Anti-inflammatory Properties of the Genus Symphytum L.: A Review

Mahmoudzadeh, Elaheh; Nazemiyeh, Hossein; Hamedeyazdan, Sanaz

doi:10.5812/ijpr.123949

Cited by 7 publications

(13 citation statements)

References 113 publications

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“…Studies have shown that rosmarinic acid can reduce oxidative stress and inhibit the production of inflammatory cytokines in the skin, leading to improved skin health [43]. Comfrey also contains tannins and pyrrolizidine alkaloids, which contribute to its anti-inflammatory and wound-healing effects [44][45]. (4) S. dulcamara stems have been traditionally employed in folk medicine as a narcotic agent and as a remedy for conditions such as rheumatism, migraine, and severe inflammation [91].…”

Section: Taraxacum Officinale Web Family -Compositaementioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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According to the eminent scholar, philosopher, and physician Avicenna, "the doctor has three tools: the word, the plant, the knife." The plant kingdom is recognized as humanity's earliest and most ancient healing source, employed for the management and prevention of illnesses. Tracing back through history, the most ancient documented proof of plants' utilization in medicine dates back to a Sumerian clay slab discovered in Nagpur roughly 5000 years ago. This artifact included a compilation of twelve medicinal recipes that involved over 250 diverse plant species. Sumerian healers extracted powders and infusions from plant roots and stems, while also crediting healing properties to pears and figs. Additionally, they utilized dried and ground young shoots of willow and plum trees, pine and fir needles as a component in compresses and poultices. Often, powders from animal and mineral sources were blended with those extracted from dried and crushed plants. Notably, in addition to water, wine and beer served as solvents. Thus, at least 80 centuries ago, people utilized the most uncomplicated medicinal plant-based preparations for treatment [1]. The "Pen T'Sao," an ancient Chinese text on roots and herbs, authored by Emperor Shen Nung approximately 2500 BC, contains descriptions of 900 medicaments (comprising dried components of medicinal plants). Several of these substances are still in use today, including Rhei rhisoma, camphor, Theae folium, Podophyllum, great yellow gentian, ginseng, datura, cinnamon bark, and ephedra [2]. Regarding Kazakh folk medicine, an area that has yet to be fully explicated and substantiated, it can be stated that the traditional medicinal knowledge of the Kazakh people transcends the mere treatment of ailments and rests on robust theoretical underpinnings. Oteiboydak Tleukabyluly (1388-1478), an astute healer and prominent figure in Kazakh folk medicine during the 15th century, comprehensively explicated the secrets of the healing art in his medical and ethnographic work "Medical Narrative," which he composed between 1466 and 1473 at the behest of az-Zhanibek Khan, who held him in high esteem as a great healer. This medical encyclopedia delineates the functions of various organs of the human body and provides a catalogue of the primary diseases associated with them. Furthermore, it includes a meticulous description of the methods used in traditional medicine at present, such as setting bones, listening to the pulse, and incantations. Through practical experimentation and experimentation conducted in the steppe laboratory, the healer formulated a total of 1,108 different medicinal compounds, of which 858 were derived from medicinal plants, 318 were extracted from animal organs, and roughly 60 were sourced from metals. The moniker "Teacher without a teacher" was bestowed on Oteiboydak Tleukabylov, who discovered methods for treating 1,050 different diseases [3]. At present, the employment of phytotherapy has gained widespread acceptance on a global scale. According to the World Health Organization's (WHO) global review of national policies concerning traditional, complementary, and alternative medicine, as well as the regulation of herbal medicines, there is an evident growth in the European and Asian market for herbal medicines [4]. Kazakhstan boasts a natural flora of over 6,000 plant species [5]. The exact number of medicinal plant species present in Kazakhstan remains uncertain, as the list continues to expand annually. More than 150 plant species have been employed in both official and folk medicine for various ailments. This review focuses on a selection of medicinal plants growing within the territory of the Republic of Kazakhstan that have traditionally been used to alleviate skin diseases. In conducting this study (2010-2023), emphasis was placed on the plants' phytochemical composition, with a particular focus on the principal components responsible for their therapeutic effects against inflammatory skin conditions such as dermatitis, atopic dermatitis, and eczema.

