Anti-inflammatory studies on Adenanthera pavonina seed extract

Abstract

A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At doses of 100 and 200 mg/kg, pleurisy induced with carrageenan was also inhibited. The extract (50-200 mg/kg) exhibited a dose-dependent and significant (P < 0.05) analgesic activity in the acetic-induced writhing in mice. In addition, both early and late phases of the formalin-induced paw licking in mice was inhibited by the extract. Acute toxicity studies revealed that the extract produced reduced motor activity. The LD50 value of the extract was found to be 1.36 g/kg. This study demonstrated the anti-inflammatory and analgesic effects of A. pavonina extract.

Effect of processing methods on the nutritional values and anti-nutritive factors of Adenanthera pavonina L. (Fabaceae) seeds

“…It is endemic to India and Southeast China, where it is considered as an alternative nutrients source for animals and humans, but has been introduced into tropical and sub-tropical areas of the world including Malaysia, Polynesia and eastern and West Africa. The plant is known as "food tree" because its seeds and leaves are valued for food, and the seeds, which when roasted are said to taste like soy bean, possess high percentage of proteins, fatty acids, minerals and other nourishing properties (Olajide et al, 2004;Senga et al, 2013).…”

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

“…A new five-membered lactone ring compound, parvonin was isolated from the methanol soluble part of A. pavonina oil extracted from the seed has been reported to have membrane-stabilizing activity by reducing lytic effect on erythrocytes, exhibited by many intravenous drugs (Muhammad et al, 2005;Anna et al, 2006). The methanol seed extract has also been reported to demonstrate anti-inflammatory and analgesic activities (Olajide et al, 2004). However,usefulness of Adenanthera pavonina in stz-induced diabetic painful peripheral neuropathy remains to be explored.…”

Emulsions of oil from Adenanthera pavonina L. seeds and their protective effect

“…It has been widely naturalized in Malaysia, western and eastern Africa, and on most islands of both the Pacific and Caribbean regions. Extracts from the seeds of this extensively cultivated plant are under investigation in numerous laboratories [3][4][5], and the anti-inflammatory and analgesic effects of the A. pavonina extract have been demonstrated [6]. A. pavonina is also known as a food tree, because its seeds are often eaten by people.…”