Anti-inflammatory medications for obstructive sleep apnoea in children

Abstract

Anti-inflammatory medications for obstructive sleep apnoea in children (Review)

Effectiveness of Adenotonsillectomy vs Watchful Waiting in Young Children With Mild to Moderate Obstructive Sleep Apnea

“…Children seem to return faster to normal activity after tonsillotomy compared to tonsillectomy; nevertheless, the long-term effect and need for repeated surgery is still uncertain 133 . Children with non-severe OSA who receive intranasal steroids and leukotriene antagonists have shown improvement in their PSG parameters as well as their QoL [134][135][136] . CPAP is not a common treatment in Sweden for children with OSA, but it can be an option for children with persistent OSA after surgery or when surgery is not recommended (e.g.…”

Treatment of Obstructive Sleep Apnea in Children: Handling the Unknown with Precision

“…Two RCTs have been conducted to date and have shown the favorable response to montelukast as a single agent in the treatment of pediatric OSA [71,72]. In a recent systematic review that included several different studies, significant improvements in the degree of respiratory disturbance and in the severity of hypoxemia emerged with montelukast monotherapy [73,74]. Interestingly, after a 12-week trial with either corticosteroids or oral montelukast, similar reductions in apnea-hypopnea index emerged in patients with mild OSA [75].…”

“…Based on the favorable responses to either intranasal corticosteroids or montelukast, combinatorial therapy has been proposed and thus far has resulted in rather favorable outcomes, both in terms of improvements in the severity of OSA in a large retrospective study that included 752 children [78], as well as in their quality of life [79]. In addition, combined used of nasal corticosteroids and oral montelukast appear to exhibit superior efficacy when compared to either one separately [74]. However, some children may be more likely to derive benefit from this approach than others.…”

Diagnosis and management of childhood sleep-disordered breathing

“…108 Parents should be aware of recent concern on neuropsychiatric event in children with the use of montelukast, the data come from asthmatic patients but to be mentioned and observed. 106,109,110 Combination therapy. The combination of inhaled steroids and antileukotiene for 3 months were effective in several papers.…”