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Section: Taraxacum Officinale Web Family -Compositaementioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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“…Der Nachweis der PAs Symlandin und Echimidin weist auf eine Verfälschung mit anderen Symphytum-Arten hin 7 14 . In Wurzeln wurden 1380–8320 μg PAs pro Gramm nachgewiesen, in Blättern 15–55 μg PAs/g 7 14 34 .…”

Section: Beinwell-inhaltsstoffeunclassified

“…2,1 % gemessen [24]. Symphytum-Kraut enthielt im Mittel 9,4 mg Allantoin pro Gramm, die Wurzel 25,8 mg/g [34]. Nach Entfernung des Schleims kam es zu einem Anstieg der Rosmarinsäure, von Globoidnan A, Globoidnan B und Rabdosiin.…”

Section: Beinwell-inhaltsstoffeunclassified

“…B. den DPPH-, ABTS-, FRAPund TPC-Assays und durch 15-Lipoxygenasehemmung. Im MTT-Assay zur Messung der zellulären Stoffwechselaktivität stimulierte der Wirkstoff die Viabilität, Proliferation und Zytotoxizität der Zellen [45] [46], siehe auch [34] [44]. Die LPS-stimulierte Freisetzung von IL-1ß ex-vivo in-vitro wurde gehemmt.…”

Section: Antoxidative Und Antientzündliche Wirkungunclassified

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Zur Wirksamkeit von Symphytum officinale

Chrubasik-Hausmann,

Vlachojannis

2023

Zeitschrift für Komplementärmedizin

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SummaryIn der Volksmedizin werden Zubereitungen aus Symphytum officinale zur Wundbehandlung, bei Prellungen und Verstauchungen eingesetzt. Die European Medicines Agency hat 2015 die Datenlage zum Wirkstoff und zu den pharmakologischen und klinischen Studien zusammengefasst und die Beinwellwurzel unter „traditional use“ eingestuft. Das Prädikat umfasst Pflanzenmedizin, die seit mehr als 30 Jahren in Europa angewendet wird. Trotz plausibler Wirksamkeit reichte der Wissensstand nicht für das Prädikat „well-establisheduse“. Dies hätte eine detaillierte Kenntnis des Wirkstoffs erfordert, außerdem einen umfassenden Nachweis für die antioxidative, antientzündliche und wundheilungsfördernde Wirkung sowie für die Wirksamkeit in klinischen Studien. Die vorliegenden Studien weisen auf eine mäßige Evidenz der Wirksamkeit von Zubereitungen aus dem Beinwell bei Sprunggelenksdistorsion, Knie- und Rückenschmerzen. Bei Hämatomen, Dekubitus, stumpfen Traumata ohne und mit Hautabschürfungen gibt es Hinweise auf Wirksamkeit. Beweisend angelegte Studien müssten jetzt die Wirkgrößen bei den einzelnen Indikationen definieren. Beinwell-Zubereitungen, bei denen mithilfe eines Spezialverfahrens die Pyrrolizidinalkaloide entfernt wurden, können ohne Bedenken auch langfristig eingesetzt werden.

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“…Comfrey also contains tannins and pyrrolizidine alkaloids, which contribute to its anti-inflammatory and wound-healing effects [ 342 , 343 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

et al. 2023

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The skin shows the physiological condition of the body’s organs and systems that prevent infections and physical damage. Throughout the ages, in folk medicine, phytotherapy was considered a primary form of treatment in all countries, including Kazakhstan, due to the abundance and availability of plant-based remedies. This paper discusses several medicinal plants that are traditionally used in the treatment of skin diseases in the Republic of Kazakhstan. The chemical composition of these plants was analyzed, with a particular focus on the biologically active basic compounds responsible for their therapeutic efficiency in treating skin ailments.

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Anti-inflammatory Properties of the Genus Symphytum L.: A Review

Cited by 7 publications

References 113 publications

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Zur Wirksamkeit von Symphytum officinale

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

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