Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway

Gao, Yan; Chu, Shifeng; Li, Jingwei; Li, Jianping; Zhao, Zi‐Gang; Xia, Changfa; Heng, Yang; Zhang, Meijin; Hu, Jin‐Feng; Wei, Guining; Li, Yueting; Chen, Nai‐Hong

doi:10.1016/j.jep.2015.07.020

Cited by 78 publications

(46 citation statements)

References 62 publications

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“…Among these compounds, ginsenoside Rb1 (22) (27), ginsenoside Rh2 (37), and ginsenoside Rh3 (38). There are reports for anti-inflammatory properties of notoginseng saponins, bile acids, taurine, and muscone [20][21][22][23][24][25][26] and hence, these components present in PZH are responsible for anti-inflammatory activity of PZH.…”

Section: Anti-inflammatory Activity Evaluation Of Compoundsmentioning

confidence: 99%

Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry

Huang

Zhang

et al. 2016

Journal of Chromatography B

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Section: Anti-inflammatory Activity Evaluation Of Compoundsmentioning

confidence: 99%

Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry

Huang

Zhang

et al. 2016

Journal of Chromatography B

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“…Previously, many researchers have reported that antioxidant stress (imbalance between antioxidant and free radical generation) is one the key factor that contributes to psoriasis and hence various antioxidant supplements are recommended for psoriasis patients (Lin & Huang, ; Raut & Wairkar, ). The levels of antioxidant (SOD/CAT) were significantly decreased with elevated lipid peroxidation product (MDA) were noted in IMQ exposed psoriasis model mice, but on treatment with GRg1 those antioxidant and MDA levels were normalized attributing to free radical scavenging and anti‐lipid peroxidation activities (Gao et al, ; Xin et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, we would like to explore whether GRg1 exhibit anti‐inflammatory activity via regulating the NF‐κB signaling pathway. Since copious studies have indicated that GRg1 display potent anti‐inflammatory property through inhibiting nuclear factor‐kappa B (NF‐κB) signaling pathway in various cell line and animal model (Gao et al, ; Sun et al, ; Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…GRg1 exhibit a broad range of pharmacological activities including antioxidant, antiproliferative, immunomodulatory, antimicrobial, antitumor, and anti‐infertility (Gao, Chu, Zhang, & Chen, ; Tian et al, ). Many authors have previously indicated that ginsenoside Rg1 could display potent anti‐inflammatory property through inhibiting nuclear factor‐kappa B (NF‐κB) signaling pathway in various cell line and animal model (Gao et al, ; Sun et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

Shi

Chen

et al. 2019

J Food Biochem

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This animal experiment was framed to evaluate the beneficial effect of ginsenoside Rg1 (GRg1) against imiquimod (IMQ)‐induced psoriasis‐like dermatitis model to reveal the underpinning mechanism. Fifty healthy BALB/c mice were divided into five groups as control, GRg1, IMQ induced, oral treatment of GRg1 (50 mg/kg), or dexamethasone (DXM; 10 mg/kg) in IMQ‐induced mice. Treatment with GRg1 or DXM significantly mitigates (p < .01) psoriasis area severity index (PASI) score, skin thickness, lipid peroxidation, and inflammatory markers (IL‐23, 22, 17A, 1β, and TNF‐α). Moreover, administration of GRg1 or DXM considerably reversed the morphological changes induced by IMQ with improved (p < .01) antioxidant activity (SOD, CAT). In addition, a marked downregulation (p < .01) of protein expressions of pIκB and NF‐κB p65 (NF‐κB signaling pathway) were noted in GRg1 group. Collectively, GRg1 or DXM treatment significantly abolishes IMQ‐induced psoriasis‐like dermatitis by lowering PASI score, inflammation through downregulating NF‐κB signaling pathway. Practical applications This is the very first study to explore the efficacy of ginsenoside Rg1 (GRg1) against IMQ‐induced psoriasis in the mice model to reveal the underpinning mechanism. The results clearly showed that GRg1 potent anti‐psoriasis activity by lowering PASI score, inflammation through downregulating NF‐κB signaling pathway. Hence, this study helps in the development of novel nutraceutical/functional food against psoriasis and thus could improve the quality of life in psoriasis patients. However, further clinical trials are needed to justify the above results before developing a commercial functional food using GRg1 against psoriasis.

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“…The relationship between Rg1 and GR has been extensively studied, such as anti-inflammatory function of Rg1, antiapoptosis, and neural differentiation and so on. [39][40][41] Therefore, the unwanted effects of Rg1 should be concerned, especially osteoporosis. However, work from Du study has clearly indicated that Rg1 effectively inhibits acute and chronic inflammation in vivo, while it does not cause hyperglycemia or osteoporosis as seen with dexamethasone.…”

Section: )mentioning

confidence: 99%

Protective Effect of Ginsenoside Rg1 on Bleomycin-Induced Pulmonary Fibrosis in Rats: Involvement of Caveolin-1 and TGF-β1 Signal Pathway

Zhan

Huang

et al. 2016

Biological & Pharmaceutical Bulletin

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Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and high mortality rate. Panax Notoginseng Saponins (PNS), extracted from Panax Notoginseng as a traditional Asian medicine, displayed a significant anti-fibrosis effect in liver and lung. However, whether Ginsenoside Rg1 (Rg1), an important and active ingredient of PNS, exerts anti-fibrotic activity on IPF still remain unclear. In this study, we investigated the effect of Rg1 on bleomycin-induced pulmonary fibrosis in rats. Bleomycin (5 mg/kg body weight) was intratracheally administrated to male rats. Rg1 (18, 36 and 72 mg/kg) was orally administered on the next day after bleomycin. Lungs were harvested at day 7 and 28 for the further experiments. Histological analysis revealed that bleomycin successfully induced pulmonary fibrosis, and that Rg1 restored the histological alteration of bleomycin-induced pulmonary fibrosis (PF), significantly decreased lung coefficient, scores of alveolitis, scores of PF as well as contents of alpha smooth muscle actin (α-SMA) and hydroxyproline (Hyp) in a dose-dependent manner in PF rats. Moreover, Rg1 increased the expression levels of Caveolin-1 (Cav-1) mRNA and protein, lowered the expression of transforming growth factor-β1 (TGF-β1) mRNA and protein in the lung tissues of PF rats. These data suggest that Rg1 exhibits protective effect against bleomycin-induced PF in rats, which is potentially associated with the down-regulation of TGF-β1 and upregulation of Cav-1.

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Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway

Cited by 78 publications

References 62 publications

Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry

Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry

Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

Protective Effect of Ginsenoside Rg1 on Bleomycin-Induced Pulmonary Fibrosis in Rats: Involvement of Caveolin-1 and TGF-β1 Signal Pathway

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