Anti-inflammatory terpenes from Schefflera rubriflora C. J. Tseng &amp; G. Hoo with their TNF-α and IL-6 inhibitory activities

Li, Fenghua; Zhang, Jian; Lin, Mingbao; Su, Xiuqin; Li, Changkang; Wang, Hongqing; Li, Baoming; Chen, Ruo-Yun; Kang, Jie

doi:10.1016/j.phytochem.2019.03.021

Cited by 23 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The general effect of the terpenes in most studies is reducing the pro-inflammatory cytokines expression. For example, some terpenes (D-Limonene, α-Phellandrene, Terpinolene, Borneol, Linalool, and triterpene glycosides) can reduce the expression of TNF-α, IL-1, and IL-6 in the Raw 264.7 macrophages cell line (Yoon et al, 2010;Huo et al, 2013;de Christo Scherer et al, 2019;Li et al, 2019). Similar results were obtained in experiments using in vivo models such as swiss mice, Wistar rats, and albino mice (BALB/C) (Ramalho et al, 2015;Li et al, 2016;Gonçalves et al, 2020).…”

Section: Effect Of Terpenes In Pro-inflammatory Moleculessupporting

confidence: 73%

Therapeutic Applications of Terpenes on Inflammatory Diseases

et al. 2021

View full text Add to dashboard Cite

In the last decades, the search for natural products with biological applications as alternative treatments for several inflammatory diseases has increased. In this respect, terpenes are a family of organic compounds obtained mainly from plants and trees, such as tea, cannabis, thyme, and citrus fruits like lemon or mandarin. These molecules present attractive biological properties such as analgesic and anticonvulsant activities. Furthermore, several studies have demonstrated that certain terpenes could reduce inflammation symptoms by decreasing the release of pro-inflammatory cytokines for example, the nuclear transcription factor-kappa B, interleukin 1, and the tumor necrosis factor-alpha. Thus, due to various anti-inflammatory drugs provoking side effects, the search and analysis of novel therapeutics treatments are attractive. In this review, the analysis of terpenes’ chemical structure and their mechanisms in anti-inflammatory functions are addressed. Additionally, we present a general analysis of recent investigations about their applications as an alternative treatment for inflammatory diseases. Furthermore, we focus on terpenes-based nanoformulations and employed dosages to offer a global perspective of the state-of-the-art.

show abstract

Section: Effect Of Terpenes In Pro-inflammatory Moleculessupporting

confidence: 73%

Therapeutic Applications of Terpenes on Inflammatory Diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…O. Berg, followed by compounds classified as organic acids and alcohols [ 12 ]. It is known that the essential jabuticaba oil contains terpenes, such as α-pinene, β-pinene, 1,8-cineole, α-terpineol, and β-caryophyllene, known for their antibacterial and anti-inflammatory actions, suggesting that the same volatile compounds present in the fruit aroma are indicative of endogenous levels and potential bioactive action [ 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Volatile Compounds and Physicochemical Quality of Four Jabuticabas (Plinia sp.)

et al. 2020

View full text Add to dashboard Cite

The jabuticaba is a native Brazilian fruit that has aroused worldwide interest in terms of its nutritional composition and biological activity. However, research on the profile of volatile compounds (VOCs) emitted by these fruits is rare. This study presents the first identification of VOCs from four jabuticaba species. The aim of the study was to characterize the aromatic profile of the following species: ‘Sabará’ (Plinia jaboticaba), ‘Escarlate’ (Plinia phitrantha × Plinia cauliflora), ‘Otto Andersen’ (Plinia cauliflora), and ‘Esalq’ (Plinia phitrantha). The analysis was performed by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry (SPME-GC-MS). Multivariate analysis techniques applying the partial least squares-discriminant analysis (PLS-DA) and heatmap were used to compare the results. Fruit quality parameters were determined in terms of fresh mass (g), skin color, soluble solids, and titratable acidity. A total of 117 VOCs was identified including terpenoids, esters, alcohols, aldehydes, alkanes, ketones, and carboxylic acids, with 36 VOCs common to all four species. Terpenes were the majority for all jabuticabas with smaller contributions from other volatile classes, especially β-cubebene, β-elemene, and D-limonene for the ‘Otto Andersen’ jabuticaba.

show abstract

“…Plant terpenes have been shown to exhibit potential anti-in ammatory and antioxidant activity (González-Burgos et al, 2012; Vega et al, 2018;Li et al, 2019). In this study, the observation that TRDF and TREF ameliorated LPS-induced production of in ammatory cytokines and restored antioxidant enzyme activity may be attributed to the anti-in ammatory and antioxidant activities of the terpenes present in the fractions.…”

Section: Discussionmentioning

confidence: 56%

Terpene-rich fractions of Ficus mucoso (Welw) modulate lipopolysaccharide-induced inflammatory mediators and aberrant permeability of the inner mitochondrial membrane in murine animal model

et al. 2021

View full text Add to dashboard Cite

Ficus mucoso is traditionally used to treat various infections. This study compared the e cacy of terpene-rich fractions of F. mucoso root bark on LPS-induced in ammation, liver mitochondrial permeability transition (mPT) pore, an index of mitochondrial health, and associated pathological alterations. Terpene-Rich fractions of Dichloromethane (TRDF) and Ethylacetate fractions of F. mucoso (TREF) were obtained according to the method described by Ferguson (1956). A single intraperitoneal injection of 1 mg/kg lipopolysaccharide (LPS) were given to mice to induce systemic in ammation for 72hrs. Evaluation of the effects of the TRDF and TREF on levels of pro-in ammatory mediators (TNF-α, IL-1β, IL-6) and antioxidant indices against LPS-induced hepatic damage were carried out. Mitochondrial swelling was monitored spectrophotometrically as well as mitochondrial ATPase activity and lipid peroxidation.This study reveals that TRDF and TREF possess anti-in ammatory potentials which is related to reduction in levels of pro-in ammatory cytokines, restoration of antioxidant status, reduction in levels of liver marker enzymes as well as associated pathological injury. Furthermore, LPS caused induction of opening of the liver mPT pore which was signi cantly inhibited by TRDF at 100 and 200 mg/kg bw by 71% and 88% respectively, but only at 100 mg/kg TREF. Furthermore, mitochondrial ATPase activity was inhibited largely by TRDF. The UPLC-ESI-MS analysis revealed the presence of terpenoid derivatives and a few aromatic metabolites in TRDF. The terpene dominance of TRDF metabolites was further justi ed on the 1 H NMR ngerprint.Overall, TRDF is more effective as a cocktail of anti-in ammatory compounds than TREF against LPSinduced acute systemic in ammation.

show abstract

Anti-inflammatory terpenes from Schefflera rubriflora C. J. Tseng & G. Hoo with their TNF-α and IL-6 inhibitory activities

Cited by 23 publications

References 26 publications

Therapeutic Applications of Terpenes on Inflammatory Diseases

Therapeutic Applications of Terpenes on Inflammatory Diseases

Volatile Compounds and Physicochemical Quality of Four Jabuticabas (Plinia sp.)

Terpene-rich fractions of Ficus mucoso (Welw) modulate lipopolysaccharide-induced inflammatory mediators and aberrant permeability of the inner mitochondrial membrane in murine animal model

Contact Info

Product

Resources

About