Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules

Kim, Eun Hye; Shim, Bum-Sang; Kang, Shin-Wook; Jeong, Gajin; Lee, Jong-Soo; Yu, Young-Beob; Chun, Mison

doi:10.1016/j.jep.2009.08.027

Cited by 111 publications

(75 citation statements)

References 54 publications

(54 reference statements)

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“…Recently, catechins have been shown to inhibit the MAPK pathway and NF-κB activity (Kim et al, 2009;Guiterrez-Orozco et al, 2010). Consistent with these reports, our findings suggest that the inhibition of MAPK activation and NF-κB activity might be a good therapeutic strategy for TNBS-induced ulcerative colitis and propose that the inhibitory effect of catechins from Abarema cochliacarpos on inflammatory mediator expression could be mediated, at least in part, by blocking the MAPK pathway with subsequent inhibition of NF-κB activity.…”

Section: Discussionsupporting

confidence: 90%

Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats

Silva¹,

Sánchez-Fidalgo²,

Talero³

et al. 2011

Rev. bras. farmacogn.

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Inflammatory bowel diseases are characterized by a chronic clinical course of relapse and remission associated with self-destructive inflammation of the gastrointestinal tract. Active extracts from plants have emerged as natural potential candidates for its treatment. Abarema cochliacarpos (Gomes) Barneby & Grimes, Fabaceae (Barbatimão), is a native medicinal plant in to Brazil. Previously we have demonstrated in an acute colitis model a marked protective effect of a butanolic extract, so we decided to assess its anti-inflammatory effect in a chronic ulcerative colitis model induced by trinitrobenzensulfonic acid (TNBS). Abarema cochliacarpos (150 mg/day, v.o.) was administered for fourteen consecutive days. This treatment decreased significantly macroscopic damage as compared with TNBS. Histological analysis showed that the extract improved the microscopic structure. Myeloperoxidase activity (MPO) was significantly decreased. Study of cytokines showed that TNF-α was diminished and IL-10 level was increased after Abarema cochliacarpos treatment. In order to elucidate inflammatory mechanisms, expression of cyclooxygenase (COX)-2 and nitric oxide synthase (iNOS) were studied showing a significant downregulation. In addition, there was reduction in the JNK and p-38 activation. Finally, IκB degradation was blocked by Abarema cochliacarpos treatment being consistent with an up-regulation of the NF-kappaBbinding activity. These results reinforce the anti-inflammatory effects described previously suggesting that Abarema cochliacarpos could provide a source for the search for new anti-inflammatory compounds useful in ulcerative colitis treatment.

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Section: Discussionsupporting

confidence: 90%

Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats

Silva¹,

Sánchez-Fidalgo²,

Talero³

et al. 2011

Rev. bras. farmacogn.

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“…Scutellariae and its three major components (baicalin, baicalein and wogonin) have shown anti-inflammatory effects (Lin and Shieh 1996), while baicalin and baicalein exhibit anti-tumour activity (Ikemoto et al 2000;Kim et al 2009). As a component of White atractylodes, atractylenolide I can antagonise Toll-like receptor 4 (TLR 4 ) and inhibit inflammatory reactions (Li and He 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model

Geng¹,

Yuan²,

Wang³

et al. 2014

Vet. Med. - Czech

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Chinese herbal medicine has been used as an anti-abortive treatment in farm animals for thousands of years. To investigate the anti-abortive functions and mechanisms of Bai zhu san (BZS) on mifepristone (RU-486)-induced abortion, pregnant mice were allocated to different groups as follows: control group receiving neither RU-486 nor BZS; mice receiving RU-486 only; mice treated with both RU-486 and BZS. The results showed that the concentrations of IL-10 and IL-4 in uterine lysates were significantly higher in mice of the BZS + RU-486 group compared with the mice of the RU-486 group. The IL-10 and IL-4 levels in serum were several folds higher than that in uterus lysates. The IFN-γ concentrations in uterine lysate decreased significantly in mice of the BZS + RU-486 group vs. the RU-486 group. There were no significant differences in IL-2 concentrations between the mice of BZS + RU-486 or RU-486 groups and controls in the uterus and serum. The numbers of CD4 + , CD8 + T lymphocytes or macrophages in the uterus decreased in the BZS + RU-486 group compared with the RU-486 group. These results indicate that the Chinese herbal formula Bai zhu san inhibits RU-486-induced abortion and modulates the Th1/Th2 cytokine balance at the maternal-foetal interface.

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“…Scutellariae baicalensis, a medicinal plant, grows in various regions of Asia, including Siberia, the far east of Russia, Mongolia, China, Japan, and Korea, where it has been used as an ingredient in botanical formulations for thousands of years with positive results for the treatment of inflammatory diseases, allergies, hyperlipemia, diabetes, arteriosclerosis, and bacterial and viral infections [5,17,23,25,51,52,53,57]. This herb has been included as an important ingredient in various combination therapies such as Ger-Gen-Chyn-Tang [15], Soshiho-tang [28], and Shuanghuanglian [61].…”

Section: Introductionmentioning

confidence: 99%

Hot Water Extract of Scutellaria baicalensis Inhibits Migration, Invasion and Tube Formation in a Human Umbilical Vein Endothelial Cell Model and a Rat Aortic Ring Sprouting Model

Kim¹,

Bae²,

Kim³

et al. 2016

Journal of Life Science

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Angiogenesis is essential for the pathophysiological processes of embryogenesis, tissue growth, diabetic retinopathy, psoriasis, wound healing, rheumatoid arthritis, cardiovascular diseases, and tumor growth. Inhibition of angiogenesis represents an attractive therapeutic approach for the treatment of angiogenic diseases such as cancer. However, uncontrolled angiogenesis is also necessary for tumor development and metastasis. Inhibition of vascular endothelial growth factor (VEGF) signaling, a critical factor in the induction of angiogenesis, cause robust and rapid changes in blood vessels of tumors and therefore VEGF constitutes a target for such anti-angiogenic therapy. Recently, since natural compounds pose significantly less risk of deleterious side effects than synthetic compounds, a great many natural resources have been assessed for useful substance for anti-angiogenic treatment. Here we evaluated the anti-angiogenic effects of a hot water extract of Scutellaria baicalensis (SBHWE) using in vitro assays and ex vivo animal experiments. Our results show that SBHWE dose-dependently abrogated vascular endothelial responses by inhibiting VEGF-stimulated migration and invasion as well as tube formation in a human umbilical vein endothelial cell (HUVEC) model, without cytotoxicity, as determined by a cell viability assay. Further study revealed that SBHWE prevented VEGF-induced neovascularization in a rat aortic ring sprouting model. Taken together, our findings reveal an anti-angiogenic activity of Scutellaria baicalensis and suggest that SBHWE is a novel candidate inhibitor of VEGF-induced angiogenesis.

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Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules

Cited by 111 publications

References 54 publications

Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats

Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats

Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model

Hot Water Extract of Scutellaria baicalensis Inhibits Migration, Invasion and Tube Formation in a Human Umbilical Vein Endothelial Cell Model and a Rat Aortic Ring Sprouting Model

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