Anti-inflammatory, hypoglycemic, hypolipidemic, and analgesic activities of Plinia cauliflora (Mart.) Kausel (Brazilian grape) epicarp

Brito, Thaise Gabriele da Silva; Silva, Ana Paula Sant'Anna da; Cunha, Rebeca Xavier da; Fonseca, Caíque Silveira Martins da; Araújo, Tiago Ferreira da Silva; Campos, Janaína Karin de Lima; Nascimento, Weber Melo; Araújo, Hallysson Douglas Andrade de; Silva, Joanda Paolla Raimundo e; Tavares, Josean Fechine; Santos, Bianka Santana dos; Lima, Vera Lúcia de Menezes

doi:10.1016/j.jep.2020.113611

Cited by 14 publications

(11 citation statements)

References 92 publications

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“…The concentrated liquid extract from jabuticaba residues did not alter the plasmatic levels of triglycerides, total cholesterol, and HDL-cholesterol in Chinese hamsters with a regular diet or a cholesterol-enriched diet (Figures 2, 3). In opposite to what was observed in this study, previous studies showed a reduction in serum cholesterol and triglycerides and an increase in HDL-cholesterol of rats and mice fed with jabuticaba peel (Lenquiste et al, 2012;Araújo et al, 2014;Brito et al, 2021;Batista et al, 2018). These advantages over serum biochemical markers could be explained by anthocyanins' presence (Kong et al, 2003), which may have been extracted during the fermentation process to obtain the jabuticaba beverage.…”

Section: Biochemical Parameterscontrasting

confidence: 99%

“…After 45 days of feeding, the animals were anesthetized (isoflurane inhalation), and blood was gastrointestinal and cardiovascular disturbances (Giraldi and Hanazaki, 2010;Borges et al, 2014). Jabuticaba peels present antioxidant, anti-inflammatory, and analgesic effects, reduced blood cholesterol and obesity-associated insulin resistance, improved glucose levels and lipid markers, and reduced adipose tissue inflammation, weight gain, dyslipidemia, and hepatic steatosis in animal models (Dragano et al, 2013;Araújo et al, 2014;Lenquiste et al, 2015;Batista et al, 2018;Brito et al, 2021).…”

Section: Animals and Dietsmentioning

confidence: 99%

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Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters

et al. 2023

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Plinia cauliflora (Mart.) Kausel, popularly known as jabuticaba, is rich in polyphenols. Phenolic compounds exhibit several biological properties, which reflect on biomarkers such as biochemical parameters. In the present study, we evaluated the plasmatic levels of glucose, total cholesterol, HDL-cholesterol, triglycerides, and uric acid of Chinese hamsters fed for 45 days with a regular diet or cholesterol-enriched diet supplemented with a liquid extract obtained from P. cauliflora fruits residues standardized in ellagic acid and total phenolic compounds. The results showed that the concentrated extract obtained from jabuticaba residues increased the glycemia of animals fed with a regular diet and reduced the plasmatic uric acid levels of animals fed with a cholesterol-enriched diet. Since hyperuricemia is considered to be a significant risk factor of metabolic disorders and the principal pathological basis of gout, the liquid extract from P. cauliflora fruits residues would be a promising candidate as a novel hypouricaemic agent for further investigation.

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Section: Biochemical Parameterscontrasting

confidence: 99%

Section: Animals and Dietsmentioning

confidence: 99%

Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters

et al. 2023

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“…It has been demonstrated that phenols like ellagic acid have a central analgesic effect that may act through the opioid system. 42 …”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that phenols like ellagic acid have a central analgesic effect that may act through the opioid system. 42 In the current study, carrageenan-induced paw edema for acute inflammation and cotton pellet-induced granuloma for chronic inflammation were used as models to assess the anti-inflammatory effects of plant extract and solvent fractions. Carrageenan is a phlogistic, non-antigenic substance and is without obvious systemic effect.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Activities of 80% Methanol Extract and Solvent Fractions of Ehretia cymosa Thonn (Boraginaceae) Leaves in Rodents

