Anti-inflammatory spirobisnaphthalene natural products from a plant-derived endophytic fungus Edenia gomezpompae

Tan, Yingzi; Guo, Zhi‐Kai; Zhu, Mengyue; Shi, Jing; Li, Wei; Jiao, Rui‐Hua; Tan, Renxiang; Ge, Hui‐Ming

doi:10.1016/j.cclet.2020.03.059

Cited by 22 publications

(10 citation statements)

References 17 publications

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“…On the other hand, S. terrestris has been described as an endophyte of other plant species such as Gloriosa superba 32 and horseradish (Armoracia rusticana), where is able to decompose various glucosinolates 33 . In turn, Edenia is a well-known genus of endophytic fungi that produce compounds of high medical interest such as anti-inflammatories 34 or antileshmanials 35 . Furthermore, the E. gomezpompae species is capable of producing highly toxic compounds for plants, which are used as natural herbicides 36 .…”

Section: B Oleracea Accession Mbg-brs0426 Mbg-brs0106 Mbg-brs0292 Mbmentioning

confidence: 99%

Brassica oleracea var. acephala (kale) improvement by biological activity of root endophytic fungi

Poveda

Zabalgogeazcoa

Soengas

et al. 2020

Sci Rep

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Brassica oleracea var. acephala (kale) is a cruciferous vegetable widely cultivated for its leaves and flower buds in Atlantic Europe and the Mediterranean area, being a food of great interest as a "superfood" today. Little has been studied about the diversity of endophytic fungi in the Brassica genus, and there are no studies regarding kale. In this study, we made a survey of the diversity of endophytic fungi present in the roots of six different Galician kale local populations. In addition, we investigated whether the presence of endophytes in the roots was beneficial to the plants in terms of growth, cold tolerance, or resistance to bacteria and insects. The fungal isolates obtained belonged to 33 different taxa. Among those, a Fusarium sp. and Pleosporales sp. A between Setophoma and Edenia (called as Setophoma/Edenia) were present in many plants of all five local populations, being possible components of a core kale microbiome. For the first time, several interactions between endophytic fungus and Brassica plants are described and is proved how different interactions are beneficial for the plant. Fusarium sp. and Pleosporales sp. B close to Pyrenophora (called as Pyrenophora) promoted plant growth and increased cold tolerance. On the other hand, isolates of Trichoderma sp., Pleosporales sp. C close to Phialocephala (called as Phialocephala), Fusarium sp., Curvularia sp., Setophoma/Edenia and Acrocalymma sp. were able to activate plant systemic resistance against the bacterial pathogen Xanthomonas campestris. We also observed that Fusarium sp., Curvularia sp. and Setophoma/Edenia confered resistance against Mamestra brassicae larvae.

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Section: B Oleracea Accession Mbg-brs0426 Mbg-brs0106 Mbg-brs0292 Mbmentioning

confidence: 99%

Brassica oleracea var. acephala (kale) improvement by biological activity of root endophytic fungi

Poveda

Zabalgogeazcoa

Soengas

et al. 2020

Sci Rep

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“…The anti-inflammatory properties of albocarbon and hybrids have been extensively studied [24][25][26][27][28][29]. Muralidharan et al [24] developed and characterized a new set of albocarbon-pyrimidine hybrids.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…To investigate if these natural hybrids had an anti-inflammatory effect, the researchers assessed nitric oxide production, as an indicator, in LPSinduced-RAW264.7 macrophagic cells. The hybrids 8 and 13 (Figure 21) displayed a solid inhibitory impact on the production of this inflammatory mediator, with IC50 values of 2.61 and 1.32 mol/L, respectively [27]. Jin et al [28] developed, identified, and tested novel albocarbon-chalcone hybrids for anti-inflammatory efficacy.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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“…Undoubtedly, natural bioactive compounds with therapeutic properties are promising candidates for drug development [2] toward treatment and effective management of these diseases. Endophytes have, indeed, shown auspicious potentials for production of metabolites with remarkable therapeutic aptitudes including anticancer, anti-inflammatory, antimalarial, antidiabetic, antioxidant, hepatoprotective, neuroprotective and antiviral [11,[14][15][16][17][18][19]. These can, therefore, be harnessed by pharmaceutical industries for development of medications, which is pivotal to ensuring good health and well-being in the society.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potentials of endophytes for healthcare sustainability

Falade

Adewole

Ekundayo

2021

Egyptian Journal of Basic and Applied Sciences

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Morbidity and mortality rates are on the upward trajectory globally, probably due to lack of effective treatments and poor healthcare. Most effective drugs are, however, characterized by serious side effects upon long usage. It is, therefore, imperative to explore natural sources for efficient therapeutics with little or no side effects. This paper outlines the therapeutic potentials of endophytes using published articles on endophytes in both Web of Science (WoS) and Scopus (1990Scopus ( -2020. Scientific evidences discussed in this review suggest endophytic microbes as reservoirs of novel bioactive compounds belonging to the following classes alkaloid, xanthones, methoxyphenols, depsipeptide, bicyclic lactones, depsidoenes, butenolides, maleimide-bearing compounds, ergosterol, spirobisnaphthalenes, benzopyran derivatives, isofuranonaphthalenone, butyrolactones, diketopiperazine, sesquiterpenoids, cytochalasin-related compounds, pestalols and cyclic pentapeptides. The identified compounds are characterized by promising therapeutic potentials such as antioxidant, anti-inflammatory, antimicrobial, anticancer, antidiabetic, antiviral, neuroprotective, and hepatoprotective properties, which are significant to healthy living and sustainable healthcare. This review further discusses the emerging potentials of endophytes in the production of antibiofilm, antimultiresistant Staphylococcus aureus (anti-MRSA) and lipase inhibitors (LIs). The prospective applications of endophytes in the development of anti-COVID-19 medications and therapeutics for the management of neglected tropical diseases (NTDs) are also advocated in this review. The therapeutic potentials of endophytes, if properly harnessed, would in no small measure contribute to good health, which is an integral part of the sustainable development goals (SDGs) of the United Nations (UN).

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Anti-inflammatory spirobisnaphthalene natural products from a plant-derived endophytic fungus Edenia gomezpompae

Cited by 22 publications

References 17 publications

Brassica oleracea var. acephala (kale) improvement by biological activity of root endophytic fungi

Brassica oleracea var. acephala (kale) improvement by biological activity of root endophytic fungi

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Therapeutic potentials of endophytes for healthcare sustainability

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