Anti-inflammatory profile of paricalcitol in kidney transplant recipients

Donate-Correa, Javier; Henríquez-Palop, Fernando; Martín‐Núñez, Ernesto; Hernández-Carballo, Carolina; Ferri, Carla; Pérez‐Delgado, Nayra; Muros‐de‐Fuentes, Mercedes; Mora‐Fernández, Carmen; Navarro‐González, Juan F.

doi:10.1016/j.nefroe.2017.11.010

Cited by 2 publications

(3 citation statements)

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“…In fact, the relationship between serum vitamin D levels and inflammatory markers has been discussed in nonstroke patients. Few evidence coming from observational studies supports a primary anti‐inflammatory role of vitamin D (Azizieh, Alyahya, & Dingle, ; De Vita et al., ; Donate‐Correa et al., ; Mateen, Moin, Shahzad, & Khan, ). An observational investigation conducted in 957 old individuals, Laird et al.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

et al. 2018

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IntroductionLow serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology of PSD. The relationship between vitamin D levels and inflammatory markers has been discussed in nonstroke individuals. The purposes of this study were to explore the relationship between vitamin D levels and inflammatory markers in acute stroke patients and examine the effect of vitamin D and inflammatory markers on PSD.MethodsA total of 152 acute stroke patients were recruited. Serum levels of 25‐hydroxyvitamin D and inflammatory markers were measured by standardized laboratory methods. Depression symptoms were assessed with the 17‐item Hamilton Depression Scale (HAMD‐17). Patients with the HAMD‐17 scores ≥7 were identified to have depression symptoms.ResultsSerum vitamin D levels were negatively correlated with serum levels of interleukin‐6 and high‐sensitivity C‐reactive protein (hsCRP) (r = −.244, p = .002; r = −.231, p = .004). Multiple regression analysis showed that interleukin‐6 and hsCRP levels were associated with vitamin D levels (B = −0.355, p = .003; B = −2.085, p = .006), whereas age, height, weight, leukocyte count, neutrophil ratio, and lymphocyte rate could be omitted without changing the results. In multivariate analyses, the serum levels of vitamin D and interleukin‐6 were associated with the development of PSD after adjusted possible variables (OR = 0.976, 95% CI: 0.958–0.994, p = .009; OR = 1.029, 95% CI: 1.003–1.055, p = .027).ConclusionsSerum vitamin D levels are inversely associated with the levels of interleukin‐6 and hsCRP, suggesting a potential anti‐inflammatory role for vitamin D in stroke individuals.

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Section: Discussionmentioning

confidence: 99%

“…() in 867 older adults. Paricalcitol, a selective VDR activator, has been found to reduce serum levels of IL‐6 and TNF‐α (Donate‐Correa et al., ).…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

et al. 2018

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“…Paricalcitol treatment was observed to significantly decrease serum levels of IL-6, TNF, and TGF-βin kidney transplant recipients with secondary hyperparathyroidism or proteinuria. However, it was also noted that circulating high sensitivity CRP and a range of cytokines and inflammatory molecules were not significantly affected by paricalcitol treatment in this population ( 28 – 31 ). The network of inflammatory cytokines and molecules is intricate.…”

Section: Discussionmentioning

confidence: 66%

Vitamin D supplementation reduced blood inflammatory cytokines expression and improved graft function in kidney transplant recipients

Bai

et al. 2023

Front. Immunol.

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BackgroundChronic allograft dysfunction(CAD) is the leading cause of graft loss in kidney transplant recipients (KTRs). Inflammatory process is believed to be one of the major contributors to CAD. The aim of this study is to explore the anti-inflammatory effect of vitamin D (VD) supplementation in KTRs and its role in the graft function improvement(protection).MethodsA retrospective cohort of 39 KTRs with chronic antibody mediated rejection(CAMR)or stable renal function and a prospective cohort of 42 KTRs treated or untreated with VD were enrolled. Serum levels of vitamin D metabolism and serum inflammatory cytokines, renal graft function, and routine blood biomarkers were tested and dynamically tracked within 12 months post-transplant.ResultsCompared with the stable group, the CAMR group exhibited significantly elevated serum levels of inflammatory cytokines IL-1β, IFN-γ, IL-2, IL-10, IP-10, and HMGB1 (P <0.05). The supplementation of vitamin D effectively increased the serum concentration of vitamin D in kidney transplant recipients (KTRs) in the treated group. During the course of treatment, the treated group exhibited a gradual increase in eGFR levels, which were significantly higher than those observed in the untreated group at 12 months post-transplant (p<0.05). Notably, as eGFR improved, there was a significant decrease in levels of IL-1β, IFN-γ, IL-2, IL-10, IP-10 and HMGB1 in the treated group compared to the untreated group (P<0.05).ConclusionThis study confirmed that immune-inflammation is a crucial factor in the development of CAD in KTRs.VD deficiency impairs its anti-inflammatory activity. By assisting in the regulation of excessive immune inflammation and restoration of immune homeostasis, effective VD supplementation contributes to protection and maintenance of graft function in KTRs.

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Anti-inflammatory profile of paricalcitol in kidney transplant recipients

Cited by 2 publications

References 39 publications

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

Vitamin D supplementation reduced blood inflammatory cytokines expression and improved graft function in kidney transplant recipients

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