Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression

Azhary, Khadija El; Jouti, Nadia Tahiri; Khachibi, Meryam El; Moutia, Mouna; Tabyaoui, Imane; Hou, Abdelhalim El; Achtak, Hafid; Nadifi, Sellama; Habti, Norddine; Badou, Abdallah

doi:10.1186/s12906-017-1569-7

Cited by 39 publications

(40 citation statements)

References 40 publications

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“…flavonoids and tannins (Akkari et al, 2016). The anti-inflammatory activity of caper was also detected in animal studies, where leaf extracts were able to reduce edema in treated mice in a dose-dependent manner, as also a significant decrease in immune cells infiltration, vasodilatation and in dermis thickness (Azhary et al, 2017). Furthermore, leaf extracts of the same study inhibited the cytokine gene expression, namely IFNγ, IL-17 and IL-4 (Turgut et al, 2015).…”

Section: Health Effectsmentioning

confidence: 62%

Edible halophytes of the Mediterranean basin: Potential candidates for novel food products

Petropoulos

Karkanis

Martins

et al. 2018

Trends in Food Science & Technology

126

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Background: Recent trends in the food science industry and consumers' preferences for diversified diets suggest the consumption of wild greens not only as diet complements but also as healthy and functional foods for targeted conditions, rendering its commercial cultivation of major importance in order to avoid irrational gathering and genetic erosion threats. The Mediterranean basin abounds in wild edible species which have been used for food and medicinal purposes by human throughout the centuries. Many of these species can be found near coastal areas and usually grow under saline conditions, while others can adapt in various harsh conditions including high salinity. Scope and approach: The aim of this review focuses on listing and describing the most important halophyte species that traditionally have been gathered by rural communities of the Mediterranean basin, while special interest will be given on their chemical composition and health promoting components. Cases of commercially cultivated halophytes will be also presented to highlight their potential as alternative cash crops, while results from in vitro and in vivo health effects will be presented. Key findings and conclusions: The recent literature has provided useful information regarding the potential of wild halophytes as promising ingredients in functional food products and/or as sources of bioactive compounds. However, further research is needed regarding the chemical characterization of these species under commercial cultivation practices, while further clinical and model trials have to be conducted to assess their long term bioactivity and elucidate potential toxic effects and regulations of safe consumption.

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Section: Health Effectsmentioning

confidence: 62%

Edible halophytes of the Mediterranean basin: Potential candidates for novel food products

Petropoulos

Karkanis

Martins

et al. 2018

Trends in Food Science & Technology

126

View full text Add to dashboard Cite

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“…Flavonoids reduce calcium accumulation in cells, which leads to a decrease in the activity of the nitric oxide synthase and phospholipase A2. It has been reported that caper hydroalcoholic extract prevents the expression of inflammatory cytokines such as TNFα, IL1β, IL6, LTB4, superoxide anion, and IL4 (20).…”

Section: Discussionmentioning

confidence: 99%

“…This effect of caper is due to having high levels of quercetin. Caper also has an antioxidant effect and can produce an antinociceptive effect by inhibiting nitric oxide (11,20).…”

Section: Discussionmentioning

confidence: 99%

Pain modulation and Histopathological effects of the Hydroalcoholic extract of Capparis spinosa on mice model of Orofacial formalin test: an experimental study

Rayyani¹,

Seifi²,

Askian³

et al. 2019

Electron. physician

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Background: Orofacial pain is a form of inflammatory pain usually treated with corticosteroids, which have many side effects. Objective: The aim of this study was to investigate the clinical and histological profile of antinociceptive effects of hydroalcoholic extract of caper (Capparis spinosa) for the first time in the orofacial region. Methods: This experimental study was carried out at Babol University of Medical Sciences in 2018. Thirty-six male Wistar mice were divided into 6 groups: The first group received saline, the second group received dexamethazone, and four groups received different doses (10, 20, 50, 100 mg/kg) of caper extract. In the formalin test, 1% formalin solution was injected into the right submucosal layer of the lip and lateral area of the nose. Pain intensities were recorded at 5-min blocks for 60 min after injection. Dose effect of caper on pain was recorded. The mice were euthanized and the oral area was biopsied and stained with Hematoxylin-eosin, Toluidine blue, and Congo red. Data were analyzed using repeated measures ANOVA and t-test by IBM-SPSS version 20. Results: Caper produced antinociceptive effects in comparison with saline groups (p<0.001). Dose effect on pain was significant (p<0.001). The highest antinociceptive effect was observed in the caper group receiving 100 mg/kg of agent 15-20 minutes after injection. The highest pain level was observed in the group that received 20 mg/kg of caper (p<0.001). Dexamethazone antinociceptive effect was greater than that of the saline and the dose of 20 mg/kg of caper (p<0.001). Antinociceptive effects in two groups (100 mg caper and dexamethazone) were equal (p>0.999). Histopathologic examination revealed the highest thickness of epithelium, fibrous, and muscular tissue density and the lowest inflammatory infiltration at the dose of 100 mg/kg of caper. Conclusion:The results of the present study suggest that hydroalcoholic extract of caper possesses antinociceptive activity in a dose-dependent manner and caper-induced antinociception might be mediated, at least in part, by anti-inflammatory effects.

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“…Anti-inflammatory response of human peripheral blood mononuclear cells (PBMCs) induced by C. spinosa leaf extracts results from the control of cytokine gene expression (El Azhary et al, 2017 ). Cytokines constitute a category of small proteins (~5–20 kDa) that are important in cell signaling and inflammatory response.…”

Section: Phytochemical Composition and Activitiesmentioning

confidence: 99%

Capparis spinosa L. in A Systematic Review: A Xerophilous Species of Multi Values and Promising Potentialities for Agrosystems under the Threat of Global Warming

et al. 2017

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Caper (Capparis spinosa L.) is a xerophytic shrub with a remarkable adaptability to harsh environments. This plant species is of great interest for its medicinal/pharmacological properties and its culinary uses. Its phytochemical importance relies on many bioactive components present in different organs and its cultivation can be of considerable economic value. Moreover, taxonomic identification of C. spinosa L. has been difficult due to its wide heterogeneity, and many authors fell into confusion due to the scarcity of genetic studies. The present review summarizes information concerning C. spinosa L. including agronomic performance, botanical description, taxonomical approaches, traditional pharmacological uses, phytochemical evaluation and genetic studies. This knowledge represents an important tool for further research studies and agronomic development on this indigenous species with respect to the emerging climatic change in the Eastern Mediterranean countries. Indeed, this world region is particularly under the threat of global warming and it appears necessary to rethink agricultural systems to adapt them to current and futures challenging environmental conditions. Capparis spinosa L. could be a part of this approach. So, this review presents a state of the art considering caper as a potential interesting crop under arid or semi-arid regions (such as Eastern Mediterranean countries) within the climate change context. The aim is to raise awareness in the scientific community (geneticists, physiologists, ecophysiologists, agronomists, …) about the caper strengths and interest to the development of this shrub as a crop.

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Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression

Cited by 39 publications

References 40 publications

Edible halophytes of the Mediterranean basin: Potential candidates for novel food products

Edible halophytes of the Mediterranean basin: Potential candidates for novel food products

Pain modulation and Histopathological effects of the Hydroalcoholic extract of Capparis spinosa on mice model of Orofacial formalin test: an experimental study

Capparis spinosa L. in A Systematic Review: A Xerophilous Species of Multi Values and Promising Potentialities for Agrosystems under the Threat of Global Warming

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