Anti-inflammatory Study on the Constituents of <i>Angelica sinensis</i> (Oliv.) Diels, <i>Angelica dahurica</i> (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., <i>Angelica pubescence</i> Maxim and <i>Foeniculum vulgare</i> Mill. Essential Oils

Abstract

tion of human body 3) . With the development of modern medicine, the mechanism of partial inflammation has been preliminarily speculated 4) . It seriously affected people s normal life because of its characteristics of strong suddenness, long duration and repeated attacks 5) . While synthetic drugs are available to fight inflammation effectively, the Abstract: Umbelliferae plants, which are widely used as traditional Chinese medicine because of their characteristics of relieving rheumatism, alleviating fever, circulating blood and easing pain. This experimental study was based on ear edema model caused by 12-O-tetracycline-propylphenol-13-acetic acid (TPA) in mice and compared with the Ibuprofen (Ib) group. Gas chromatography-mass spectrometry (GC-MS) was used to analyse the composition of the essential oils from the four studied Umbelliferae plants (Angelica sinensis (Oliv.) Diels, A. dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., A. pubescens Maxim and Foeniculum vulgare Mill.). Biologically active components in volatile oils from the four studied Umbelliferae plants were evaluated. The expression levels of inflammatory cytokines Tumor Necrosis Factor-α (TNF-α), Cyclooxygenase-2 (COX-2), Interleukin-6 (IL-6) and RelA (p65) in mouse skin were determined by immunohistochemical method. The refractive index of the four essential oils was calculated. A total of 239 compounds were identified by GC-MS from the four studied plants, and the main constituents were osthole (44.61%, APEOs), obepin (0.59%, APEOs & 86.58%, FVEOs), undecanol (8.58%, ADEOs), αmuurolene (7.95%, ADEOs) and cis-anethol (9.11%, ADEOs). E-ligustilide (0.14%, APEOs & 81.14%, ASEOs), (-)-spathulenol (0.08%, FVEOs & 1.21%, ASEOs), (-)-terpinen-4-ol (4.91%, FVEOs), 2-butylthiolane (5.76%, APEOs) and α-bisabolol (3.80%, APEOs). This study showed that all the essential oils from the four studied Umbelliferae plants contained various lactones, including ligustrongolactone, trans-anisol and imperatorin. According to the results of the TPA induction test in the mouse ear edema model, the essential oils of four Umbelliferae plants reduced the levels of inflammatory cytokines TNF-α, COX-2, IL-6 and p65. All of them showed extraordinary biological activity in anti-inflammatory, so they have potential application value for biomedical products, pharmaceutical preparations, natural functional nutrients and cosmetic additives.

Essential Oils from Mediterranean Plants Inhibit In Vitro Monocyte Adhesion to Endothelial Cells from Umbilical Cords of Females with Gestational Diabetes Mellitus

“…Nevertheless, several cellular studies have reported the capability of other EOs in alleviating inflammation [ 19 , 20 , 56 , 65 , 75 ], but to the best of our knowledge, this is the first report demonstrating the anti-inflammatory role of AEO and LEO in a GDM-HUVEC in vitro model.…”

“…Much evidence from in vitro and animal studies proves that EOs have multiple biological activities, such as anticancer [ 4 , 5 ], antiviral [ 6 , 7 , 8 , 9 ], antibacterial [ 10 , 11 , 12 , 13 ], antifungal [ 14 , 15 ], antibiofilm [ 16 , 17 , 18 ], anti-inflammatory [ 19 , 20 , 21 ], and antioxidant [ 19 , 22 , 23 , 24 , 25 ] effects, which constitute the starting point for the in vivo assessment of those properties in various therapeutic and cosmetic fields [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Nevertheless, since great consideration has been given to the effective use of EOs in clinical procedures, further systematic animal studies and clinical investigations are needed.…”

Chemical profiling and arginine kinase inhibitory activity of Angelica dahurica leaves

“…The volatile oils of A. dahurica roots showed bioactivities such as anti-inflammation [ 13 , 14 ] and antioxidation [ 15 , 16 ]. According to literatures, the volatile oil extracted from the root of A. dahurica were mainly alkenes [ 17 ].…”

Potential analgesic effect of Foshousan oil-loaded chitosan-alginate nanoparticles on the treatment of migraine

“…Radix Angelica Sinensis and Chuanxiong Rhizoma as major herbal ingredients of the FSS formula possessed blood nourishment, wind elimination, and pain alleviation in TCM perspectives ( Huang et al, 2020 ). Furthermore, modern medical studies reported that these two Chinese medicines had anti-nociceptive and anti-inflammatory activities ( Wang et al, 2020 ; Li C. et al, 2022 ). Tetramethylpyrazine (ligustrazine) from Chuanxiong Rhizoma showed an anti-inflammatory effect on cells by regulating related signaling pathways such as nuclear factor kappa-B (NF-κB) and PI3K/AKT ( Zheng et al, 2013 ; Zhang et al, 2020 ; Huang et al, 2021 ).…”