Anti-inflammatory effects of propofol are mediated by apolipoprotein M in a hepatocyte nuclear factor-1α-dependent manner

Ma, Xin; Hu, Yan‐Wei; Zhao, Zhenlong; Qiu, Yurong; Huang, Jinlan; Wu, Xiaojuan; Yang, Jia; Zhao, Jiayi; Li, Shufen; Gu, Min; Wang, Qian

doi:10.1016/j.abb.2013.03.002

Cited by 36 publications

(38 citation statements)

References 27 publications

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“…Looking at the time scale of their experiments (maximal effect at 24 hours) one could argue that a similar direct effect of propofol (and Intralipid ® ) on apolipoprotein A-I expression was involved in our study. So, the initial higher proinflammatory reaction in the propofol and Intralipid ® groups (potentially due to dampened cortisol response as outlined above, as well as a number of confounding factors present in our study such as higher number of bilateral interventions, longer surgery duration and higher nicotine consumption present in the two lipid groups) seems to have been followed by a subsequent antiinflammatory effect of propofol and Intralipid ® with up-regulation of Apo A-I expression and decreasing IL-6 levels (i.e., similar to the effects of propofol as observed in the study by Ma et al with up-regulation of Apo M expression) [14]. Obviously, these first clinical observations can only be regarded as preliminary (pilot study) and more studies are needed, both for confirmation as well as to clarify any associated clinical significance [39].…”

Section: Propofolsupporting

confidence: 70%

“…They observed that propofol was able to up-regulate the apolipoprotein M (Apo M) expression in hepatocytes and macrophages [14]. Looking at the time scale of their experiments (maximal effect at 24 hours) one could argue that a similar direct effect of propofol (and Intralipid ® ) on apolipoprotein A-I expression was involved in our study.…”

Section: Propofolmentioning

confidence: 88%

“…In their recent animal studies Ma and coworkers found antiinflammatory effects of propofol [14]. They observed that propofol was able to up-regulate the apolipoprotein M (Apo M) expression in hepatocytes and macrophages [14].…”

Section: Propofolmentioning

confidence: 99%

“…Its pharmacokinetic characteristics made it a widely used anesthetic agent for surgical procedures and for sedation in intensive care units [4,5]. Although some authors demonstrated that propofol could trigger a proinflammatory immune response [6][7][8], other clinical and laboratory studies showed that propofol would exert a suppressive effect on the immune system [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Propofol and perioperative inflammation-the Intralipid® solvent may play a role

Bandschapp¹,

Chenaud²,

Inan³

et al. 2015

Glob Anesth Perioper Med

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The inflammatory properties of propofol are still debated. Apolipoprotein A-I is involved in the inflammation. We sought to determine how propofol or its solvent Intralipid® modulate Apolipoprotein A-I and the inflammatory response after surgical stress. Patients undergoing laparoscopic inguinal hernia repair were allocated to anesthesia with propofol (n=25), isoflurane alone (n=27) or in combination with Intralipid® (n=27). Apolipoprotein A-I and inflammation were assessed before, during and after surgery. Following a decrease in all groups, Apolipoprotein A-I levels tended to recover significantly earlier when propofol or Intralipid® were given (p<0.05). Cortisol increased in the control group whereas it remained at baseline levels when lipids were given. In this study the administration of lipids, i.e. propofol or its solvent Intralipid®, in the perioperative setting was associated with a more pronounced yet rapidly recovering acute phase reaction.

