Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer

Kariagina, Anastasia; Doseff, Andrea I.

doi:10.3390/ijms232415753

Cited by 16 publications

(11 citation statements)

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“…Although we did not initially focus on inflammatory biomarkers such as ferritin in our study, in future research on the inflammation associated with NASH, we can consider measuring inflammatory biomarkers like ferritin in the serum of patients with NAFLD or NASH. Differences in various carbohydrate metabolisms also indicate changes in the fundamental metabolism between the two groups ( Sandoval et al, 2020 ; Kariagina and Doseff, 2022 ; Tan et al, 2022 ). This finding provides support for the hypothesis that NAFLD is fundamentally a metabolic disorder.…”

Section: Discussionmentioning

confidence: 99%

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

Huang,

Lyu,

Xie

et al. 2024

Front. Microbiol.

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Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized for its global prevalence and potential progression to more severe liver diseases such as non-alcoholic steatohepatitis (NASH). The gut microbiota plays a pivotal role in the pathogenesis of NAFLD, yet the detailed characteristics and ecological alterations of gut microbial communities during the progression from non-alcoholic fatty liver (NAFL) to NASH remain poorly understood. Methods: In this study, we conducted a comparative analysis of gut microbiota composition in individuals with NAFL and NASH to elucidate differences and characteristics. We utilized 16S rRNA sequencing to compare the intestinal gut microbiota among a healthy control group (65 cases), NAFL group (64 cases), and NASH group (53 cases). Random forest machine learning and database validation methods were employed to analyze the data. Results: Our findings indicate a significant decrease in the diversity of intestinal flora during the progression of NAFLD (p < 0.05). At the phylum level, high abundances of Bacteroidetes and Fusobacteria were observed in both NAFL and NASH patients, whereas Firmicutes were less abundant. At the genus level, a significant decrease in Prevotella expression was seen in the NAFL group (AUC 0.738), whereas an increase in the combination of Megamonas and Fusobacterium was noted in the NASH group (AUC 0.769). Furthermore, KEGG pathway analysis highlighted significant disturbances in various types of glucose metabolism pathways in the NASH group compared to the NAFL group, as well as notably compromised flavonoid and flavonol biosynthesis functions. The study uncovers distinct microbiota characteristics and microecological changes within the gut during the transition from NAFL to NASH, providing insights that could facilitate the discovery of novel biomarkers and therapeutic targets for NAFLD.

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Section: Discussionmentioning

confidence: 99%

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

Huang,

Lyu,

Xie

et al. 2024

Front. Microbiol.

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“…Natural flavones such as apigenin and nobiletin can regulate the expression of important inflammatory signaling pathways, including nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). The antioxidant properties of several natural flavones are attributable to their ability to regulate the expression of Nrf2/heme oxygenase-1 (HO-1), which decreases free radical levels and oxidative stress [ 13 ]. Nuclear factor erythroid 2-related factor (Nrf2) can interact with the NF-κB signaling pathway to maintain cellular redox homeostasis during inflammatory states.…”

Section: Biological Activity Of Flavones Flavonols and Auronesmentioning

confidence: 99%

Flavones and Related Compounds: Synthesis and Biological Activity

Leonte,

Ungureanu,

Zaharia

2023

Molecules

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This review focuses on the synthesis and biological activity of flavones and their related flavonoidic compounds, namely flavonols and aurones. Among the biological activities of natural and synthetic flavones and aurones, their anticancer, antioxidant, and antimicrobial properties are highlighted and detailed in this review. Starting from the structures of natural flavones acting on multiple anticancer targets (myricetin, genkwanin, and other structurally related compounds), new flavone analogs were recently designed and evaluated for their anticancer activity. The most representative compounds and their anticancer activity are summarized in this review. Natural flavones recognized for their antimicrobial properties (baicalein, luteolin, quercetol, apigenin, kaempferol, tricin) have been recently derivatized or structurally modulated by chemical synthetic methods in order to obtain new effective antimicrobial flavonoidic derivatives with improved biological properties. The most promising antimicrobial agents are systematically highlighted in this review. The most applied method for the synthesis of flavones and aurones is based on the oxidative cyclization of o-hydroxychalcones. Depending on the reaction conditions and the structure of the precursor, in some cases, several cyclization products result simultaneously: flavones, flavanones, flavonols, and aurones. Based on the literature data and the results obtained by our research group, our aim is to highlight the most promising methods for the synthesis of flavones, as well as the synthetic routes for the other structurally related cyclization products, such as hydroxyflavones and aurones, while considering that, in practice, it is difficult to predict which is the main or exclusive cyclization product of o-hydroxychalcones under certain reaction conditions.

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“…Flavones are typically present in food as glycosides. The absorption of orally delivered apigenin has been the subject of animal studies, particularly in rats [ 108 ]. Most of these studies show that apigenin aglycones and O-glycosides are absorbed quickly: the Tmax is generally ≤ 1 h, with a Cmax of 1–100 mmol/L, depending on the dose and the food matrix [ 109 ].…”

Section: Critical Aspects Of Apigenin For Therapeutic Purposesmentioning

confidence: 99%

Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction

Fossatelli,

Maroccia,

Fiorentini

et al. 2023

IJMS

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Apigenin is one of the most widespread flavonoids in the plant kingdom. For centuries, apigenin-containing plant preparations have been used in traditional medicines to treat diseases that have an inflammatory and/or degenerative component. In the 1980s, apigenin was proposed to interfere with the process of carcinogenesis. Since then, more and more evidence has demonstrated its anticancer efficacy, both in vitro and in vivo. Apigenin has been shown to target signaling pathways involved in the development and progression of cancer, such as PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, NF-κB, and Wnt/β-catenin pathways, and to modulate different hallmarks of cancer, such as cell proliferation, metastasis, apoptosis, invasion, and cell migration. Furthermore, apigenin modulates PD1/PD-L1 expression in cancer/T killer cells and regulates the percentage of T killer and T regulatory cells. Recently, apigenin has been studied for its synergic and additive effects when combined with chemotherapy, minimizing the side effects. Unfortunately, its low bioavailability and high permeability limit its therapeutic applications. Based on micro- and nanoformulations that enhance the physical stability and drug-loading capacity of apigenin and increase the bioavailability of apigenin, novel drug-delivery systems have been investigated to improve its solubility.

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Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer

Cited by 16 publications

References 235 publications

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

Flavones and Related Compounds: Synthesis and Biological Activity

Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction

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