Anti-Inflammatory Effects of Salbutamol on Human Bronchial Epithelial Cells Stimulated by Cigarette Smoke Extract
Gustavo Cintra Gouveia,
Henrique Ismarsi de Sousa,
Aline Beatriz Mahler Pereira
et al.
Abstract:Cigarette smoking, the major cause of chronic obstructive pulmonary disease (COPD), induces activation of pro-inflammatory pathways in the airway epithelium. Salbutamol, a selective and short-acting ?2-adrenoceptor agonist, is used for bronchospasm relief in patients with asthma and COPD. In addition, salbutamol also presents anti-inflammatory effects. Here, we evaluated whether salbutamol (10-5-10- 7 M) can reduce on bronchial epithelial cells (BEAS-2B cells) the inflammatory parameters induced by cigarette s… Show more
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