Anti-inflammatory Effects Of Statins In Sinusitis

Ayala, Estela; Le, Wei; Tsao, Gabriel; Hwang, Peter H.; Upadhyay, Daya

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4219

Cited by 2 publications

(7 citation statements)

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“…Our findings show an association between statin use and decreased prevalence of CRS in a nationally representative sample of outpatient visits in the United States. These findings support growing evidence that statins possess potent anti‐inflammatory properties in addition to their more well‐known role in treating cardiovascular disease through lipid reduction . Extensive laboratory and clinical studies support the idea of the anti‐inflammatory nature of statin medications.…”

Section: Discussionsupporting

confidence: 75%

“…These findings support growing evidence that statins possess potent anti-inflammatory properties in addition to their more well-known role in treating cardiovascular disease through lipid reduction. [12][13][14][15][16] Extensive laboratory and clinical studies support the idea of the anti-inflammatory nature of statin medications. Statins have been shown to reduce C-reactive protein (CRP) and proinflammatory cytokine levels in several different clinical trials.…”

Section: Discussionmentioning

confidence: 98%

“…The statin class of medications, also known as 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors, have long been used as agents in the treatment of hyperlipidemia and hypertriglyceridemia . However, research suggests that statins may also have anti‐inflammatory effects via modulation of lipid‐containing enzymes and mediators, and therefore may have clinical utility in the treatment of CRS . Although it has long been established that statins have antiproliferative actions against lymphocytes and other cell types, newer research has shown that statins also modulate the activity of both T cells and antigen presenting cells .…”

Section: Introductionmentioning

confidence: 99%

“…11,12 However, research suggests that statins may also have anti-inflammatory effects via modulation of lipid-containing enzymes and mediators, and therefore may have clinical utility in the treatment of CRS. [12][13][14][15][16] Although it has long been established that statins have antiproliferative actions against lymphocytes and other cell types, newer research has shown that statins also modulate the activity of both T cells and antigen presenting cells. 14 An in vitro study in which macrophages and various antigen presenting cells were treated with lovastatin showed that statins prevented the expression of tumor necrosis factor (TNF)-α and interleukin-1β, two molecules crucial in the body's inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

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Statin use protective for chronic rhinosinusitis in a nationally representative sample of the United States

et al. 2019

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Objectives/Hypothesis Statins have long been used in the management of cardiovascular disease for their lipid‐lowering properties. However, recent research suggests that statins may also have anti‐inflammatory effects via modulation of lipid‐containing enzymes and mediators, and therefore may have therapeutic value in the treatment of chronic rhinosinusitis (CRS). Study Design Retrospective database review. Methods The 2006 to 2015 National Ambulatory Medical Care Survey (NAMCS) data were queried to analyze the relationship between statin use and rates of CRS. CRS was indicated by the presence of an International Classification of Diseases, Ninth Revision code for CRS in one of the five diagnosis variables. Statin use was indicated by the presence of a statin medication in any of the 30 medication variables using the Multum Lexicon Drug Database, with newly prescribed medications excluded. Relevant demographic, socioeconomic, and comorbid factors were included in a multivariate logistic regression model, which accounted for the complex, stratified, multistage survey design of the NAMCS. Results There were 390,538 unweighted visit records used in the weighted analysis dataset, corresponding to 9,612,613,668 weighted visits. Statin use was associated with a decreased rate of CRS in both a univariate analysis (odds ratio [OR] = 0.53, P < .001) and the multivariate logistic regression accounting for comorbid, socioeconomic, and demographic factors (OR = 0.79, P = .030). Conclusions Statin use is associated with decreased rates of CRS based on a nationally representative sample of outpatient visits in the United States. This supports research that suggests statin medications may have protective properties against CRS, and further research is warranted into their potential therapeutic value for this indication. Level of Evidence NA Laryngoscope, 130:848–851, 2020

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Statin use protective for chronic rhinosinusitis in a nationally representative sample of the United States

et al. 2019

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“…[20][21][22][23] The immunomodulatory effects of statins have been reported in inflammatory disorders such as rheumatoid arthritis and vasculitis. [15][16][17][18][19][20][21][22][23] Although chronic sinusitis is a common presenting symptom of inflammatory airway diseases in millions of patients worldwide, the anti-inflammatory effects of statins in upper airway inflammation in sinusitis have never been studied before. [1][2][3][4][5][6][7][8][9]24 Moreover, there are no reports of antiinflammatory effects of statins in air pollution-induced upper airway inflammation, although air pollution acts as a frequent trigger that induces inflammation in human airways.…”

mentioning

confidence: 99%