Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat

Guardia, Teresita; Rotelli, Alejandra Ester; Juárez, Américo; Pelzer, Lilian Eugenia

doi:10.1016/s0014-827x(01)01111-9

Cited by 594 publications

(384 citation statements)

References 17 publications

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“…Rutin, being a secondary plant metabolite, is one of the highly valued compounds. Its antifungal, antibacterial, antiinflammatory and anticancer properties and the ability of radical scavenging are most frequently discussed (Biesaga 2011;Guardia et al 2001;Mohd Zainol et al 2009;Navarro-Núñez et al 2008;Wang et al 2011;Yang et al 2008;You et al 2010). These properties require better knowledge of rutin itself, its transformations, and its occurrence and metabolism in plants.…”

Section: Introductionmentioning

confidence: 99%

Does the Plant Matrix Type Have Impact on Rutin Transformation During Its Extraction?

2016

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Rutin is a flavonoid glycoside found in many plants. It is used as medication and an ingredient of numerous multivitamin preparations and herbal remedies due to its biomedical activity. The present paper deals with transformation processes of rutin during its extraction by methanol, ethanol, and their aqueous mixtures from Aronia melanocarpa (M.) E. and Sambucus nigra L. fruits, Hypericum perforatum L. herb, and Tussilago farfara L. leaves, known as ones of the most riches in rutin plant materials. It has been established that the transformation degree of rutin during its extraction depends not only on extraction time and extractant type but also, to a high degree, on the plant matrix type. Differences in the degree of rutin transformation are influenced by the matrix components in the examined plants. The reported results are particularly important for researchers investigating plant metabolism and looking for new plant components.

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Section: Introductionmentioning

confidence: 99%

Does the Plant Matrix Type Have Impact on Rutin Transformation During Its Extraction?

2016

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“…Hesperidin is a component extracted from citrus pith that exerts several potential health-beneficial effects, which have been demonstrated in animal and in vitro studies. These include the promotion of bone health (Kalu, 1991), lipid-lowering effects (Park et al, 2001), antioxidant properties (Miyake et al, 1998), cardioprotective effects (Ohtsuki et al, 2002), and anti-cancer (Tanaka et al, 2000) and anti-inflammatory properties (Guardia et al, 2001). However, the bioavailability of hesperidin is low and occurs only in the distal part of the gastrointestinal tract in humans due to the lack of the enzyme a-L-rhamnosidase in the small intestine (Nielsen et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Physiological and biochemical characterization of the two α-l-rhamnosidases of Lactobacillus plantarum NCC245

et al. 2009

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This work is believed to be the first report on the physiological and biochemical characterization of a-L-rhamnosidases in lactic acid bacteria. A total of 216 strains representing 37 species and eight genera of food-grade bacteria were screened for a-L-rhamnosidase activity. The majority of positive bacteria (25 out of 35) were Lactobacillus plantarum strains, and activity of the L. plantarum strain NCC245 was examined in more detail. The analysis of a-L-rhamnosidase activity under different growth conditions revealed dual regulation of the enzyme activity, involving carbon catabolite repression and induction: the enzyme activity was downregulated by glucose and upregulated by L-rhamnose. The expression of the two a-L-rhamnosidase genes rhaB1 and rhaB2 and two predicted permease genes rhaP1 and rhaP2, identified in a probable operon rhaP2B2P1B1, was repressed by glucose and induced by L-rhamnose, showing regulation at the transcriptional level. The two a-L-rhamnosidase genes were overexpressed and purified from Escherichia coli. RhaB1 activity was maximal at 50 6C and at neutral pH and RhaB2 maximal activity was detected at 60 6C and at pH 5, with high residual activity at 70 6C. Both enzymes showed a preference for the a-1,6 linkage of L-rhamnose to b-D-glucose, hesperidin and rutin being their best substrates, but, surprisingly, no activity was detected towards the a-1,2 linkage in naringin under the tested conditions. In conclusion, we identified and characterized the strain L. plantarum NCC245 and its two a-L-rhamnosidase enzymes, which might be applied for improvement of bioavailability of health-beneficial polyphenols, such as hesperidin, in humans.

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“…Rutin was first isolated from Ruta graveolens which is the source of the name. It inhibits the platelet aggregation [17] and decreases capillary permeability, improving blood circulation, anti-inflammatory activity, and it inhibit aldose reductase [18,19]. Gallic acid is a type of phenolic acid and it is formed from 3-dehydroshikimate with shikimate dehydrogenase to produce 3,5-didehydroshikimate of tautomerizes to form the gallic acid [20], and it is found in a number of plants containing high antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Potentials and Simultaneous Estimation of Quercetin, Rutin, and Gallic Acid in Curcuma Species

Sangilimuthu

Karpagavalli

et al. 2017

Asian J Pharm Clin Res

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Objective: This study was designed to provide simple and cost-effective methods to quantify the biologically active phytoconstituents such as rutin, quercetin, and gallic acid from Curcuma species and evaluation of the antioxidant potential of different parts with different solvent extracts of Curcuma species.Methods: Ultraviolet-visible spectrophotometer was used for the analysis of quercetin, rutin, gallic acid and total flavonoid content of Curcuma species extracts. Antioxidant potential of Curcuma species extracts were evaluated using 2-2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.Results: Ethyl acetate extract of Curcuma aromatica rhizome, aerial part contain higher quantity of quercetin and rutin compared to the other extracts, and also Curcuma species such as Curcuma longa and Curcuma amada contains high antioxidant capacity. The total flavonoid content was high in ethyl acetate extract of Curcuma aromatica as 88.35±0.25 μg/g dry weight of quercetin equivalents. Conclusion:Different extracts of Curcuma species possess good free radical scavenging activity and the IC 50 of Curcuma amada aerial part, Curcuma longa aerial part, and Curcuma aromatica rhizome was 61.65±1.75, 62.95±1.85, and 89.40±0.15 (μg/ml), respectively. The Curcuma species contains high total flavonoid content and antioxidant potential.

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Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat

Cited by 594 publications

References 17 publications

Does the Plant Matrix Type Have Impact on Rutin Transformation During Its Extraction?

Does the Plant Matrix Type Have Impact on Rutin Transformation During Its Extraction?

Physiological and biochemical characterization of the two α-l-rhamnosidases of Lactobacillus plantarum NCC245

Antioxidant Potentials and Simultaneous Estimation of Quercetin, Rutin, and Gallic Acid in Curcuma Species

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