Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure produces good long term control of intraocular pressure without risk of sight threatening complications

Prolonged Antiscarring Effects of Ilomastat and MMC after Experimental Glaucoma Filtration Surgery

“…Excessive subconjunctival scar contracture, which can lead to inadequate intraocular pressure control is the principal cause of failed surgical failure. 1,2 After surgical trauma, a tightly controlled sequence of cellular events occurs. The Tenon's fibroblast is the effector cell responsible for most aspects of healing.…”

Dietary Tocopherol Supplementation after Trabeculectomy and Phacotrabeculectomy: Double-Blind Randomized Placebo-Controlled Trial

“…Fuller et al [13 ]showed that the combination of systemic antifibrotic drugs (prednisolone, colchicine and flufenamic acid or diclofenac) was able to prevent fibrosis and bleb failure without significant local or systemic side effects in patients with signs of threatened early bleb failure.…”

Surgical Treatment of Canine Glaucoma

“…Topical corticosteroids, administered every 6 to 8 hours, not only aid in addressing the anterior uveitis postintracameral penetration, 1 but may help in suppressing the cyclooxygenase pathway and inhibiting fibroblasts proliferation, both responsible for implant fibrosis. 14,28,29 Several studies support the use of systemic corticosteroids to limit capsular fibrosis and achieve better IOP control in the human field [30][31][32] ; however, a report of the American Academy of Ophthalmology has recently disproved the claim. 33 Despite this current debate, systemic corticosteroids are currently recommended, when possible, in veterinary ophthalmology.…”