Anti-inflammatory Role of Anthocyanins in the Prevention of Hyperhomocysteinemia-Mediated Cardiometabolic Diseases

Bhatt, Neeru; Waly, Mostafa I.; Ali, Amanat

doi:10.1007/978-3-030-57839-8_3

Cited by 2 publications

(2 citation statements)

References 113 publications

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“…20 Anthocyanin and andrographolide compounds can inactivate NFk-B so that the pathogenesis of atherosclerosis does not occur. [21][22][23]…”

Section: Resultsmentioning

confidence: 99%

Evaluation of In Vivo Anti-dyslipidemic Activity of the Combination of Andrographis paniculata Extract and Ipomea batatas Leaf Extract

2021

TJNPR

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Dyslipidemia is a condition of abnormal blood lipid levels in the form of total cholesterol (TC), triglyceride (TG) levels, lowdensity lipoprotein (LDL-C) above normal values and high-density lipoprotein (HDL-C) levels below normal values. 1 Levels of TC, TG and LDL-C that exceed normal limits, while the level of HDL-C that is below normal limit will trigger diseases such as diabetes mellitus, atherosclerosis, stroke, hypertension, and cardiovascular disorders. 2 Several factors cause a rise in TC, TG and LDL-C levels and cause a decline in HDL-C levels; one of such factors is diet. Fat-rich diets are one of the triggering factors for dyslipidemia. 2 Andrographis paniculata is a plant that has the potential to reduce lipid levels in the blood. Andrographolide is a lactone terpene compound in Andrographis paniculata and is responsible for the pharmacological activity of Andrographis paniculata, one of such activity is antihyperlipidemic activity. [3][4][5] Apart from andrographolide, flavonoids are class of compounds that can reduce hyperlipidemia. 6 One of the plants that grow in Indonesia that contain anthocyanins; a type of flavonoid compounds is Ipomea batatas. 7

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“…20 Anthocyanin and andrographolide compounds can inactivate NFk-B so that the pathogenesis of atherosclerosis does not occur. [21][22][23]…”

Section: Resultsmentioning

confidence: 99%

Evaluation of In Vivo Anti-dyslipidemic Activity of the Combination of Andrographis paniculata Extract and Ipomea batatas Leaf Extract

2021

TJNPR

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“…10 Moderate intake of dietary anthocyanin has been reported to decrease homocysteine, which is an independent biomarker of inflammation in cardiovascular thrombotic disease. 36 Although homocysteine was not identified by 1 H NMR, changed dimethylglycine by anthocyanins might affect the inflammatory status by influencing homocysteine synthesis.…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of Acylated and Nonacylated Anthocyanins on Urine Metabolic Profile during the Development of Type 2 Diabetes in Zucker Diabetic Fatty Rats

Chen

Wei

Zhang

et al. 2022

J. Agric. Food Chem.

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The effect of nonacylated and acylated anthocyanins on urinary metabolites in diabetic rats was investigated. Nonacylated anthocyanins extract from bilberries (NAAB) or acylated anthocyanins extract from purple potatoes (AAPP) was given to Zucker diabetic fatty (ZDF) rats for 8 weeks at daily doses of 25 and 50 mg/kg body weight. 1 H NMR metabolomics was applied to study alterations in urinary metabolites from three time points (weeks 1, 4, and 8). Both types of anthocyanins modulated the metabolites associated with the tricarboxylic acid cycle, gut microbiota metabolism, and renal function at weeks 1 and 4, such as 2oxoglutarate, fumarate, alanine, trigonelline, and hippurate. In addition, only a high dose of AAPP decreased monosaccharides, formate, lactate, and glucose levels at week 4, suggesting improvement in energy production in mitochondria, glucose homeostasis, and oxidative stress. This study suggested different impacts of AAPP and NAAB on the metabolic profile of urine in diabetes.

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Anti-inflammatory Role of Anthocyanins in the Prevention of Hyperhomocysteinemia-Mediated Cardiometabolic Diseases

Cited by 2 publications

References 113 publications

Evaluation of In Vivo Anti-dyslipidemic Activity of the Combination of Andrographis paniculata Extract and Ipomea batatas Leaf Extract

Evaluation of In Vivo Anti-dyslipidemic Activity of the Combination of Andrographis paniculata Extract and Ipomea batatas Leaf Extract

Effect of Acylated and Nonacylated Anthocyanins on Urine Metabolic Profile during the Development of Type 2 Diabetes in Zucker Diabetic Fatty Rats

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