Anti-inflammatory potential of hentriacontane in LPS stimulated RAW 264.7 cells and mice model

Khajuria, Vidushi; Gupta, Shilpa; Sharma, Neha; Kumar, Ashok; Lone, Nazir A.; Khullar, Mowkshi; Dutt, Prabhu; Sharma, Parduman R.; Bhagat, Asha; Ahmed, Zabeer

doi:10.1016/j.biopha.2017.05.063

Cited by 39 publications

(22 citation statements)

References 43 publications

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“…[68] It was found that hentriacontane (52) significantly reduced all the parameters of inflammation in the conducted experiments at all tested concentrations either in vitro (10, 5 and 1 μM) or in vivo (5, 2 and 1 mg kg À 1 ). [69] Alcohols Alcohols, 9 in total, were identified in the hexane extracts of S. maritima and P. maritima representing 14.6 % and 17.2 % of the identified compounds, respectively. Among these, two sugar alcohols, namely glycerol (55) and galactitol (57) were found, the remaining are long-chain alcohols with several carbons between 22 and 32 (56 and 58-63).…”

Section: Fatty Acids and Their Ester Derivativesmentioning

confidence: 99%

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Faustino

Silva

et al. 2020

Chemistry & Biodiversity

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Spartina maritima and Puccinellia maritima are two fascinating but underexplored halophytic species, and herein, the chemical profile of their hexane extracts is described. Terpenoids and sterols were the most abundant chemical groups in both species. The second dominant class was alcohols and the third esters of fatty acids. The chemical lipophilic profile of both S. maritima and P. maritima is herein reported for the first time. Through the accomplished data, it is possible to conclude that these species are rich in essential compounds that can be relevant to endorse their use as nutraceuticals. Furthermore, through a principal component analysis, a clear differentiation between the taxa was achieved, which indicates that their response to salinity stress is different. That fact was confirmed by the pathway enrichment analysis, which showed that the induced changes in metabolic pathways vary in each species.

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Section: Fatty Acids and Their Ester Derivativesmentioning

confidence: 99%

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Faustino

Silva

et al. 2020

Chemistry & Biodiversity

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“…Similarly, for anti-inflammatory activity, SgH produced the highest activity, similar to that of Indo at the same dose. This corroborated by hentriacontane wich exhibited suppressive potential on NO, PGE2 and LTB4 on LPS-induced translocation of NF-kB in RAW 264.7 (Khajuria et al,2017). However, this was mainly due to the presence of compounds such as spathulenol which was tested in a pleurisy model that induces inhibition of inflammatory parameters such as leukocyte migration and protein extravasation (Do Nascimento, et al, 2018), and to the triterpenes, α, β-sitosterol, β-amyrin and lupeol that in various assay models, demonstrated high anti-inflammatory activity (Melo et al, 2011;Valerio et al, 2011;Sánchez-Burgosa et al, 2015).…”

Section: Discussionmentioning

confidence: 52%

Spasmolytic, Anti-Inflammatory, and Antioxidant Activity of Salvia Gesneriflora Lindley

Gómez-Rivera¹,

González-Cortazar²,

Gallegos-García³

et al. 2018

Afr J Tradit Complement Altern Med

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Background: Salvia gesneriflora Lindley is employed in traditional Mexican medicine for the treatment of several diseases. Materials and Methods: The chromatographic profile of three extracts (SgH, SgD and SgM) of this plant allowed the identification of 11 components in SgH, the presence of rosmarinic (1), chlorogenic (2) and caffeic (3) acids and quercetin glucoside (4) in SgM and of ursolic acid (5) in SgD. The spasmolytic (electrically induced contractions of guinea-pig ileum), anti-inflammatory (edema in mouse ear) and antioxidant potential (DPPH, ABTS and FRAP assays) of the extracts were evaluated. Results: SgM showed the highest percentage of relaxation (80.67 ± 1.633%) with no significant difference (p

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“…Although LPS-induced inflammation studies have been investigated in many mouse models, 41 , 42 , 43 , 44 one limitation in those wild-type murine systems is the reliance on an entirely murine-based immune response to inflammation, thus resulting in different pathological conditions and some contradictory results in therapeutic efficacy studies when compared with those obtained in human patients. An LPS-induced inflammation animal model that can harbor human cells and mimic the human immune system may be useful to reduce and minimize the discrepancies between the murine and human immune systems, thus providing a better understanding of the human immune response and the effect of biologic therapy during LPS-induced inflammation.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice

Zhou

Xia

et al. 2019

Molecular Therapy

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Excessive or inappropriate inflammatory responses can cause serious and even fatal diseases. The CCAAT/enhancer-binding protein alpha (CEBPA) gene encodes C/EBPα, a transcription factor that plays a fundamental role in controlling maturation of the myeloid lineage and is also expressed during the late phase of inflammatory responses when signs of inflammation are decreasing. MTL-CEBPA, a small activating RNA targeting for upregulation of C/EBPα, is currently being evaluated in a phase 1b trial for treatment of hepatocellular carcinoma. After dosing, subjects had reduced levels of pro-inflammatory cytokines , and we therefore hypothesized that MTL-CEBPA has anti-inflammatory potential. The current study was conducted to determine the effects of C/EBPα saRNA - CEBPA-51 - on inflammation in vitro and in vivo after endotoxin challenge. CEBPA-51 led to increased expression of the C/EBPα gene and inhibition of pro-inflammatory cytokines in THP-1 monocytes previously stimulated by E. coli -derived lipopolysaccharide (LPS). Treatment with MTL-CEBPA in an LPS-challenged humanized mouse model upregulated C/EBPα mRNA, increased neutrophils, and attenuated production of several key pro-inflammatory cytokines , including TNF-α, IL-6, IL-1β, and IFN - γ. In addition, a Luminex analysis of mouse serum revealed that MTL-CEBPA reduced pro-inflammatory cytokines and increased the anti-inflammatory cytokine IL-10. Collectively, the data support further investigation of MTL-CEBPA in acute and chronic inflammatory diseases where this mechanism has pathogenic importance.

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Anti-inflammatory potential of hentriacontane in LPS stimulated RAW 264.7 cells and mice model

Cited by 39 publications

References 43 publications

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Spasmolytic, Anti-Inflammatory, and Antioxidant Activity of Salvia Gesneriflora Lindley

Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice

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