Anti-laminin 5 pemphigoid and acquired haemophilia

A, Ly; Roth, B.; As, Causeret; Jullien, D; Kanitakis, Jean; Faure, M; Claudy, A

doi:10.1046/j.1365-2133.2002.47323.x

Cited by 18 publications

(11 citation statements)

References 8 publications

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“…2 In another case, acquired haemophilia was associated with anti-laminin 5 pemphigoid, a rare autoimmune blistering disease. 4 Autoantibodies, such as PM-Scl have also been found to be associated with acquired haemophilia, 5 but in this case no such autoantibodies were detected.…”

Section: Discussionmentioning

confidence: 59%

Acquired haemophilia heralded by bleeding into the oral mucosa in a patient with bullous pemphigoid, rheumatoid arthritis, and vitiligo

Patel

Harman

Nichols

et al. 2006

Postgraduate Medical Journal

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Acquired haemophilia is rare and potentially fatal, with a mortality of 20% if left untreated. There is a strong association with other autoimmune diseases. This report describes a patient with rheumatoid arthritis, vitiligo, and bullous pemphigoid where the diagnosis of acquired haemophilia was made after an extensive bleed into a bullous lesion in the buccal mucosa. This case highlights some of the potential complications of acquired haemophilia and its treatment.

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Section: Discussionmentioning

confidence: 59%

Acquired haemophilia heralded by bleeding into the oral mucosa in a patient with bullous pemphigoid, rheumatoid arthritis, and vitiligo

Patel

Harman

Nichols

et al. 2006

Postgraduate Medical Journal

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“…An association with autoimmune bullous dermatoses has been described in bullous pemphigoid, pemphigus vulgaris and linear IgA disease, but only one previous report of PF co‐existing with acquired haemophilia has been described . The features of reports associated with pemphigus subtypes are demonstrated in (Table ).…”

Section: Characteristics Of Patients In the Literature And The Currenmentioning

confidence: 99%

Pemphigus foliaceus and acquired haemophilia: a rare but important association with life-threatening consequences

et al. 2018

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“…2,6,7,19,25,26,29,30 Reported cases of autoimmune bullous dermatoses associated with AH include pemphigus vulgaris, [31][32][33] pemphigus erythematosus, 34 bullous pemphigoid, [35][36][37][38][39][40][41][42][43][44] epidermolysis bullosa acquisita [45][46][47] and anti-laminin 5 pemphigoid. 48 However, to the best of our knowledge, there have not been any previous reports of LABD associated with AH, so the present report may be the first case of LABD associated with AH. In our patient, AH showed its typical characteristics: elongation of APTT, decrease of factor VIII activities, existence of factor VIII inhibitors and increase of creatine phosphokinase, as well as widespread ecchymoses in the skin and a hematoma in the retroperitoneal space revealed by CT.…”

Section: Discussionmentioning

confidence: 56%

Case of linear immunoglobulin A bullous dermatosis associated with acquired hemophilia

Arakaki

Yamamoto

Awazawa

et al. 2008

The Journal of Dermatology

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Linear immunoglobulin (Ig)A bullous dermatosis is a rare autoimmune subepidermal bullous dermatosis caused by circulating IgA autoantibodies directed against the antigens at the basement membrane zone. Most linear IgA bullous dermatosis cases are idiopathic, but some are associated with the use of certain drugs, infections, lymphoproliferative disorders, internal malignancies, autoimmune disorders, collagen diseases or, very rarely, other skin diseases, including autoimmune bullous diseases. Acquired hemophilia is also rare; it is a coagulation disease caused by anti-factor VIII IgG antibodies. Acquired hemophilia has been reported to be associated with malignant tumors, pregnancy or postpartum, drug reactions, collagen diseases such as rheumatoid arthritis, autoimmune disorders, and skin diseases such as psoriasis and pemphigus. We report a case of hemophilia acquired during the course of linear IgA bullous dermatosis and review reported cases of autoimmune bullous dermatoses associated with acquired hemophilia.

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Anti-laminin 5 pemphigoid and acquired haemophilia

Cited by 18 publications

References 8 publications

Acquired haemophilia heralded by bleeding into the oral mucosa in a patient with bullous pemphigoid, rheumatoid arthritis, and vitiligo

Acquired haemophilia heralded by bleeding into the oral mucosa in a patient with bullous pemphigoid, rheumatoid arthritis, and vitiligo

Pemphigus foliaceus and acquired haemophilia: a rare but important association with life-threatening consequences

Case of linear immunoglobulin A bullous dermatosis associated with acquired hemophilia

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