Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction

Цорин, И. Б.; Барчуков, В. В.; Вититнова, М. Б.; Крыжановский, С. А.; Seredenin, S. B.

doi:10.1007/s10517-019-04586-x

Cited by 4 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Известно положительное влияние препарата на соотношение индуцибельной и эндотелиальной NO-синтаз. При этом фабоматизол, тормозя деятельность индуцибельной NO-синтазы (NOS-2), повышает функциональную активность эндотелиальной NO-синтазы (eNOS) [13]. Вышеизложенное послужило основанием для проведения данного исследования.…”

Section: результаты и обсуждениеunclassified

Effects of fabomatisol under lead intoxication in rat experiment

Dzugkoev,

Dzugkoeva,

Margieva

et al. 2023

SJCEM

View full text Add to dashboard Cite

The conducted study indicates the priority use of the drug fabomatizole to protect living systems from the negative effects of lead acetate.Aim: To study the mechanisms of fabomatizole effect on the nature of changes in redox reactions, NO-forming function of the endothelium, cholesterol metabolism and functional parameters in rats with lead intoxication.Material and Methods. The study was carried out on 60 Wistar rats. Lead intoxication was induced by intramuscular administration of lead acetate at a dose of 5 mg/kg of animal weight for a month. At the end of the intoxication period, Fabomatizol was administered at a dose of 10 mg/kg for a month. Next, blood and tissue samples were taken from rats to determine the activity of oxidative, antioxidant, enzymatic systems, nitric oxide metabolism, and blood lipid spectrum.Results. The data obtained showed that intramuscular administration of fabomatisol in case of lead intoxication has an antioxidant effect and inhibits lipid peroxidation (LPO) activity. Under the influence of fabomatizol, nitric oxide metabolism andtotal nitric oxide metabolites (NOx) content significantly increased, and a negative correlation was found between the malondialdehyde level, superoxide dismutase activity and NOx. At the same time, the study found a decrease in the expression level of eNOS as the cause of a reduced concentration of NOx in the blood. L-arginine availability for eNOS was disturbed by atherogenic low density lipoprotein (LDL). Treatment with fabomatizol against the background of lead intoxication caused a decrease in total cholesterol, LDL cholesterol and an increase inhigh density lipoprotein cholesterol. By inhibiting lipid peroxidation in the cells of the renal and hepatic tissues, fabomatizol contributed to the restoration of lipid-protein interactions and the functional activity of Na and K-activated ATPase in the renal interstitium. Simultaneously, there is an activation of Na,K-ATP-ase in the hepatocyte and a decrease in the level of organ-specific enzymes in the blood plasma.Conclusion. The results obtained are evidence of the antioxidant properties of fabomatisol in lead intoxication, its ability to induce the activity of antioxidant system (AOS enzymes, stimulate the NO-forming function of the endothelium, NOx production and the activity of the membrane enzyme – Na,K-ATP-ase in the renal and hepatic tissues and reduce the level of organ-specific enzymes in blood plasma.

show abstract

Section: результаты и обсуждениеunclassified

Effects of fabomatisol under lead intoxication in rat experiment

Dzugkoev,

Dzugkoeva,

Margieva

et al. 2023

SJCEM

View full text Add to dashboard Cite

show abstract

Application of gabapentinoids and novel compounds for the treatment of benzodiazepine dependence: the glutamatergic model

et al. 2022

View full text Add to dashboard Cite

The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium

Цорин

Simonenko

Вититнова

et al. 2022

Fk&Fd

View full text Add to dashboard Cite

The investigation purpose was to study the effect of fabomotizole on blood microcirculation in intact and ischemic myocardium in conditions of acute ischemia of the heart muscle. The experiments were carried out on anesthetized (urethane, 1300 mg/kg, i.p.) white mongrel male rats weighing 220–250 g. Acute myocardial ischemia was caused by occlusion of the left coronary artery. Blood microcirculation was evaluated by laser Doppler flowmetry using a computerized laser analyzer "LAKK-OP2". It was found that fabomotizole (15 mg/kg, i.v.) in an intact heart does not affect blood microcirculation. Immediately after coronary artery ligation in the myocardial ischemia zone, microcirculation decreases sharply (by about 30 %, p = 0.0106) and practically does not change in the conditionally intact myocardium. Fabomotizole, administered 5 minutes before occlusion of the coronary artery, prevented a decrease in microcirculation in the ischemiс zone of the myocardium. The ability of fabomotizole in conditions of acute myocardial ischemia to prevent a decrease in the level of microcirculation in the ischemic zone may contribute to the anti-ischemic activity of the drug.

show abstract

Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction

Cited by 4 publications

References 11 publications

Effects of fabomatisol under lead intoxication in rat experiment

Effects of fabomatisol under lead intoxication in rat experiment

Application of gabapentinoids and novel compounds for the treatment of benzodiazepine dependence: the glutamatergic model

The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium

Contact Info

Product

Resources

About