Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review

Gandhi, Gopalsamy Rajiv; Jothi, Gnanasekaran; Mohana, Thiruchenduran; Vasconcelos, Alan Bruno Silva; Montalvão, Monalisa Martins; Hariharan, Govindasamy; Sridharan, Gopalan; Kumar, Prashant; Gurgel, Ricardo Q; Li, Hua-Bin; Zhang, Jinming; Gan, Ren‐You

doi:10.1016/j.phymed.2021.153766

Cited by 27 publications

(21 citation statements)

References 84 publications

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“…In the Table 1 are presented a few examples of the most referenced compounds in PubMed over the past five years that demonstrate potential antioxidant and anti-inflammatory benefits. It should be taken into account that the list of natural products that demonstrate potential benefits in the management of RA supported by in vitro and animal studies is too extensive to cover exhaustively, and we direct the readers to other reviews on the topic (for review, see REFs [ 274 , 275 , 276 , 277 , 278 ]).…”

Section: Dietary Factors On Mitochondrial Status In Ramentioning

confidence: 99%

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

2022

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Control of excessive mitochondrial oxidative stress could provide new targets for both preventive and therapeutic interventions in the treatment of chronic inflammation or any pathology that develops under an inflammatory scenario, such as rheumatoid arthritis (RA). Increasing evidence has demonstrated the role of mitochondrial alterations in autoimmune diseases mainly due to the interplay between metabolism and innate immunity, but also in the modulation of inflammatory response of resident cells, such as synoviocytes. Thus, mitochondrial dysfunction derived from several danger signals could activate tricarboxylic acid (TCA) disruption, thereby favoring a vicious cycle of oxidative/mitochondrial stress. Mitochondrial dysfunction can act through modulating innate immunity via redox-sensitive inflammatory pathways or direct activation of the inflammasome. Besides, mitochondria also have a central role in regulating cell death, which is deeply altered in RA. Additionally, multiple evidence suggests that pathological processes in RA can be shaped by epigenetic mechanisms and that in turn, mitochondria are involved in epigenetic regulation. Finally, we will discuss about the involvement of some dietary components in the onset and progression of RA.

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Section: Dietary Factors On Mitochondrial Status In Ramentioning

confidence: 99%

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

2022

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“…Cytokines are chemical messengers in the body that are secreted by the immune system and can influence communication between cells [ 11 ]. Cytokines including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1B, IL-6, IL-17, and IL-18, as well as inflammatory markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) that have been used in diagnosing and tracking the progression of RA [ 11 - 12 ]. In many immune reactions and disease processes, TNF-α, IL-6, and IL-1B increase inflammation and leukocyte recruitment, while counter-regulatory cytokines IL-4 and IL-10 decrease inflammation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cytokines including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1B, IL-6, IL-17, and IL-18, as well as inflammatory markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) that have been used in diagnosing and tracking the progression of RA [ 11 - 12 ]. In many immune reactions and disease processes, TNF-α, IL-6, and IL-1B increase inflammation and leukocyte recruitment, while counter-regulatory cytokines IL-4 and IL-10 decrease inflammation [ 11 ]. Dysregulation and imbalance of these systems is the mechanism behind the autoimmune dysfunction seen in RA [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…In many immune reactions and disease processes, TNF-α, IL-6, and IL-1B increase inflammation and leukocyte recruitment, while counter-regulatory cytokines IL-4 and IL-10 decrease inflammation [ 11 ]. Dysregulation and imbalance of these systems is the mechanism behind the autoimmune dysfunction seen in RA [ 11 ]. Activated macrophages in the joint tissues of RA patients secrete various pro-inflammatory cytokines [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dysregulation and imbalance of these systems is the mechanism behind the autoimmune dysfunction seen in RA [ 11 ]. Activated macrophages in the joint tissues of RA patients secrete various pro-inflammatory cytokines [ 11 , 13 ]. TNF-α activates fibroblasts and IL-1B causes fibroblast proliferation [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Nutritional Interventions on Key Cytokine Pathways in Rheumatoid Arthritis and Its Implications for Comorbid Depression: Is a More Comprehensive Approach Required?

