“…[18,[81][82][83][84] Likewise, germacron has been identified as the main constituent present in the rhizome extracts of C. pierreana that showed inhibitory effect on the growth of microorganisms including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus faecalis, and the fungus Candida albicans. [85] Germacrone has also been identified as the active principle responsible for the anti-inflammatory and analgesic activities Furanodiene, furanodienone, zederone, curzerenone, curzeone, germacrone, 13-hydroxygermacrone, dehydrocurdione, curcumenone, zedoaronediol, 13-hydroxycurzerenone, 1-oxocurzerenone, curcolone, procurcumenol, ermanin, curcumin, mixture of stigmast-4-en-3,6-dione and stigmasta-4,22-dien-3,6-dione, and mixture of 6ß-hydroxystigmast-4-en-3-one and 6ß-hydroxystigmasta-4,22-dien-3-one [150,151] of C. xanthorrhiza by Ozaki. [86] C. xanthorrhiza has also been shown to contain xanthorrhizol, a natural sesquiterpenoid, which possess antimetastatic effect and antimicrobial activities, as well as other curcumin analogues including 1-(4-hydroxyl-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-(1E, 6E)-1 and 6-heptadiene-3,4-dione responsible for the potent antioxidant activity of the plant extracts against auto-oxidation of linoleic acid.…”