Anti-Inflammatory Properties of Botanical Extracts Contribute to Their Protective Effects in Brain Edema in Cerebral Ischemia

Panickar, Kiran S.

doi:10.1016/b978-0-12-411462-3.00001-1

Cited by 4 publications

(3 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferulic acid, rutin, and quercetin were reported to have antithrombotic and anticoagulant activities (Choi et al, 2015;Hemalatha et al, 2016). This effect was also pointed out by Panickar (2015), who stated that polyphenols, saponins, and alkaloids found in plant extracts have anti-inflammatory properties and a protective effect against cytotoxic cerebral edema in cerebral ischemia, decreasing its neural damage.…”

Section: Quinoa In the Prevention And Treatment Of Cvdsmentioning

confidence: 81%

Nutritional, therapeutic, and technological perspectives of quinoa ( Chenopodium quinoa Willd.): A review

Brito

Chantelle

Magnani

et al. 2022

Food Processing Preservation

View full text Add to dashboard Cite

Quinoa (Chenopodium quinoa Willd) is a plant whose seeds have important nutritional and technological potential as promising ingredients for the food industry because of their wide range of possible uses and functional properties. The purpose of the present review is to identify the current studies that evaluate quinoa’s nutritional potential and their technological qualities, and possible health benefits. Studies have reported substantial variations in quinoa nutrient concentrations, depending on production characteristics, plant variety, and extraction methods. Studies have also reported the technological potential of quinoa as an ingredient in food formulations and the prevention and treatment of various pathologies. However, further researches involving humans are needed to clarify how quinoa can be explored to contribute to food security in several institutional spheres. Practical applications Quinoa is a seed rich in proteins with high aminoacidic bioavailability, a source of carbohydrates, dietary fibers, vitamins and minerals, predominantly polyunsaturated lipids, and a high content of bioactive substances. This composition gives the seeds several possibilities of use, whether to compose a healthy diet or for use in the food industry. In these perspectives, several studies have pointed out antimicrobial, antioxidant, and anti‐inflammatory properties associated with health promotion and with potential benefits against cardiovascular diseases, obesity, diabetes, and even cancer. As for its technological characteristics, it does not have gluten in its composition, but it has a high potential for forming emulsions and gelling capacity, and can be applied in the formulation of various bakery products, yogurts, soups, etc. Thus, quinoa has been reported as an important functional ingredient used in foods around the world.

show abstract

Section: Quinoa In the Prevention And Treatment Of Cvdsmentioning

confidence: 81%

Nutritional, therapeutic, and technological perspectives of quinoa ( Chenopodium quinoa Willd.): A review

Brito

Chantelle

Magnani

et al. 2022

Food Processing Preservation

View full text Add to dashboard Cite

show abstract

“…The high abundance of PAs that characterise these extracts (Table 1) could explain these results. This molecular category is well known for its use in nutritional supplements, functional foods, in the cosmetic and pharmaceutical products (Nagasako-Akazome 2014;Xia et al 2014;Panickar 2015;Martinez et al 2017) and these extraction strategies could implement the revaluation of this by-product, making it a new profitable resource. VCR extracts, in turn, showed higher polyphenolic content than VCB samples, with an average difference of 39%, most probably because of the presence of anthocyanins.…”

Section: Discussionmentioning

confidence: 99%

Chemical characterisation, antioxidant and antimicrobial screening for the revaluation of wine supply chain by-products oriented to circular economy

Tacchini

Burlini

Bernardi

et al. 2018

Plant Biosystems - An International Journal Dealing with all As

View full text Add to dashboard Cite

Aim of the project was the bioassay guided optimisation of extraction methods applied to wine chain by-product to obtain extracts, fractions and biologically active biomolecules with a possible use in the nutraceutical and cosmeceutical industry. Exhausted red and white grape marc were extracted using water:ethanol 50:50 with ultrasound assisted extraction and NaviglioV R technology; and also with supercritical fluid extraction (SFE) and steam-distillation obtaining different phytocomplexes. Each extract was characterised by different molecular category: exhausted red grape marc (VCR) by anthocyanins, exhausted white grape marc (VCB) by flavonoids, and grapeseed (VIN) by proanthocyanins. SFE and steam-distillation, instead, highlighted the presence of fatty acids and their ester in every matrix, but terpenoids were not revealed at level major or equal than 0.1%, except for manoyl oxide in VCR (2.89%). VIN was the most abundant matrix in polyphenols (506.24 ± 55.91 mg gallic acid/g dried extract), and it showed the highest antioxidant activity (IC 50 of 4.30 lg/mL). Regarding the antimicrobial activity, the hydroalcoholic extracts from VCR, VCB and VIN were tested but no noteworthy activities have been recorded.

show abstract

“…The death of neurons and cerebral edema are the main consequences of stroke. Inflammatory processes play a key role in exacerbating stroke-related brain damage (Panickar, 2015). A variety of mechanisms are responsible for ischemic brain damage.…”

Section: Introductionmentioning

confidence: 99%

Attenuating NF-κB/VCAM-1 Expression in the Middle Cerebral Artery Occlusion Model by Viola Odorata: Protection Against Ischemia-Reperfusion Injury in Rats

Karimifar

Alipanah

Hekmat

et al. 2022

BCN

View full text Add to dashboard Cite

Background: The death of neurons and cerebral edema are the main consequences of stroke. However, inflammatory processes play a key role in aggravating cerebral damage following stroke. The aim of this study was to investigate the effects of Viola odorant extract (VOE) on infarct volume (IV), neurologic deficits (ND), and expression of NF-κB and VCAM-1 in the MCAO model. Method: The animals were randomly separated into 5 groups: (1) control group, (2) vehicle-treated group, (3) MCAO group, (4) VOE25 group, (5) VOE50 group, (6) VOE75 group (n=12). VOE (25, 50, and 75 mg/kg) or distilled water were administered daily for 30 days. Two hours after the last gavage, rats were exposed to 60 minutes of MCAO. Twenty-four hours later, the IV, ND, and NF-κB/VCAM-1 expression were evaluated. Results: V. odorata extract (VOE) exhibited excellent neuroprotective effects by reducing infarct volume (mainly in the core and sub-cortex areas), and induced down-regulation of NF-kB and VCAM-1 expression. Conclusion: This finding suggests that V. odorata could also activate intracellular pathways, which ultimately reduces the expression of NF-κB and VCAM-1 and be useful for developing a novel medical herbs for treating cerebral ischemia.

show abstract

Anti-Inflammatory Properties of Botanical Extracts Contribute to Their Protective Effects in Brain Edema in Cerebral Ischemia

Cited by 4 publications

References 138 publications

Nutritional, therapeutic, and technological perspectives of quinoa ( Chenopodium quinoa Willd.): A review

Nutritional, therapeutic, and technological perspectives of quinoa ( Chenopodium quinoa Willd.): A review

Chemical characterisation, antioxidant and antimicrobial screening for the revaluation of wine supply chain by-products oriented to circular economy

Attenuating NF-κB/VCAM-1 Expression in the Middle Cerebral Artery Occlusion Model by Viola Odorata: Protection Against Ischemia-Reperfusion Injury in Rats

Contact Info

Product

Resources

About