Anti-Inflammatory Properties In Vitro and Hypoglycaemic Effects of Phenolics from Cultivated Fruit Body of Phellinus baumii in Type 2 Diabetic Mice

Abstract

Dietary intervention in type 2 diabetes mellitus (T2DM) is a hotspot in international research because of potential threats to human health. Phellinus baumii, a wild fungus traditionally used as a food and medicine source, is now cultivated in certain East Asian countries, and is rich in polyphenols, which are effective anti-inflammatory ingredients useful in treatment of T2DM, with fewer side effects than drugs. To examine the hypoglycaemic effects of Phellinus baumii phenolics (PPE), the metabolite profiles of T2DM mice induced by streptozotocin after PPE intervention were systematically analyzed. Here, 10 normal mice were given normal saline as control group, and 50 model mice were randomly assigned to five groups and daily intragastric administrated with saline, metformin (100 mg/kg), and PPE (50, 100, 150 mg/kg of body weight), for 60 days. The pro-inflammatory factor contents of lipopolysaccharide stimulation of RAW 264.7 cells were decreased in a dose-dependent manner after PPE treatment, we propose that PPE could exert anti-inflammatory properties. PPE could also effectively reduce blood glucose levels, increased insulin sensitivity, and improved other glucolipid metabolism. Q-PCR results suggested that the hypoglycemic effects of PPE might be through activating IRS1/PI3K/AKT pathway in diabetic mice. These results suggest that PPE has strong potential as dietary components in the prevention or management of T2DM.

Simiao Wan and its ingredients alleviate type 2 diabetes mellitus via IRS1/AKT2/FOXO1/GLUT2 signaling

“…The insulin-mediated IRS1/AKT/FOXO1 signaling pathway is closely related to pancreatic β-cell function, liver glucose metabolism, and the occurrence and development of T2DM ( 26 ). In recent years, the IRS1/AKT/FOXO1 signaling pathway has attracted wide attention as a key link in the pathogenesis and treatment of T2DM.…”

Inhibitory Effect of Phellinus baumii Extract on CFA-Induced Inflammation in MH-S Cells through Nuclear Factor-κB and Mitogen-Activated Protein Kinase Signaling Pathways

“…As medicinal herbs have been widely studied for its anti-inflammatory properties [ 20 , 21 ], we desire to investigate effective medicinal herbs that have potent medicinal properties. Phellinus baumii has long been used as herbal medicine in Asia, particularly China, Korea, and Japan for the treatment of a variety of ailments, including diabetes, hypercholesterolemia, and most notably cancer [ 11 , 22 ]. Earlier studies showed that PBE can block NF- κ B, transcription factor, which is a crucial regulator in the inflammatory cascade.…”

“…Phellinus baumii , a wild fungus, has traditionally been used as healthy food or a folk tonic in East Asia because of its multiple physiological functions, including blood lipid level-lowering, antitumor, antiinfluenza, and antioxidation capacities, and DNA damage-protecting, immune-stimulating, and antidiabetic activities [ 11 – 13 ]. Polysaccharides, polyphenols, and flavonoids, which have a wide spectrum of health benefits and biological activities, have been reported as the principal bioactive ingredients of the Phellinus fungus in modern medical research [ 14 – 16 ].…”

“…Polysaccharides, polyphenols, and flavonoids, which have a wide spectrum of health benefits and biological activities, have been reported as the principal bioactive ingredients of the Phellinus fungus in modern medical research [ 14 – 16 ]. The Phellinus fungus includes various yellow polyphenolic chemicals, such as hispidin, that have demonstrated substantial biological effects and have been used to treat diabetes, bacterial, and viral infections, ulcers, and cancer, according to prior studies [ 11 , 17 ].…”

Research Progress of Bioactive Components in Sanghuangporus spp.

“…The general process of studying the Sanghuang species often starts from extracting the desired components. To extract them from the Sanghuang species, the fruiting bodies are typically dried and turned into powder, followed by hot water extraction or ethanol extraction, depending on whether the target material comprises water-soluble polysaccharides or other ethanol-soluble components [ 2 , 4 , 34 , 35 , 36 , 37 ]. These two methods, often assisted by ultrasonic devices, are widely used due to their undeniable advantages: they are cheap and easy to perform [ 2 , 13 , 14 , 21 , 32 , 37 , 38 , 39 , 40 , 41 , 42 ].…”