Lanspa¹,

Kothe²,

Pereira³

et al. 2022

Cureus

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Rheumatoid arthritis (RA) is associated with both local and systemic inflammatory processes via the aberrant regulation of inflammatory pathways and imbalances in several mediators of inflammation. Cytokines, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1B, IL-6, IL-17, IL-18, rheumatoid factor, anti-cyclic citrullinated protein, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) have been used in diagnosing and tracking the progression of RA. The primary objective of this review is to identify and summarize which specific dietary patterns and nutritional interventions go beyond symptom management to improve the response to known inflammatory cytokines and possibly decrease markers of inflammation in the RA disease process. Analysis of the 41 identified publications demonstrated that certain dietary patterns, the consumption of specific macronutrients, and supplementation with herbals or other compounds have shown some effect on improving cytokine profiles in patients with RA. This review illustrates the importance of proper patient education on the anti-inflammatory and potential protective impacts substantial dietary change may have on the disease progression and symptoms of RA. Identifying nutritional interventions and dietary patterns that improve the inflammatory cytokine profile, and therefore disease progression and inflammatory comorbidities of RA will help further focus research on treatments that may provide a better overall improvement in quality of life for RA patients by focusing on the root cause inflammatory processes that affect not only joint destruction but also depression-rated disability. This review further notes that while depression is commonly found in patients who suffer from chronic illnesses, it is especially prevalent in the RA population. The pathology of depression is associated with systemic inflammation, which is a known outcome of RA and may explain this strong association. Cytokines IL-6, IL-1, and TNF-α, known mediators involved in the progression of RA, are strongly associated with stress-related disorders including depression and anxiety. The presence of these cytokines is also correlated with the severity and duration of depression. This may signal a potential use of cytokines in diagnosing and following the progression of depression not only in patients with RA but also others. Given the statistics presented on depression and suicide in patients with RA, and the shared inflammatory pathway between the two diseases, depression and suicide screening scales should be included along with analysis of inflammatory markers and disease activity scores (DAS) in any future RA study.

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Critical appraisal tools used in systematic reviews of in vitro cell culture studies: A methodological study

Barbosa

Silveira

Santos

et al. 2023

Research Synthesis Methods

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Systematic reviews (SRs) of preclinical studies are marked with poor methodological quality. In vitro studies lack assessment tools to improve the quality of preclinical research. This methodological study aimed to identify, collect, and analyze SRs based on cell culture studies to highlight the current appraisal tools utilized to support the development of a validated critical appraisal tool for cell culture in vitro research. SRs, scoping reviews, and meta‐analyses that included cell culture studies and used any type of critical appraisal tool were included. Electronic search, study selection, data collection and methodological quality (MQ) assessment tool were realized. Further, statistical analyses regarding possible associations and correlations between MQ and collected data were performed. After the screening process, 82 studies remained for subsequent analysis. A total of 32 different appraisal tools were identified. Approximately 60% of studies adopted pre‐structured tools not designed for cell culture studies. The most frequent instruments were SYRCLE (n = 14), OHAT (n = 9), Cochrane Collaboration's tool (n = 7), GRADE (n = 6), CONSORT (n = 5), and ToxRTool (n = 5). The studies were divided into subgroups to perform statistical analyses. A significant association (OR = 5.00, 95% CI = 1.54–16.20, p = 0.008) was found between low MQ and chronic degenerative disorders as topic of SR. Several challenges in collecting information from the included studies led to some modifications related to the previously registered protocol. These results may serve as a basis for further development of a critical appraisal tool for cell culture studies capable of capturing all the essential factors related to preclinical research, therefore enhancing the practice of evidence‐based.

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Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review

Cited by 27 publications

References 84 publications

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

A Systematic Review of Nutritional Interventions on Key Cytokine Pathways in Rheumatoid Arthritis and Its Implications for Comorbid Depression: Is a More Comprehensive Approach Required?

Critical appraisal tools used in systematic reviews of in vitro cell culture studies: A methodological study

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