis

Progress in the Mathematical Modelling of Visceral Leishmaniasis

The concurrent occurrence of Leishmania chagasi infection and childhood acute leukemia in Brazil

Análise epidemiológica da Leishmaniose visceral humana no Brasil: contribuição as políticas de controle

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