Ashagrie¹,

Abebe²,

Umer³

2023

JEP

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Background Ethnobotanical studies in various districts of Ethiopia reported that Ehretia cymosa ( E. cymosa ) is used for the management of headache, abdominal pain, arthritis and rheumatism. However, there is no scientific investigation done so far to confirm these traditional claims. Thus, the aim of this study was to assess the analgesic and anti-inflammatory effects of the 80% methanol extract and fractions of E. cymosa leaves. Methods The dried and pulverized leaves of E. cymosa were soaked with 80% methanol to obtain a crude extract. Fractionation was done using chloroform, ethyl acetate and water by a soxhlet apparatus. The analgesic effects of the crude extract and solvent fractions were assessed using acetic acid-induced writhing and hot plate tests whereas anti-inflammatory activities were investigated using carrageenan-induced paw edema and cotton-pellet-induced granuloma models. Results In all the tested doses, the 80% methanol extract and solvent fractions revealed substantial (p < 0.001) analgesic activities in acetic acid induced writhing test. In the hot plate method, all the tested doses of E. cymosa crude extract and the solvent fractions produced significant analgesic activities (p < 0.05). In the carrageenan-induced acute inflammation model, all tested doses of the crude extract and solvent fractions resulted in a significant decline in paw edema. The 80% methanol extract and solvent fractions of E. cymosa at all the tested doses significantly reduced inflammatory exudates and granuloma mass formations (p < 0.001). Conclusion From the results of this investigation, it can be stated that 80% methanol extract, aqueous, ethyl acetate and chloroform fractions of E. cymosa exhibited considerable analgesic and anti-inflammatory activities, supporting the plant’s traditional use as a remedy for a variety of painful and inflammatory conditions.

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“…Therefore, it is necessary to develop alternatives. It has been reported that mulberry, soybean, grape seed, dandelion, persimmon leaf, ginkgo leaf, balsam pear, and other plant extracts are nontoxic and have positive effects in patients with T2DM (Brito et al., 2020; Chen et al., 2020; Li et al., 2019; Lim et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

The hypoglycemic effect of freeze‐dried fermented mulberry mixed with soybean on type 2 diabetes mellitus

Long

Pang

et al. 2021

Food Science & Nutrition

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Mulberry has significant hypoglycemic effect and can be used as an auxiliary food for people with type 2 diabetes. However, it is rich in carbohydrate and cannot be consumed directly by diabetic patients. In the study, we fermented the mulberry to reduce the content of glucose and fructose, and added the soybean to reduce the loss of probiotics during fermentation and then determined its hypoglycemic effect. We induced type 2 diabetes mellitus (T2DM) mice by streptozotocin and measured its blood glucose, serum biochemistry, hepatic and pancreatic histopathology, and the diversity of the gut microbiota. After 5 weeks of oral DFMS administration, the glucose tolerance was improved significantly in T2DM mice. Furthermore, there were also significant increases in superoxide dismutase activity and glutathione concentration, and marked reductions in the concentrations of malondialdehyde and free fatty acids. Moreover, DFMS also prevented histopathological changes and the increases in the activities of alanine transaminase and aspartate transaminase. DFMS treatment also markedly increased the richness of the gut microbial community. The abundance of Bacteroidetes was increased, and those of Proteobacteria, Escherichia‐Shigella, and Lactobacillus were reduced. In summary, DFMS has a clear hypoglycemic effect in mice with T2DM.

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Anti-inflammatory, hypoglycemic, hypolipidemic, and analgesic activities of Plinia cauliflora (Mart.) Kausel (Brazilian grape) epicarp

Cited by 14 publications

References 92 publications

Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters

Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters

Analgesic and Anti-Inflammatory Activities of 80% Methanol Extract and Solvent Fractions of Ehretia cymosa Thonn (Boraginaceae) Leaves in Rodents

The hypoglycemic effect of freeze‐dried fermented mulberry mixed with soybean on type 2 diabetes mellitus

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