Anti-laminin-gamma 1 Pemphigoid with Generalized Pustular Psoriasis and Psoriasis Vulgaris

Fujimura, Yoshihiko; Natsuga, Ken; Hamade, Yohei; Nomura, Yukiko; Kaku, Yo; Muramatsu, Ryuichi; Shimizu, Hiroshi

doi:10.2340/00015555-2168

Cited by 11 publications

(16 citation statements)

References 9 publications

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“…This compares to an incidence of psoriasis in common bullous pemphigoid of between 2 and 5%, which is comparable to the normal population [48]. Of the 6 case reports of antilaminin pemphigoid published so far this year (2015), 5 have had coexisting psoriasis [49][50][51][52][53][54]. Plaque, pustular and erythrodermic psoriasis have all been reported in association with antilaminin pemphigoid [46,53].…”

Section: Anti-ϒ Laminin Pemphigoid and Psoriasis An 'Extreme' Associmentioning

confidence: 70%

A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis

McFadden

Kimber

2015

Scand J Immunol

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We have previously reviewed alterations to basement membrane laminin in psoriasis and how disruption of this layer could lead to at least some of the pathological changes observed. We here postulate that basement membrane laminin is the key antigen in driving psoriasis, inducing a T cell-mediated autoimmune response. For laminin to be considered as the key autoantigen in psoriasis, it would be reasonable to expect the following to be demonstrable: (1) that autoantigens are present in psoriatic inflammation; (2) that basement membrane laminin is perturbed in involved and uninvolved skin, and that some of the pathological changes associated with psoriasis could be predicted as a sequel to this; (3) that disruption of the basement membrane is among the earliest events in the evolution of psoriatic lesions; (4) that as streptococcal pharyngitis is the most clearly defined event to trigger or exacerbate psoriasis, then a T cell-mediated autoimmune response to laminin should be anticipated as a potential sequelae to streptococcal pharyngitis; (5) that T cells in psoriasis can be shown to react to peptides with homology to laminin; (6) that HLACw6, as the most closely related gene associated with psoriasis and which is involved in antigen expression, should be preferentially expressed within lesional psoriasis towards the basement membrane, together with other proximal associated immune activity; and (7) that there is some association between antilaminin pemphigoid, a humorally mediated autoimmune disease to skin basement membrane laminin, and psoriasis. We here review the data relevant to each of these requirements.

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Section: Anti-ϒ Laminin Pemphigoid and Psoriasis An 'Extreme' Associmentioning

confidence: 70%

A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis

McFadden

Kimber

2015

Scand J Immunol

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“…Associated conditions include hypoparathyroidism, pemphigoid and ulcerative colitis . The latter could also be related to corticosteroid treatment, which may cause flares of GPP.…”

Section: Aetiologymentioning

confidence: 99%

“…6 In the paediatric population, children with concomitant psoriasis vulgaris may have flares caused by corticosteroid withdrawal, whereas children without psoriasis vulgaris usually have flares precipitated by infection, namely streptococcal pharyngitis. 7 Associated conditions include hypoparathyroidism, 30 pemphigoid 32 and ulcerative colitis. 33 The latter could also be related to corticosteroid treatment, which may cause flares of GPP.…”

Section: Aetiologymentioning

confidence: 99%

Generalized pustular psoriasis: a review and update on treatment

Hoegler

John

Handler

et al. 2018

Acad Dermatol Venereol

138

193

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Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in its pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis and acrodermatitis continua of Hallopeau. Treatment is not well established, but includes the use of retinoids, methotrexate, cyclosporine, corticosteroids, TNF-alpha inhibitors, topical therapy and phototherapy. The use of TNF-alpha inhibitors may result in the formation of antidrug antibodies and should be administered with methotrexate.

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“…In this case, we analyzed the presence of these mutations, but the mutations were not identified in either gene. In another report, mutations in these genes were not found in a patient with laminin γ 1 pemphigoid and GPP . However, pathogenic mutation in these genes could not be identified in some patients with GPP.…”

mentioning

confidence: 93%

“…All cases with BP and GPP have been reported in Japan, and most patients with AIBD and GPP were Japanese . GPP cases without psoriasis vulgaris (PV) are linked to IL36RN mutations .…”

mentioning

confidence: 99%

Generalized pustular psoriasis complicated with bullous pemphigoid

et al. 2018

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References1 Wang H, Qiao S, Zhang X, et al. A case of pyodermatitispyostomatitis vegetans. Am J Med Sci 2013; 345: 168-171. 2 Dodd EM, Howard JR, Dulaney ED, et al. Pyodermatitispyostomatitis vegetans associated with asymptomatic inflammatory bowel disease. Int J Dermatol 2017; 56: 1457-1459. 3 Mesquita Kde C, Igreja AC. Pyodermatitis-pyostomatitis vegetans: a differential diagnosis of pemphigus vegetans. An Bras Dermatol 2012; 87: 339. 4 Abellaneda C, Mascar o JM Jr, V azquez MG, et al. All that glitters is not pemphigus: Pyodermatitis-pyostomatitis vegetans misdiagnosed as IgA pemphigus for 8 years. Am J Dermatopathol 2011; 33: e1-e6. 5 Wolz MM, Camilleri MJ, McEvoy MT, et al. Pemphigus vegetans variant of IgA pemphigus, a variant of IgA pemphigus and other autoimmune blistering disorders. Am J Dermatopathol 2013; 35: e53-e56. 6 Stingeni L, Tramontana M, Bassotti G, et al. Pyodermatitispyostomatitis vegetans and antibullous pemphigoid antigen 180 autoantibodies: a causal association? Br J Dermatol 2015; 172: 811-813. 7 Ahn BK, Kim SC. Pyodermatitis-pyostomatitis vegetans with circulating autoantibodies to bullous pemphigoid antigen 230.

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Anti-laminin-gamma 1 Pemphigoid with Generalized Pustular Psoriasis and Psoriasis Vulgaris

Cited by 11 publications

References 9 publications

A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis

A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis

Generalized pustular psoriasis: a review and update on treatment

Generalized pustular psoriasis complicated with bullous pemphigoid

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