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Section: Propofolsupporting

confidence: 70%

Section: Propofolmentioning

confidence: 88%

Section: Propofolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Propofol and perioperative inflammation-the Intralipid® solvent may play a role

Bandschapp¹,

Chenaud²,

Inan³

et al. 2015

Glob Anesth Perioper Med

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“…For instance, propofol inhibited inflammatory responses in lipopolysaccharide (LPS)-induced alveolar epithelial type II cells [18]. And it attenuated secretion of proinflammatory cytokines in a hepatocyte nuclear factor-1α-dependent manner [19]. Emerg ing reports suggested that propofol effectively down-regulated inflammatory responses by inhibiting the phosphorylation of nuclear factor-κB (NF-κB) and p38 mitogen-activated protein kinase (MAPK) [25,26,33].…”

Section: Introductionmentioning

confidence: 99%

Propofol attenuates intermittent hypoxia induced up-regulation of proinflammatory cytokines in microglia through inhibiting the activation of NF-Bκ/p38 MAPK signalling

Liu¹,

Sun²,

Lian³

et al. 2017

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A b s t r a c t As immune sentinels of the central nervous system (CNS), microglia is pivotal cellular mediator of neuroinflammatory processes. Activation of microglia might elicit the expression of proinflammatory cytokines involved in the progression of neuroinflammatory diseases. Numerous studies have demonstrated that propofol (2,6-diisopropylphenol) has an effective anti-inflammatory property. Intermittent hypoxia (IH), as a result of obstructive sleep apnoea (OSA), could lead to neuron damage and neuroinflammation in the CNS. Here, we determined the effects of propofol on the inflammatory response in microglia during IH. The levels of nuclear factor-κB (NF-κB) inhibitor (IκB) and activated p38 mitogen-activated protein kinase (MAPK) exposed to IH with or without propofol treatment were detected by Western blot. The viability of cells exposed to various concentrations of propofol was monitored with MTT assay. The production and mRNA levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were evaluated by qRT-PCR

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The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: A double‐blind randomized controlled trial

Wong

Leung

Cheung

2019

European Journal of Pain

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Background Total intravenous anaesthesia (TIVA) with propofol may reduce pain after surgery compared with inhalational anaesthetic techniques. Whether propofol provides analgesic benefit may be influenced by the surgical procedure and anaesthetic/analgesic regime. Third molar surgery is a consistent and fairly standard surgical technique that provides a good model for postoperative pain. We investigated whether propofol TIVA or sevoflurane (SEVO) inhalational anaesthesia would produce better quality pain relief after third molar surgery. Methods In this double‐blind, randomized controlled trial, patients scheduled for bilateral third molar surgery received propofol TIVA or SEVO inhalational anaesthesia. Postoperative numerical rating pain scores, analgesic consumption, adverse effects and global pain satisfaction were assessed. Results Data from 48 patients in each group were analysed. The area under curves for numerical rating scale pain scores were significantly lower in the propofol TIVA group at rest and during mouth opening between 1 and 72 hr after surgery (p = 0.013 at rest, p = 0.021 with mouth opening). There was no difference in postoperative analgesic consumption. Propofol TIVA was associated with less postoperative headache (p = 0.041 in the postoperative anaesthetic care unit, p = 0.036 in ward). There were no differences in other adverse effects including postoperative nausea and vomiting. Global pain satisfaction and level of postoperative discomfort at 24 hr after surgery were significantly better in the propofol TIVA group (p = 0.008 and p = 0.009, respectively). Conclusion Propofol TIVA was associated with reduced postoperative pain after bilateral third molar surgery, but did not reduce postoperative analgesic consumption. Significance Choice of general anaesthetic technique can affect postoperative analgesia. The results of this study suggest that propofol TIVA improves postoperative pain and patient satisfaction after third molar surgery compared to inhalational anaesthesia.

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Anti-inflammatory effects of propofol are mediated by apolipoprotein M in a hepatocyte nuclear factor-1α-dependent manner

Cited by 36 publications

References 27 publications

Propofol and perioperative inflammation-the Intralipid® solvent may play a role

Propofol and perioperative inflammation-the Intralipid® solvent may play a role

Propofol attenuates intermittent hypoxia induced up-regulation of proinflammatory cytokines in microglia through inhibiting the activation of NF-Bκ/p38 MAPK signalling

The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: A double‐blind randomized controlled trial

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