Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

Yodoi, Junji; Matsuo, Yoshiyuki; Tian, Hai; Masutani, Hiroshi; Inamoto, Takashi

doi:10.3390/nu9101081

Cited by 26 publications

(24 citation statements)

References 106 publications

(113 reference statements)

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“…Thereby, the dysregulation of Trx system considers as a crucial mechanism to cause endothelium and heart tissue damage post‐irradiation. This is in concordance with the previous study in which exposure to ultraviolet‐A radiation might increase ROS that could potentially decrease the activity of Trx associated with enhanced expression of TXNIP protein …”

Section: Discussionsupporting

confidence: 93%

Impact of zinc oxide nanoparticles on thioredoxin‐interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma‐irradiated rats

Abdel‐Magied

Shedid

2019

Environmental Toxicology

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Nanoparticle is a microscopic particle that has been existed in a wide range of biotechnological purposes. Zinc oxide nanoparticles (ZnO‐NPs) have fewer environmental hazards and have shown positive impacts in the medical field. This work aimed to observe the effects of low and high doses of ZnO‐NPs on heart injury induced by ionizing radiation (IR). Animals were irradiated by 8 Gy of gamma rays and ZnO‐NPs (10 and 300 mg/Kg/day) were orally delivered to rats 1 hour after irradiation. Animals were dissected on 15th day postirradiation. Data showed that the oxidative damage resulted from radiation exposure, appeared by marked increments in the malondialdehyde (MDA) content and the level and protein expression of thioredoxin‐interacting protein (TXNIP) with a noticeable decline in the level and expression of thioredoxin 1 (Trx‐1) and thioredoxin reductase (TrxR), as well as glutathione (GSH) level and the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Moreover, radiation‐induced inflammation, manifested by a noticeable elevation in the level of tumor necrotic factor‐alpha (TNF‐α), interleukin‐18 (IL‐18), and C‐reactive protein (CRP). Additionally, endothelial dysfunction marked with a high level of asymmetric dimethylarginine (ADMA), total nitrite/nitrate (NOx), intercellular adhesion molecule 1 (ICAM‐1), homocysteine (Hcy), creatine kinase (CK‐MB), cardiac troponin‐I (cTn‐I), and lactate dehydrogenase (LDH). In addition, a decrease of zinc (Zn) level in the cardiac tissue was recorded. ZnO‐NPs treatment (10 mg/kg) mitigated the oxidative stress and inflammation effects on the cardiovascular tissue through the positive modulations in the studied parameters. In contrast, ZnO‐NPs treatment (300 mg/kg) induced cardiovascular toxicity of normal rats and elevated the deleterious effects of radiation. In conclusion, ZnO‐NPs at a low dose could mitigate the adverse effects on cardiovascular tissue induced by radiation during its applications, while the high dose showed morbidity and mortality in normal and irradiated rats.

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Section: Discussionsupporting

confidence: 93%

Impact of zinc oxide nanoparticles on thioredoxin‐interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma‐irradiated rats

Abdel‐Magied

Shedid

2019

Environmental Toxicology

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“…Trx-1 is involved in various redox reactions, and its reversible oxidation of the active center catalyzes the dithioldisulfide exchange reaction. 40 As an auxiliary factor of intracellular antioxidant and reductant, Trx-1 is widely involved in several functions of cells including protein disulfifide reduction, oxidative stress regulation and regulation of transcription factor. [41][42][43] Our previous study has shown that Trx-1 has an important role in CRC and the elevation of Trx-1 promoted cancer invasion and metastasis by promoting the EMT in CRC.…”

Section: Discussionmentioning

confidence: 99%

<p>Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1</p>

Wang¹,

Fang²,

Zhang³

et al. 2020

OTT

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Background: Sodium butyrate (NaB) is a short-chain fatty acid which is produced by bacterial fermentation of nondigestible dietary fiber and has been reported to exert anti-tumor effects in many tumors including colorectal cancer (CRC). However, the role of thioredoxin-1 (Trx-1) in NaB-induced anti-tumor effect has not been completely clarified. Materials and Methods: Effects of NaB on the growth of CRC cell lines HT29 and SW480 were detected by the Cell Counting Kit-8 (CCK-8) and colony formation assays. The apoptotic cells were determined by flow cytometry, and cell migration was assessed by a Transwell assay. Western blot analysis was used to test the Trx-1 and epithelial-to-mesenchymal transition (EMT)-related proteins level. Reactive oxygen species (ROS) level was determined and N-acetylcysteine (NAC) recovery experiment was performed in CRC cells. In addition, mice xenograft model was established to test the effect of NaB on CRC growth in vivo. Further, the effects of NaB on CRC cells with overexpression or knockdown were tested by the CCK-8 and Transwell assays. Results: NaB treatment significantly inhibited cell growth and decreased Trx-1 protein expression in CRC cells but not in normal colon epithelial cells. NaB also induced apoptosis, inhibited colony formation, migration and EMT in CRC cells. Besides, NaB increased ROS level in CRC cells and NAC reversed NaB-induced inhibition of cell proliferation. Moreover, downregulation of Trx-1 significantly enhanced NaB-induced inhibitory effects on cell growth and migration, whereas overexpression of Trx-1 attenuated NaB-induced inhibitory effects on growth and migration in CRC cells. Conclusion: These findings indicate that the NaB-mediated anti-tumor effects on CRC cells are related to downregulation of Trx-1.

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“…266 This signalling complex may be a key regulatory mechanism for the body to regulate cellular redox balance and prevent the progression or exacerbation of stressinduced diseases. 268 Regulating the protease balance Both endogenous and exogenous Trx inhibit and improve a protease-induced emphysema. 269 MMP-9 and MMP-2 play important roles in COPD.…”

Section: Trx and Its Effect In Copdmentioning

confidence: 99%

Progress in the mechanism and targeted drug therapy for COPD

Wang

Zhou

Wang

et al. 2020

Sig Transduct Target Ther

Self Cite

125

117

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Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor airflow. The prevalence of COPD has increased over the last decade and the drugs most commonly used to treat it, such as glucocorticoids and bronchodilators, have significant therapeutic effects; however, they also cause side effects, including infection and immunosuppression. Here we reviewed the pathogenesis and progression of COPD and elaborated on the effects and mechanisms of newly developed molecular targeted COPD therapeutic drugs. Among these new drugs, we focussed on thioredoxin (Trx). Trx effectively prevents the progression of COPD by regulating redox status and protease/anti-protease balance, blocking the NF-κB and MAPK signalling pathways, suppressing the activation and migration of inflammatory cells and the production of cytokines, inhibiting the synthesis and the activation of adhesion factors and growth factors, and controlling the cAMP-PKA and PI3K/Akt signalling pathways. The mechanism by which Trx affects COPD is different from glucocorticoid-based mechanisms which regulate the inflammatory reaction in association with suppressing immune responses. In addition, Trx also improves the insensitivity of COPD to steroids by inhibiting the production and internalisation of macrophage migration inhibitory factor (MIF). Taken together, these findings suggest that Trx may be the ideal drug for treating COPD.

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Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

Cited by 26 publications

References 106 publications

Impact of zinc oxide nanoparticles on thioredoxin‐interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma‐irradiated rats

Impact of zinc oxide nanoparticles on thioredoxin‐interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma‐irradiated rats

<p>Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1</p>

Progress in the mechanism and targeted drug therapy for COPD

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