2015
DOI: 10.1590/s1677-5538.ibju.2014.0470
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Anti-inflammatory effects of royal jelly on ethylene glycol induced renal inflammation in rats

Abstract: Objective:In this study, anti-inflammatory effects of Royal Jelly were investigated by inducing renal inflammation in rats with the use of ethylene glycol. For this purpose, the calcium oxalate urolithiasis model was obtained by feeding rats with ethylene glycol in drinking water.Materials and Methods:The rats were divided in five study groups. The 1st group was determined as the control group. The rats in the 2nd group received ethylene glycol (1%) in drinking water. The rats in the 3rd group were daily fed w… Show more

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Cited by 53 publications
(44 citation statements)
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“…Group 1 was used as the control group. The rats in the experimental groups (groups 2, 3, 4, 5, and 6) were given free access to drinking water containing 1.0% ethylene glycol as a stone inducer throughout the entire 4-week experimental period [20]. The rats in group 2 were treated as the urolithic group; the rats in group 3 were treated with potassium citrate at 2.0 g/kg/day for 28 days; the rats in group 4 were fed daily with Glechoma longituba at a dose of 220 mg/kg/day using oral gavage; and the rats in group 5 were fed daily with Glechoma longituba at a dose of 440 mg/kg/day using oral gavage; the rats in group 6 were fed daily with Glechoma longituba at a dose of 880 mg/kg/day using oral gavage.…”
Section: Methodsmentioning
confidence: 99%
“…Group 1 was used as the control group. The rats in the experimental groups (groups 2, 3, 4, 5, and 6) were given free access to drinking water containing 1.0% ethylene glycol as a stone inducer throughout the entire 4-week experimental period [20]. The rats in group 2 were treated as the urolithic group; the rats in group 3 were treated with potassium citrate at 2.0 g/kg/day for 28 days; the rats in group 4 were fed daily with Glechoma longituba at a dose of 220 mg/kg/day using oral gavage; and the rats in group 5 were fed daily with Glechoma longituba at a dose of 440 mg/kg/day using oral gavage; the rats in group 6 were fed daily with Glechoma longituba at a dose of 880 mg/kg/day using oral gavage.…”
Section: Methodsmentioning
confidence: 99%
“…The anti-inflammatory response of RJ could induce renal inflammation in the rats with the use of ethylene glycol. The presence of pro-inflammatory/anti-inflammatory cytokines, such as TNF-α, IL-1β, and IL-18 levels in the blood and renal tissue of rats, reflect that anti-inflammatory response of RJ due to its anti-radicals and anti-oxidative effects [94]. The dietary RJ administration improves metabolic effect and skeletal muscle functions in aged obese rats.…”
Section: Anti-inflammatory Effectmentioning
confidence: 99%
“…It is a natural antibiotic and plays an efficient role in developing the larval stages in blood cells and maintains its ovulatory characteristics during the whole life span. Moreover, RJ has antioxidants with the potential of reducing the risk of cancer, high blood pressure, diabetes, and cardiovascular diseases [94,110,111]. RJ also affects the morphological characters, growth, learning, size, and shape variations in various creatures, such as honeybees, mice, and humans [112].…”
Section: Biological Activity Of Rjmentioning
confidence: 99%
“…Proper nutrition, in addition to its effect on physical function, has a tremendous impact on mental and brain function as well as memory; thus nutritional deficiencies can cause or aggravate mental and emotional illnesses. activities in different cell types and tissues of animal models (8)(9)(10)(11). The RJ is mainly made up of proteins, sugars, fats (including sterols and fatty acids) and trace amounts of mineral salts and vitamins (8).…”
Section: Introductionmentioning
confidence: 99%