Anti‐interleukin‐8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease

Takasaki, Jiro; Ogawa, Yutaka

doi:10.1046/j.1442-200x.2001.01341.x

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…According to Fig. 1, whereas NF-B activation by isolated P. fluorescens LPS was transient (0.5 to 2 h), direct pathogen-augmented IL-8 mRNA and NF-B activation continues to increase for up to 24 h. Released C-X-C chemokine IL-8 is a potent chemoattractant for neutrophils and has been implicated in a number of respiratory ailments, including respiratory distress syndrome, chronic obstructive pulmonary disease, and asthma (9,30,31). There could be several explanations for the extended activation of NF-B in response to P. fluorescens infection.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Epidermal Growth Factor Receptor-Linked Signaling Responses in Pseudomonas fluorescens-Infected Alveolar Epithelial Cells

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Involvement of Epidermal Growth Factor Receptor-Linked Signaling Responses in Pseudomonas fluorescens-Infected Alveolar Epithelial Cells

et al. 2011

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“…Therefore, they seem to be a physiologic mechanism used to control the immune response [ 22 ]. In contrast, pathogenic anti-cytokine aAbs, which are usually polyclonal IgGs, may affect cytokine biology through diminishing or augmenting signaling or altering their half-lives in the circulation [ 22 , 38 , 40 , 41 , 42 , 43 ]. Anti-cytokines aAbs were found in patients with SLE, Sjogren’s syndrome, and rheumatoid arthritis [ 43 ].…”

Section: Production Of Aabsmentioning

confidence: 99%

Autoantibodies to Interferons in Infectious Diseases

Quiros-Roldan

Sottini

Signorini

et al. 2023

Viruses

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Anti-cytokine autoantibodies and, in particular, anti-type I interferons are increasingly described in association with immunodeficient, autoimmune, and immune-dysregulated conditions. Their presence in otherwise healthy individuals may result in a phenotype characterized by a predisposition to infections with several agents. For instance, anti-type I interferon autoantibodies are implicated in Coronavirus Disease 19 (COVID-19) pathogenesis and found preferentially in patients with critical disease. However, autoantibodies were also described in the serum of patients with viral, bacterial, and fungal infections not associated with COVID-19. In this review, we provide an overview of anti-cytokine autoantibodies identified to date and their clinical associations; we also discuss whether they can act as enemies or friends, i.e., are capable of acting in a beneficial or harmful way, and if they may be linked to gender or immunosenescence. Understanding the mechanisms underlying the production of autoantibodies could improve the approach to treating some infections, focusing not only on pathogens, but also on the possibility of a low degree of autoimmunity in patients.

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“…[6][7][8][9][10] Expression of individual inflammatory mediators in tracheobronchial aspirate fluid or in bronchoalveolar lavage from preterm infants has been described. [11][12][13][14][15] In addition, the nitrite/nitrate levels are higher in newborns with RDS; in fact, there is now good evidence that enhanced formation of NO synthase plays an important role in asphyxia, shock, and inflammation. 16 Melatonin is a newly discovered and endogenously produced antioxidant that has broad-spectrum antioxidative functions.…”

mentioning

confidence: 99%

Oxidative and Inflammatory Parameters in Respiratory Distress Syndrome of Preterm Newborns: Beneficial Effects of Melatonin

Reíter²,

et al. 2004

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Reactive oxygen species play an important role in the pathogenesis of respiratory distress syndrome and its complications. This study was conducted to determine if treatment with the antioxidant melatonin would influence interleukin-6, interleukin-8, tumor necrosis factor alpha, and nitrite/nitrate levels in newborns with grade III or IV respiratory distress syndrome (radiographically confirmed) diagnosed within the first 6 hours of life. Prior to treatment, a blood sample was collected from the umbilical cord or a peripheral vein of each newborn. Second, third, and fourth blood samples were collected at 24 hours, 72 hours, and 7 days, respectively, after beginning treatment with melatonin or placebo. Compared with the melatonin-treated respiratory distress syndrome newborns, in the untreated infants the concentrations of interleukin-6, interleukin-8, and tumor necrosis factor alpha were significantly higher at 24 hours, 72 hours, and at 7 days after onset of the study. in addition, nitrite/nitrate levels at all time points were higher in the untreated respiratory distress syndrome newborns than in the melatonin-treated babies. Following melatonin administration, nitrite/nitrate levels decreased significantly, whereas they remained high and increased further in the respiratory distress syndrome infants not given melatonin.

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Anti‐interleukin‐8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease

Cited by 8 publications

References 16 publications

Involvement of Epidermal Growth Factor Receptor-Linked Signaling Responses in Pseudomonas fluorescens-Infected Alveolar Epithelial Cells

Involvement of Epidermal Growth Factor Receptor-Linked Signaling Responses in Pseudomonas fluorescens-Infected Alveolar Epithelial Cells

Autoantibodies to Interferons in Infectious Diseases

Oxidative and Inflammatory Parameters in Respiratory Distress Syndrome of Preterm Newborns: Beneficial Effects of Melatonin

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