Anti‐Jk<sup>a</sup> that are detected by solid‐phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions

Kay, Brian H.; Poisson, Jessica; Tuma, Christopher W.; Shulman, Ira A.

doi:10.1111/trf.13782

Cited by 21 publications

(16 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yamada and colleagues and Garozzo and colleagues noted solid‐phase techniques to be more sensitive for the detection of antibodies in the Rh system, supporting the notion that some UID reactivity can be due to the increased sensitivity of the test and not false reactivity . Anecdotally, we also see more anti‐Jk identified using solid phase, an observation that has recently been supported by both others and our own findings that no new Jk alloantibodies were detected in solid phase after a UID, but were observed using t‐PEG during our study interval.…”

Section: Discussionsupporting

confidence: 88%

Patient factors associated with unidentified reactivity in solid‐phase and polyethylene glycol antibody detection methods

et al. 2017

View full text Add to dashboard Cite

When solid phase is used for antibody identification, there is greater sensitivity toward nonspecific reactivity when compared to the t-PEG method. Patient sex and underlying diagnosis may explain the increased incidence of new UID reactivity in the solid-phase technology. Finally, UID reactivity should not be overlooked due to a notable percentage of subsequent clinically significant antibodies after UID detection.

show abstract

Section: Discussionsupporting

confidence: 88%

Patient factors associated with unidentified reactivity in solid‐phase and polyethylene glycol antibody detection methods

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Anti‐Kidd antibodies are well known for transient detectability and for their involvement in haemolytic transfusion reactions. Once anti‐Jk a is formed, the antibody frequently diminishes in strength so that standard antibody screening methods fail to detect it (Kay, Poisson, Tuma, & Shulman, ). Thus, these antibodies are dangerous as a cause of clinically significant delayed haemolytic transfusion reaction (DHTRs) (Heddle et al, ).…”

Section: Discussionmentioning

confidence: 99%

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Romphruk

Butryojantho

Jirasakonpat

et al. 2019

Int J Immunogenetics

View full text Add to dashboard Cite

We here report the first study of antigen and phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd antigens in north‐east Thai blood donors. Blood transfusion services aim to ensure availability of adequate and safe blood to minimize the development of transfusion reactions. For pre‐transfusion testing, the most important blood group systems are ABO and RhD. The transfusion of ABO‐compatible otherwise unknown phenotype blood may result in alloimmunization, especially in multi‐transfused patients. Extended red blood cell (RBC) phenotyping and selection of blood negative for specific antigens reduce post‐transfusion complications and allow for effective blood transfusion regimens to be achieved. A total of 13,567 regular repeated, voluntary Thai blood donors were included for red‐cell antigen typing of Rh (D, C, E, c, e). Samples from 12,768, 9,389 and 13,059 donors were typed for Kidd, M and Mia antigens, respectively. Amongst Rh antigens, e was the most common (96.80%) followed by C (95.50%), c (34.40%) and E (32.20%) with CCDee (60.00%) being the most common phenotype. For Kidd phenotypes, Jk(a+b+) was the most common (46.73%) and Jk(a−b−) was rare (0.07%). For the M and Mia antigen, M(+) was most frequently found (94.96%) and Mia(+) was found in 17.97% of individuals. Knowledge of red‐cell antigen phenotype frequencies in a population is helpful for creating a phenotype database of blood donors which can provide antigen‐negative compatible blood to patients with multiple alloantibodies. Moreover, provision of antigen‐matched blood can prevent alloimmunization in multi‐transfused patients.

show abstract

“…[ 2 3 4 ] The autoantibody to Kidd blood groups has also been reported. [ 5 ] The present case with naturally occurring IgG alloantibody was found in a nontransfused healthy male. It was detected by the solid-phase automated serology device but not by the manual tube technique on antibody screening test (AST) was unique in nature for investigation.…”

Section: Introductionmentioning

confidence: 85%

A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method

Kanani¹,

Senjaliya²,

Rajapara³

et al. 2020

Asian J Transfus Sci

View full text Add to dashboard Cite

BACKGROUND: Antibodies to the Kidd blood group are mainly red blood cell (RBC) immune, but a few reports on naturally occurring antibodies have been documented. AIM: The aim of this study is to study the anti-Jk(a) for its unusual reactivity with different serological methods. MATERIALS AND METHODS: Donor's plasma was tested with RBCs from in house donors and commercial panels by manual and automated devices. RESULTS: A 36-year-old male blood donor with naturally occurring anti-Jk(a) is detected by solid-phase assays and the gel card technique but not by the tube method. The IgG antibody with the titer of >32 was not a complement-fixing hemolysin, showed a reduced reactivity with enzyme-treated RBCs, and was detectable through 8 months' follow-up period. The donor was typed as (Jk(a−). CONCLUSION: An unusual naturally occurring anti-Jk(a) detected by solid-phase red-cell adherence but not reacting by tube technique reflected on the sensitivity of the methods used.

show abstract

Anti‐Jk^a that are detected by solid‐phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions

Abstract: SPRCA testing significantly increased the discovery of clinically significant anti-Jk and facilitated the earlier use of Jk(a-) RBCs to avoid hemolytic transfusion reactions.

Cited by 21 publications

References 13 publications

Patient factors associated with unidentified reactivity in solid‐phase and polyethylene glycol antibody detection methods

Patient factors associated with unidentified reactivity in solid‐phase and polyethylene glycol antibody detection methods

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method

Contact Info

Product

Resources

About

Anti‐Jka that are detected by solid‐phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions

Abstract: SPRCA testing significantly increased the discovery of clinically significant anti-Jk and facilitated the earlier use of Jk(a-) RBCs to avoid hemolytic transfusion reactions.

Cited by 21 publications

References 13 publications

Patient factors associated with unidentified reactivity in solid‐phase and polyethylene glycol antibody detection methods

Patient factors associated with unidentified reactivity in solid‐phase and polyethylene glycol antibody detection methods

Phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method

Contact Info

Product

Resources

About

Anti‐Jk^a that are detected by solid‐phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand