Anti-inflammatory/infection PLA nanoparticles labeled with technetium 99m for in vivo imaging

Santos, Sofia Nascimento dos; Reis, Sara Rhaissa Rezende dos; Pinto, Suyene Rocha; Cerqueira-Coutinho, Cristal; Nigro, Fiammetta; Barja-Fidalgo, Thereza Christina; Pinheiro, Nathalia Martins Alexandre; Neto, Heitor A. Paula; Santos-Oliveira, Ralph

doi:10.1007/s11051-017-4037-x

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…Dos Santos et al (2017) synthesized PLA nanoparticles loaded with betamethasone and dexamethasone (antiflammatory drugs) and labeled with technetium-99m. Experiments showed that betamethasone loaded particles were able to accumulate in the inflammation site in an in vivo model of S. aureus infection.…”

Section: The New Paradigm Introduced By Nanoparticlesmentioning

confidence: 99%

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Casalini

Rossi

Castrovinci

et al. 2019

Front. Bioeng. Biotechnol.

315

181

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Polylactic acid (PLA)—based polymers are ubiquitous in the biomedical field thanks to their combination of attractive peculiarities: biocompatibility (degradation products do not elicit critical responses and are easily metabolized by the body), hydrolytic degradation in situ, tailorable properties, and well-established processing technologies. This led to the development of several applications, such as bone fixation screws, bioresorbable suture threads, and stent coating, just to name a few. Nanomedicine could not be unconcerned by PLA-based materials as well, where their use for the synthesis of nanocarriers for the targeted delivery of hydrophobic drugs emerged as a new promising application. The purpose of the here presented review is two-fold: on one side, it aims at providing a broad overview of PLA-based materials and their properties, which allow them gaining a leading role in the biomedical field; on the other side, it offers a specific focus on their recent use in nanomedicine, highlighting opportunities and perspectives.

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Section: The New Paradigm Introduced By Nanoparticlesmentioning

confidence: 99%

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Casalini

Rossi

Castrovinci

et al. 2019

Front. Bioeng. Biotechnol.

315

181

View full text Add to dashboard Cite

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“…Like any radioactive modality, concerns about risks are always relevant but data in the literature corroborate that the benefits of using radioactive material outweighs its risks (Kunjachan et al., 2015 ; Simonetti et al., 2019 ). Similarly, imaging modalities like CT procedures that may induce DNA damage are used when the benefits outweigh the risks (Dos Santos et al., 2017 ; Helal-Neto et al., 2019 ; Basheerudeen et al., 2017 ; International Society for Pharmacoeconomics and Outcomes Research Rare Disease Special Interest Group, 2015 ). The use of radioactive polymeric nanoparticles may also improve efficacy, leading to a higher targeting in tissues/organs (Bolzati et al., 2012 ; Banerjee et al., 2017 ), which decreases the dose used (including the radioactive dose) and consequently reduces the risk.…”

Section: Discussionmentioning

confidence: 99%

“…Santos et al evaluated betamethasone and dexamethasone PLA (Poly-lactic acid) NPs labeled with 99m Tc in Staphylococcus aureus infection/ inflammation in vivo model. They verified that 99m Tc-PLA NPs containing betamethasone showed accumulation at S. aureus inflammation site indicating that this system can be used for infection/inflammation foci during in vivo detection (Dos Santos et al, 2017). Another example from Helal-Neto et al described the development of an ethambutol NP using PCL (poly-caprolactone) as a polymer and radiolabeled with 99m Tc.…”

Section: Infectious Diseasesmentioning

confidence: 95%

“…Polymeric nanoparticulate systems are reported as excellent diagnostic, therapeutic, and theranostic precursor agents. These systems are used for studies in numerous diseases such as ischemia, cardiovascular diseases (Hwang et al., 2014 ), angiogenesis (Almutairi et al., 2009 ), atherosclerosis (Delgado et al., 2000 ; Subramanian et al., 2010 ; Stendahl and Sinusas, 2015 ; Wang et al., 2017 ), inflammation, cancer (Delgado et al., 2000 ; Subramanian et al., 2010 ; Criscione et al., 2011 ; Liu et al., 2011 ; Wang et al., 2017 ), and infectious diseases (Delgado et al., 2000 ; Subramanian et al., 2010 ; Criscione et al., 2011 ; Liu et al., 2011 ; Seo et al., 2014 ; Aweda et al., 2015 ; Fairclough et al., 2016 ; Woodard et al., 2016 ; Dos Santos et al., 2017 ; Tu et al., 2018 ; Simonetti et al., 2019 ), among others. The radiolabeled NPs decorated or functionalized with amino acids, simple peptides, or dendrimers promote targeting to improve uptake, biocompatibility, and stability.…”

Section: Radioactive Polymeric Nanoparticles For Biomedical Applicatimentioning

confidence: 99%

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Radioactive polymeric nanoparticles for biomedical application

Wu¹,

Helal-Neto

Matos

et al. 2020

Drug Delivery

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Nowadays, emerging radiolabeled nanosystems are revolutionizing medicine in terms of diagnostics, treatment, and theranostics. These radionuclides include polymeric nanoparticles (NPs), liposomal carriers, dendrimers, magnetic iron oxide NPs, silica NPs, carbon nanotubes, and inorganic metal-based nanoformulations. Between these nano-platforms, polymeric NPs have gained attention in the biomedical field due to their excellent properties, such as their surface to mass ratio, quantum properties, biodegradability, low toxicity, and ability to absorb and carry other molecules. In addition, NPs are capable of carrying high payloads of radionuclides which can be used for diagnostic, treatment, and theranostics depending on the radioactive material linked. The radiolabeling process of nanoparticles can be performed by direct or indirect labeling process. In both cases, the most appropriate must be selected in order to keep the targeting properties as preserved as possible. In addition, radionuclide therapy has the advantage of delivering a highly concentrated absorbed dose to the targeted tissue while sparing the surrounding healthy tissues. Said another way, radioactive polymeric NPs represent a promising prospect in the treatment and diagnostics of cardiovascular diseases such as cardiac ischemia, infectious diseases such as tuberculosis, and other type of cancer cells or tumors.

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“…Nas áreas médica e farmacêutica, estudos relacionados à eficácia de nanorradiofármacos têm sido realizados com o intuito de aprimorar as técnicas de diagnóstico e terapia nos serviços de medicina nuclear resultando no desenvolvimento de diferentes nanopartículas [1]. Atualmente, os polímeros mais utilizados na área farmacêutica são poli (ácido D, L-láctico-co-glicólico) (PLGA), poli (ácido láctico) (PLA), poli (ácido glutâmico) (PGA), poli (caprolactona) (PCL), copolímeros de N-(2hidroxipropil)-metacrilato (HPMA), polissacarídeos e poli (aminoácidos) [2][3][4]. As nanopartículas poliméricas biodegradáveis têm sido frequentemente utilizadas para aumentar a eficácia terapêutica de diversos fármacos solúveis / insolúveis em água e moléculas bioativas, uma vez que aprimoram sua biodisponibilidade, solubilidade e tempo de retenção tanto no diagnóstico quanto no tratamento de câncer [5].…”

Section: Introductionunclassified

Avaliação em microcosmo da influência de nanopartículas (hidroxiapatita e PLGA) sobre o comportamento químico de Zn, Cu e Mn em sistema costeiro degradado

et al. 2019

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A liberação de diversos tipos de nanopartículas no ambiente aquático pode resultar na exposição direta ou indireta do homem e de organismos aquáticos, ou impactos no comportamento de metais. A ausência de legislação ambiental específica para o descarte de rejeitos oriundos de atividades que utilizam nanopartículas, como centros de pesquisa, serviços de medicina nuclear e a indústria, tem contribuído para a liberação descontrolada desses materiais no meio ambiente tornando-os relevantes dentro do contexto ecotoxicológico. Neste estudo, o impacto de nanopartículas com uso promissor pela medicina nuclear (nanohidroxiapatita e ácido D, L-láctico-co-glicólico -PLGA) sobre o comportamento químico de metais, foi avaliado através de ensaios em microcosmos, estruturados com as condições do Canal do Cunha (RJ). Este canal é parte de um sistema aquático costeiro, impactado por rejeitos industriais, domésticos e hospitalar, com elevados teores em metais e materiais orgânicos, já reportados na literatura. Ao contrário de estudo prévio realizado com condições operacionais semelhantes ao presente estudo, porém estruturado com materiais de sistema aquático pouco impactado por esses rejeitos, este estudo não identificou modificações no comportamento de metais dissolvidos (Cu, Zn e Mn), após a introdução dos nanomateriais, devido ao elevado grau de degradação orgânica do sistema. O estudo atual corrobora a influência de compostos orgânicos no efeito do aporte de nanomateriais em ambientes aquáticos.Palavras-chave: nanopartículas, ambiente aquático poluído, ensaio em microcosmo

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Anti-inflammatory/infection PLA nanoparticles labeled with technetium 99m for in vivo imaging

Cited by 10 publications

References 26 publications

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Radioactive polymeric nanoparticles for biomedical application

Avaliação em microcosmo da influência de nanopartículas (hidroxiapatita e PLGA) sobre o comportamento químico de Zn, Cu e Mn em sistema costeiro degradado

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