Anti-influenza A virus activity by Agrimonia pilosa and Galla rhois extract mixture

Pistacia vera L. as natural source against antimicrobial and antiviral resistance

“…The therapeutic potential of apigenin against viral infection has recently been reviewed by Lee et al (2023) . Apigenin exerts virucidal activity against HSV-1 interfering with viral absorption and inhibiting the post-entry step of the viral replication ( Lyu et al, 2005 ; Yucharoen, 2011 ; Visintini Jaime et al, 2013 ; Fahmy et al, 2020 ; Rittà et al, 2020 ), against Enterovirus 71 by inhibiting the interaction between internal ribosome entry site of EV71 and hnRNP A1 and A2 ( Shih et al, 2011 ; Lv et al, 2014 ; Zhang et al, 2014 ; Ji et al, 2015 ; Dai et al, 2019 ), against hepatitis C virus by binding to NS5B and inhibiting RdRp activity, decreasing miR122 expression levels and suppressing the phosphorylation of TRBP ( Manvar et al, 2012 ; Ohno et al, 2013 ; Pisonero-Vaquero et al, 2014 ; Shibata et al, 2014 ), against Dengue virus by restoring STAT2 Tyr 689 phosphorylation and activation, colocalization with a DENV protein in the early phase of infection ( Mazzon et al, 2009 ; Jasso-Miranda et al, 2019 ; Acchioni et al, 2023 ), against SARS-CoV by reducing the production of proinflammatory cytokine in response to viral infection, as well as interacting with viral protein (Mpro) and host factor (ACE-2 receptor, TMPRSS2) ( Ryu et al, 2010 ; Jo et al, 2020 ; Zhang et al, 2020 ; Alzaabi et al, 2022 ; Chaves et al, 2022 ; Farhat et al, 2022 ) as well as against influenza virus - by neuroaminidase inhibition, viral attachment and entry inhibition, inhibition of viral mRNA expression, inhibition of influenza A virus RdRP activity, reduction of viral particle production, and nucleoprotein reduction ( Liu et al, 2008 ; Kai et al, 2014 ; Xu et al, 2020a , 2020b ; Joo et al, 2022 ; Morimoto et al, 2023 ).…”

Anti-Inflammatory Effects of Alphitolic Acid Isolated from Agrimonia coreana Nakai Extracts Are Mediated via the Inhibition of ICRAC Activity in T Cells

“…Moreover, it is used in traditional Chinese medicine for hemostatic, anti-malarial, detoxifying, and anti-tumor effects [20,21]. However, other medicinal effects of A. coreana are being investigated, with reports on anti-oxidant, anti-inflammatory, and anti-viral properties [22][23][24][25]. Furthermore, A. coreana contains myriad active compounds from flavonoids to triterpenes and their glycosides, isoflavones, isocoumarins, phloroglucinol derivatives, tannins, and organic acids, comprising 252 constituents, with numerous associated ongoing studies [20].…”