Anti-inflammatory mechanism of the optimized active ingredients of Sargentodoxa cuneata and Patrinia villosa

Liu, Xiaoqin; Shao, Puwei; Wang, Ying; Chen, Yuanyuan; Cui, Shuna

doi:10.1016/j.intimp.2023.110337

Cited by 1 publication

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“…The combination of flavonoids, anthraquinones, and aporphine alkaloids can lead to robust anti-inflammatory effects. For example, the combination of the anthraquinone emodin or sinoacutine with the flavonoid acacetin has been recently shown to exert potent anti-inflammatory effects that are superior to those of the individual components [ 97 ]. Comparable effects may occur when using an extract of F. oldhamii , which also contains similar flavonoids and anthraquinones, notably sinoacutine (salutaridine, 55 ) [ 14 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

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The species Fissistigma oldhamii (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic syndromes, sciatica, and osteoarthritis. The phytochemical content of the plant and the associated pharmacological activities have been analyzed. Seventy natural products were identified in the different parts of the plants, namely, the roots, stems, leaves, fruits, and seeds. The compounds comprise many tri- and tetracyclic alkaloids (aporphine-type), anthraquinones, terpenoids, flavonoids, and others. The pharmacological properties of these molecules were analyzed to point out the anti-inflammatory, antioxidant, anticancer, and/or antimicrobial effects, together with the underlying modulated pathways and molecular targets in some cases. The panel of phytoconstituents present in F. oldhamii extracts is large, with the majority of bioactive products identified in the roots and stems. Multiple molecules can contribute to the anti-inflammatory properties of the extracts. Network pharmacology analyses of the phytoconstituents are needed to better delineate the effective components and their targets.

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Section: Discussionmentioning

confidence: 99%

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

View full text Add to dashboard Cite

show abstract

Anti-inflammatory mechanism of the optimized active ingredients of Sargentodoxa cuneata and Patrinia villosa

Cited by 1 publication

References 43 publications

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

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